慢性丙型肝炎患者HLA-DRB等位基因表达频率分析及其与抗病毒治疗应答关系的比较

To study the association between HLA-DRB and chronic hepatitis C infection and its effect on the response to interferon alpha and ribavilin therapy. Gene chips were used to analyze the frequency of HLA-DRB in 25 patients with chronic hepatitis C infection and 30 healthy individual, the response to interferon alpha and ribavilin therapy of the 25 patients were discussed to study the association between HLA-DRB and chronic hepatitis C infection and its effect on the therapy. The frequency of HLA-DRB104 and DRB113 allele in patients with chronic hepatitis C infection were higher than those in normal control (P<0.05) . The response rate to IFN and ribavilin therapy in patients with DRB107 are higher than those with DRB104. Sex, HCV type and HLA-DRB were all related to the response. DRB107 allele and HCV type Ⅳ were the closest factors related to the response in these elements. Not only virus but also host play an important role on the curative effect in anti-virus therapy.