中文|English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2006
Turn off MathJax
Article Contents

肝硬化患者肠通透性及乳果糖对其影响的研究

  • Published Date: 2006-02-20
  • To study the characteristic of intestinal permeability in patients with liver cirrhosis and the efficacy of lactulose on intestinal permeability and endotoxemia.The study was divided into two parts.First one is to study intestinal permeability in cirrhosic patients.patients with cirrhosis and healthy control subjects was involed in it.Serum diamine oxidase (DAO) , serum endotoxin was determined in patients with cirrhosis, Only diamine oxidase (DAO) was determined in the normal controlls.The second part is effects of lactulose on intestinal permeability and endotoxemia.Patients was divided into two groups randomly.Lactulose was given orally and cirrohsis was treated in lactulose group.Lactulose was not given in non lactulose one.Serum diamine oxidase (DAO) , serum endotoxin was determined again after two weeks.Endotoxemia occurred in majority of patients with cirrhosis (73.8%) , Serum DAO is higher in patients than in control subjects.Serum endotoxin is liner correlative with serum DAO.Serum endotoxin and serum DAO are higher in patients with ascites than patients without.Both Serum DAO and endotoxin are lower after lactulose treatment than before.

     

  • loading
  • [1]F ink MP.Gastrointestinal muosal in jury in experim ental model ofshock, trauma and sepsis[J].C rit Care M ed, 1991, 19 (5) ∶627-640.
    [2]Lunn PG, Northrop, C lewes CA, et al.Intestinal perm eab ility, mu-cosal in jury, and growth faltering in Gamb ian infants[J].Lancet, 1993, 338 (8772) ∶907-910.
    [3] Luk GD, Bayless TM, Baylin SB.D iam ine oxidese (H istammase) .A circu latingmarker for rat intestinalmucosalmaturation and integri-ty[J].J clin ical investingation, 1980, 66 (1) ∶66-70.
    [4]Luk GD, Bayless TM, Baylin SB.P lasma postheparin d iam ine ox-idese sensitive provocative test for quantitating length of acute intesti-nalmucosal in jury in the rat[J].Journal of clin ical investingation, 1983, 71 (5) ∶1305-1308.
    [5]陈秀凯, 邱方, 程爱国.肠道屏障功能的监测方法的现状与进展[J].中国煤炭工业医学杂志, 2003, 6 (7) ∶669-671.
    [6]L in RS, Lee FY, Lee SD, et al.Endotoxem ia in patientsw ith chron-ic liver d isease∶Ralationsh ip to severity of liver d iseases, presence ofesophageal varices, and hyperdynam ic circu lation[J].J Hepatol, 1995, 22 (2) ∶165-72.
    [7]王锦辉, 陈氵湖, 孙光裕, 等.肝硬化患者小肠细菌过度生长与内毒素血症[J].中华内科杂志, 2002, 41 (7) ∶459-461.
    [8]张顺才, 王唯, 任卫英, 等.西沙必利对肝硬化大鼠小肠细菌及内毒素转位的影响[J].中华肝脏病杂志, 2003, 11 (9) ∶539-541.
    [9]Madrid AM, Hurtado C, Venegas M, et al.Long-term treatm entw ith cispride and antib iotics in liver cirrhosis∶effect on small intes-tinal motility, bacterial overgrwth, and liver function[J].Am J Gas-troenterol, 2001, 96 (4) ∶1251-1255.
    [10]刘仁宽, 温朗聪, 王崇霞.乳果糖研究进展[J].中国微生态学杂志, 1997, 9 (3) ∶62-64.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2673) PDF downloads(821) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return