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Jan.  2007
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Article Navigation >  Journal of Clinical Hepatology  > 2007  >  23(1): 19-21

血清透明质酸Ⅲ型前胶原Ⅳ型胶原及脯氨酸肽酶对肝组织纤维化诊断的意义

  • Published Date: 2007-01-20
    Abstract
  • To determine the relationship between hyaluronic acid (HA) , typeⅢ procollagen (PCⅢ) , type-Ⅳ collagen (CⅣ) or proline dipeptidase (PLD) and degree of liver fibrosis.HA, PCⅢ, CⅣ and PLD in the serum from 225 pa-tients with all type of liver disease were measured by ELISA and biochemistry colorimetry and analyzed their relationshipwith the pathological inflammation-grade and fibrosis-stage of liver biopsy tissues.There were significant correlation (P<0.05) between the four indexes and the degree of inflammation, necrosis and fibrosis.The serological indexes are in ac-cordance with the pathological degree of live tissues.It could reflect both the severe degree of hepatofibrosis and the statusof hepatocellular necrosis by co-measuring HA、PCⅢ or CⅣ and PLD in the serum, that provides reference for clinicaldiagnosis and treatment.

     

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    • References(7)
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    [2]中华医学会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19∶56-62.
    [3]许爱民, 纪民, 耿平梅.血清肝纤维化标志物水平与肝组织炎症活动度纤维化程度的相关性分析[J].临床肝胆病杂志, 2005, 21 (3) ∶175-176.
    [4]Varmanen P, Steeie J, Paiva A.Characterization of a prolnase geneand its product and adjacent ABC transporter gene from lactobacillus[J].Microbiology, 1996, 142 (4) ∶809-816.
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    [6]王泰玲, 王宝恩, 刘霞, 等.慢性病毒性肝炎肝纤维化分期与血清学指标的关系[J].中华病理学杂志, 1998, 27∶185-190.
    [7]Pilette C, Rousseiet Mc, Bedossa P, et al.Histopithological ealu-ation of liver fibrosis:Quantitative inlage analeysisrs semi-Quantitative scores[J].HPAtol, 1998, 8∶439-446.
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