慢性乙型肝炎患者外周血单核细胞膜干扰素α/β受体的表达

To study the relationship between the antiviral efficiency of interferon (IFN) α and the level of IFN α/β receptor expressed on the membranes of peripheral monocytes in patients with chronic hepatitis B (CHB) .Thirty CHB patients received IFN-α for six months.The expression levels of IFN α/β receptor in peripheral monocytes from 30 CHB patients were examined with flow cytometry.The expression level of responders and nonresponders were compared.And there was significant distinction on the expression level of IFN α/β receptor between the two groups (P<0.05) .Logistic regression analysis showed that receptors on the surface of monocytes were capable to be treated as independent predictors of the efficacy of IFN therapy.The pretreatment receptor on the surface of monocytes was capable to be treated as independent predictor on the efficacy of IFN therapy for CHB patients.