慢性乙肝YMDD变异患者肝纤维化指标、血清标志物的检测及意义

To Study variation and clinical significance of the hepatic fibrotic indexes and serous markers form patients with chronic hepatitis B (CHB) and variation of HBV DNA YMDD.The 285 patients with the diagnose of CHB were detected for YMDD mutation.According to the results, the cases were divided into mutation group and nonmutation group.Moreover, they were further separated into therapy group treated with lamivudine and control group.HBV-DNA, HBV M, ALT, AST, GGT, HA, PCⅢ and CⅣ were studied.The HBV DNA YMDD sequence of 144 cases mutated compared with the control group.The HBeAg positive rate and the level of HBV DNA of mutation group were higher than those of nonmutation group (P<0.01, P<0.05) .While the PⅣ、PCⅢ、HBV DNA of therapy group from the YMDD nonmutation cases decreased evidently.The HBeAg positive rate and HBV DNA were probably related to the YMDD mutation.The use of lamivudine might ameliorate fibrosis of the hepatic tissue form nonmutation cases.