IL-10基因多态性与乙肝肝硬化易感性的相关性研究

To study the possible association of the genetic polymorphism of interleukin (IL) -10 with the susceptibility to HBV-induced liver cirrhosis.Peripheral blood samples were collected from 100 patients with HBV-induced liver cirrhosis and 124 healthy controls.The polymorphisms at position-1082G/A, -592A/C of the promoter of IL-10 gene were determined by polymerase chain reaction-restriction fragment length polymorphisms analysis (PCR-RFLP) .For position-592A/C, the genotype frequency and allele frequencies were not significantly different between the cirrhosis group and healthy group (P>0.1) .For position-1081G/A, relative higher AA genotype frequency and an A allele frequency were found in cirrhosis group (P<0.05) .And the rate to get liver cirrhosis was 0.373 among people with G allele compared with A allele (95%confidence interval was 0.116-0.838) .The results suggested that the genotype of IL-10-1082G/A positiion was associated with the susceptibility to HBV-induced liver cirrhosis.