中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2007

肝肾综合征患者血清肿瘤坏死因子-α的测定及其意义

  • Published Date: 2007-06-20
  • Objective To investigate the role of tumor necrosis factor-α (TNF-α) in the pathogenesis of hepatorenal syndrome (HRS) .Methods The concentration of TNF-α and renal function were quantitatively assessed in 90 patients with liver cirrhosis and 26 healthy patients.The relativity of TNF-α to creatinine clearance rate (Ccr) was analyzed.Results In cirrhotic group with renal dysfunction, the serum TNF-α levels were significantly higher than those in normal control group and cirrhotic group without renal dysfunction, and increased with the aggravated degree of renal dysfunction, TNFα concentrations inversely correlated with the Ccr.Conclusion TNF-α may play an important role in the development of HRS.

     

  • [1]Schrier RW, Arroyo V, Bernardi M, et al.Peripheral arterial vaso-dilation hypothesis:a proposal for the initiation of renal sodium andwater retention in cirrhosis[J].Hepatology, 1988, 8 (5) ∶1151-7.
    [2]Gentilini P, Laffi G, Buzzelli G, et al.Functional renal alterationsin chronic liver dissases[J].Digestion, 1980, 20 (2) ∶73-78.
    [3]Laffi G.Villa G, Gentilini P.Pathogenesis and management of thehepatorenal syndrome[J].Semin Liver Dis, 1994, 14 (1) ∶71-81。
    [4]华嘉临, 占强, 郭继忠.血清肿瘤坏死因子-α与肝硬化的关系[J].江苏大学学报 (医学版) , 2002, 12 (6) ∶657-8.
    [5]Tily H, Willmer A, Vogel W.Serum levels of cytok ines in ch ronicliver disease[J].Gastroenterology, 1992, 103 (1) ∶264-74.
    [6]Mookerjee RP, Sen S, Davies NA, et al.Tumour necrosis factor al-pha is an important mediator of portal and systemic haemodynamicderangements in alcoholic hepatitis[J].Gut, 2003, 52 (8) ∶1182-7.
    [7]Piepot HA, Groeneveld AB, van Lambalgen AA, et al.Tumor nec-rosis factor-alpha impairs endothelium-dependent relaxation of ratrenal arteries, independent of tyrosine kinase[J].Shock, 2002, 17 (5) ∶394-8.
    [8]Donnahoo KK, Shames BD, Harken AH, et al.Review article:therole of tumor necrosis factor in renal ischemia-reperfusioninjury[J].J Urol, 1999, 162 (1) ∶196-203.
    [9]Stark ME, Bauer AJ, Sarr MG, et al.Nitric oxide mediates inhibito-ry nerve input in human and canine jejunum[J].Gastroenterology, 1993, 104 (2) ∶398-409.
    [10]Poole S, Bird TA, Selkirk S, et al.Fate of injected interleukin1 inrats:sequestration and degradation in the kidney[J].Cytokine, 1990, 2 (6) ∶416-22.
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