IRIS13 C-美沙西汀呼气试验在肝硬化患者中的应用及评价

Objective To investigate the clinical value of 13C-methacetin breath test in the assessment of liver function in patients with cirrhosis.Methods 42 patients with liver cirrhosis were divided into three groups, 16 patients in Child-pugh classification A, 21in B and 5 in C.All received liver functional test and 13C-methacetin breath test at the same time.Results According to the severity of Child-pugh classification, the parameters of breath test: MVmax40 (a ratio between the maximum velocity before 40 minutes and the standard (27) , CUM40 (a ratio between the cumulative percentage 13C dose recovered over 40 minutes and the standard (12) and CUM120 (a ratio between the cumulative percentage 13C dose recovered over 120 minutes and the standard (28) ) were obviously reduced.The difference of them among these groups was significant (P<0.05) .The three parameters were significantly correlated with Child-pugh classification score and other clinical standard liver function tests (P<0.05) .Conclusion 13C-methacetin breath test can react to the liver functions of compensation and reservation actually.It is a helpful supplement technique of Child-pugh classification and clinical standards liver function tests, it is a test of instant, safe, effective, quantitative and non-invasive.