Objective To investigate the change and clinical significance of serous chemokine CXCL16 in patients with hepatitis B.Methods The serous concentration of CXCL16 was detected by enzyme linked immunosorbent assay (ELISA) ;HBV-DNA was detected by fluorescent quantitive polymerase chain reaction (FQ-PCR) ;Liver function was assayed by automatic biochemistry analyzer.Results Concentration of serous CXCL16 in normal group (n=25) 、AHB (acute hepatitis B) group (n=24) and CHB (chronic hepatitis B) group (n=32) was 1.676±0.766 (ng/ml) 、2.150±0.714 (ng/ml) and 2.417±0.537 (ng/ml) respectively.The concentration of CXCL16 in AHB and CHB groups were both significantly higher than that of normal group, (P=0.015, 0.000, respectively) .However, the disparity of CXCL16 concentration between AHB and CHB group isn't statistically significant (P=0.142) .Likewise, no statistical significance of the difference of CXCL16 was found between HBeAg positive (n=26) and negative (n=30) patients group (P=0.741) .There is no correlation between the concentration of CXCL16 and the level of ALT (r=-0.46, P=0.7365) , so as the association of CXCL16 and HBVDNA (r=-0.191, P=0.158) .Nevertheless, the concentration of CXCL16 is raised as the pathogenetic condition aggravated.Conclusion It is possible that CXCL16 play a role in liver inflammatory in hepatitis B.The change of the serous concentration of CXCL16 isn't evidently related with that of ALT、HBVDNA and HBeAg.
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