慢性乙型肝炎患者血清铁、铁蛋白水平与脂质过氧化损伤的关系

Objective To investigate the relationship between serum iron (SI) , serum ferritin (SF) and lipid peroxidation injury in patients with chronic hepatitis B.Methods 79 patients with chronic hepatitis B were enrolled in this study.SI was detected by chromatometry, SF by Radio-immunity, MDA by thiobarbituric acid method, and SOD by xanthineoxidase method.Results Compared to control group, the level of SI, FE and MDA in patients with chronic hepatitis B were higher significantly (P<0.05-0.01) .On the contrary, the level of SOD in patients with chronic hepatitis B was lower significantly (P<0.01) .In 79 patients with chronic hepatitis B, correlation analyses found that SI and FE were in positive correlation with MDA (r=0.493, P<0.01, r=0.745, P<0.01) , and SI was in negative correlation with SOD (r=-0.27, P<0.05) .Conclusion The levels of SI and SF in patients with chronic hepatitis B are closely related to lipid peroxidation injury, and the overload of iron may enhance the hepatocytes damage induced by HBV.