胆结石患者胆汁中幽门螺杆菌细胞毒素相关蛋白的检测及意义

Objective To study the relationship between the Helicobacter pylori infection and the formation of gallstones.To explore the evidence of Hp existing and the detective methods of bacteria in biliary tract.Methods Twenty-eight cases of patients with gallstone collected bile by direct puncture during operation and other eight cases with gallstone by ERCP operation.Hp CagA immunoglobulin G detected by enzyme-linked immunosorbent assays (ELISA) .Sixteen cases of patients without gallstone was the control group.Results The detection of Hp-CagA IgG of the two groups has significant difference.There was also significant difference with/without acute cholangitis in biliary tract of the patients with gallstone.However, there was no significant difference between the direct puncture group and ERCP group.Conclusion Hp exists possibly in biliary tract and has some relationship with the formation of gallstone.It's feasible to detect Helicobacter pylori CagA IgG through ERCP.