中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2008
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胆囊良恶性病变组织中神经生长因子(NGF)及其mRNA表达的临床病理意义研究

  • Published Date: 2008-03-20
  • Objective To study the expressive levels and clinicopathological significances of NGF and NGF mRNA in the benign and malignant lesions of gallbladder.Methods EnVisionTM immunohistochemical method for detection of NGF and in situ hybridization for expressive levels of NGF mRNA was used in the routinely paraffinembedded sections from patients of gallbladder adenocarcinoma (n-108) , paraneoplastic tissues (n=45) and chronic cholecystitis (n=35) .Results The positive rates and scores of NGF and NGF mRNA in gallbladder adenocarcinoma were significantly higher than those in paraneoplastic tissues and chronic cholecystitis (P<0.01) .The positive rates and scores of NGF and NGF mRNA were significantly lower in the cases of adenomatous canceration or high-differentiated adencarcinoma, maximal diameter of mass≥2cm, metastasis of lymphnode, and invasion of regional tissues (P<0.05 or P<0.01) .Conclusion The expressive levels of NGF and/or NGF mRNA might be important biological markers for reflecting the carcinogenesis, progression, biological behaviors and prognosis of gallbladder adenocarcinoma.

     

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