肝癌组织M30蛋白表达及其与凋亡的关系

Objective To study the expression of M30 protein in primary hepatic carcinoma and the relationship between M30 expression and apoptosis in the tumor.Methods The expression of M30 protein was examined with immunohistochemical S-P method in 80 PHC tissues and pericarcinomatous hepatic tissues and 10 normal 1iver tissues.The apoptosis index (AI) was examined with terminal deoxymucleotidyl transference enzyme mediated dUTP nick end labeling (TUNEL) technique.Results M30 index was 9.10±7.05、3.31±3.02、0.10±0.32 respectively in PHC tissues, pericarcinomatous hepatic tissues and normal 1iver tissues.M30 index of PHC was closely associated with TNM stage, histological differentiation, growth patten, survival and recurrent time (P<0.05) .The expression of M30 was positively correlated with the AI of PHC cell (P<0.01) .Conclusion M30 is possible to be an indicator of PHC prognosis.