Objective To study the relationship between HLA-DRB1*14 and HLA-DRB1*15 genes and hepatocellular carcinoma.Methods 40 patients with hepatocellular carcinoma and 135 healthy controls were included in the study.HLA-DRB1 genes were detected by PCR-SSP.Results The frequency of HLA-DRB1*14 was significantly higher than the control group (χ2=9.925, P=0.002, OR=3.450, 95%CI:1.555～7.655) , however, no significant difference was found in HLA-DRB1*15 frequency between the two groups (χ2=1.260, P=0.262, OR=1.538, 95%CI:0.723～3.274) .Conclusion HLA-DRB1*14 might be the responsible gene for the development of hepatocellular carcinoma with a minor effect by HLA-DRB1*15 genes.
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