Effect of medical ozone therapy in the hepatorenal syndrome in patients with chronic severe hepatitis

Objective The study is aimed to observe the effects of medical ozone therapy on PRA, AngⅡ, ALD, renal blood flow and renal function in patients with severe chronic hepatitis and to explore the prevention of medical ozone therapy on hepatorenal syndrome.Methods 98 cases with chronic severe hepatitis were randomly divided into ozone therapy group (50 cases) and control group (48 cases) .The patients in the treatment group were treated with medical ozone plus the same basic medical treatments used for the control group.100 ml venous blood was drawn from each patient, and was mixed with 100 ml (35 μg/ml) medical ozone and then was returned the blood to the patient intravenously, once every other day for 20 days.Renal blood flow of the patients were determined by American GELOGIO-7 color Doppler ultrasonic examination.The levels of PRA, AngII and ALD were detected by RIA.Results The levels of PRA, AngⅡ, ALD in the treatment group were decreased significantly compared with those before treatment (P < 0.01) , also lower than those of control group after treatment (P < 0.01) .Renal blood flow was increased compared to before the treatment and also higher than that of the control group after the treatment (P < 0.01) .Renal damage (hepatorenal syndrome) happened in the treatment group was less than that in the control group (P < 0.01) .The survival rate in the treatment group was higher than that in the control group.Conclusion Combination therapy of medical ozone could decrease levels of PRA, AII and ALD significantly, increase renal blood flow, prevent hepatorenal syndrome and improve the survival rate of patients with chronic severe hepatitis.