中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2011
Turn off MathJax
Article Contents

Research in the progress of non-invasive diagnosis of liver fibrosis

  • Published Date: 2011-02-20
  • Liver fibrosis is a life-threatening disease evolving from different liver disease,is one of the most common cause of death.Fibrosis is characterized by excessive deposition of extracellular matrix in the tissue and tissue restatement as consequence of chronic liver damage.Liver biopsy is the most reliable indicator of the degree of hepatic fibrosis and inflammatory activity,but biopsy is an invasive examination.There are some risks and limitations,so it is necessary to look for an accurate and reliable non-invasive method to provide the basis for diagnosis and treatment of liver fibrosis.In recent years,advances in serology and imageology such as serum marker panels,FibroScan,et al can assess fibrosis accurately and reduce the need for a liver biopsy.But at present,all have failed to completely replace liver biopsy because of their respective limitations in current researches.The searching for an ideal surrogate is still in progress.

     

  • loading
  • [1]Manning DS,Afdhal NH.Diagnosis and quantitation offibrosis[J].Gastroenterology,2008,134(6):1670-1681.
    [2]Bedossa P,Dargere D,Paradis V.Sampling variability ofliver fibrosis in chronic hepatitis C[J].Hepatology,2003,38(6):1449-1457.
    [3]Gressner OA,Weiskirchen R,Gressner AM.Biomarkersof hepatic fibrosis,fibrogenesis and genetic pre-disposition pending between fiction and reality[J].J CellMol Med,2007,11(5):1031-1051.
    [4]Dufour DR.Assessment of liver fibrosis:can serumbecome the sample of choice?[J].Clin Chem,2005,51(10):1763-1764.
    [5]Tarcin O,Gedik N,Karakoyun B,et al.Serum prolidaseand IGF-1 as non-invasive markers of hepatic fibrosisduring four different periods after bile-ductligation inrats[J].Dig Dis Sci,2008,53(7):1938-1945.
    [6]Kurien BT,Patel NC,Porter AC,et al.Prolidase deficiencyand the biochemical assays used in its diagnosis[J].AnalBiochem,2006,349(2):165-175.
    [7]Kayadibi H,Gultepe M,Yasar B,et al.Diagnostic valueof serum prolidase enzyme activity to predict the liverhistological lesions in non-alcoholic fatty liver disease:Asurrogate marker to distinguish steatohepatitis fromsimple steatosis[J].Dig Dis Sci,2009,54(8):1764-1771.
    [8]Friedman SL.Molecular regulation of hepatic fibrosis,an integrated cellular response to tissue injury[J].J BiolChem,2000,275(4):2247-2250.
    [9]Zeremski M,Dimova R,Brown Q,et al.Peripheral CXCR3-associated chemokines as biomarkers of fibrosis inchronic hepatitis C virus Infection[J].J Infect Dis,2009,200(11):1774-1780.
    [10]Zeremski M,Petrovic LM,Chiriboga L,et al.Intrahepaticlevels of CXCR3-associated chemokines correlate withliver inflammation and fibrosis in chronic hepatitis C[J].Hepatology,2008,48(5):1440-1414.
    [11]Shaheen AA,Myers RP.Diagnostic accuracy of theaspartate aminotransferase-to-platelet ratio index for theprediction of hepatitis C-related fibrosis:a systematicreview[J].Hepatol,2007,46:912-921.
    [12]Poynard T,McHutchison J,Manns M,et al.Biochemicalsurrogate markers of liver fibrosis and activity in arandomized trial of peginterferon alfa-2b and ribavirin[J].Hepatology,2003,38(2):481-492.
    [13]Poynard T,Munteanu M,Imbert-Bismut F,et al.Prospe-ctive analysis of discordant results between biochemicalmarkers and biopsy in patients with chronic hepatitis C[J].Clinical Chemistry,2004,50(8):1344-1355.
    [14]Romero Gómez M,Ramírez Martín del Campo M,OteroMA,et al.Comparative study of two models that usebiochemical parameters for the noninvasive diagnosisof fibrosis in patients with hepatitis C[J].Med Clin,2005,124(20):761-764.
    [15]Marín-Gabriel JC,Solís-Herruzo JA.Noninvasiveassessment of liver fibrosis.Serum markers andtransient elastography(FibroScan)[J].Rev Esp EnfermDig,2009,101(11):787-799.
    [16]Poon TC,Hui AY,Chan HL,et al.Prediction of liverfibrosis and cirrhosis in chronic hepatitis B infection byserum proteomic FIngerprinting:a pilot study[J].ClinChem,2005,51(2):328-335.
    [17]Morra R,Munteanu M,Bedossa P,et al.Diagnostic value ofserum protein profiling by SELDI-TOF ProteinChip comparedwith a biochemical marker,FibroTest,for the diagnosis ofadvanced fibrosis in patients with chronic hepatitis C[J].Aliment Pharmacol Ther,2007,26(6):847-858.
    [18]Callewaert N,Vlierberghe HV,Hecke AV,et al.Noninvasive diagnosis of liver cirrhosis using DNAsequencer-based total serum protein glycomics[J].NatMed,2004,10(4):429-434.
    [19]Chen CY,Schmilovitz-Weiss H,Liu XE,et al.Serumprotein N-Glycans Profiling for the discovery of potentialbiomarkers for nonalcoholic steatohepatitis[J].JProteome Res,2009,8(2):463-470.
    [20]Lim AK,Taylor-Robinson SD,Patel N,et al.Hepatic veintransit times using a microbubble agent can predictdisease severity non-invasively in patients with hepatitisC[J].Gut,2005,54(1):128-133.
    [21]Janssens F,de Suray N,Piessevaux H,et al.Cantran-sient elastography replace liver histology fordetermination of advanced fibrosis in alcoholic patients:A real-life study[J].Clin Gastroenterol,2010[Epubahead of print].
    [22]Castera L.Transient elastography and other noninvasivetests to assess hepatic fibrosis in patients with viralhepatitis[J].J Viral Hepat,2009,16(5):300-314.
    [23]Bonnard P,SombiéR,Lescure FX,et al.Comparison ofelastography,serum marker scores,and histology for theassessment of liver fibrosis in hepatitis B virus(HBV)-infected patients in Burkina Faso[J].Trop Med Hyg,2010,82(3):454-458.
    [24]Huwart L,Sempoux C,Vicaut E,et al.Magnetic resonan-ce elastography for the noninvasive staging of liverfibrosis[J].Gastroenterology,2008,135(1):32-40.
    [25]RouvièreO,Yin M,Dresner MA,et al.MR elastographyof the liver:preliminary results[J].Radiology,2006,240(2):440-448.
    [26]Yin M,Talwalkar JA,Glaser KJ,et al.Assessment ofhepatic fibrosis with magnetic resonance elastography[J].Clin Gastroenterol Hepatol,2007,5(10):1207-1213.
    [27]Faria SC,Ganesan K,Mwangi DI,et al.MR Imagingof Liver Fibrosis:Current State of the Art[J].RadioGraphics,2009,29(6):1615-1635.
    [28]Lewin M,Poujol-Robert A,Boelle PY,et al.Diffusion-weighted magnetic resonance imaging for theassessment of fibrosis in chronic hepatitis C[J].Hepatology,2007,46(3):658-665.
    [29]Taouli B,Koh DM.Diffusion-weighted MR Imaging of theLiver[J].Radiology,2010,254(1):47-66.
    [30]Taouli B,Tolia AJ,Losada M,et al.Diffusion-weighted MRIfor quantifcation of liver fbrosis:preliminary experience[J].AJR Am J Roentgenol,2007,189(4):799-806.
    [31]Boulanger Y,Amara M,Lepanto L,et al.Diffusion-weighted MR imaging of the liver of hepatitis Cpatients[J].NMR Biomed,2003,16(3):132-136.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3715) PDF downloads(1053) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return