中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2011

Value of autoantibodies in predicting autoimmune liver disease

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  • Published Date: 2011-03-20
  • Autoantibodies have been widely used in autoimmune liver disease as diagnostic markers, but the value of estimating disease severity and prognosis has not been commonly comprehended.Actually, autoantibodies are valuable in predicting disease severity and treatment outcome as well as directing the diagnosis.Antibodies to soluble liver antigen, actin, liver cytosol type 1, asialoglycoprotein receptor, chromatin, cyclic citrullinated peptide, and uridine glucuronosyltransferases have been considered to be associated with the occurrence, severity and progression of autoimmune hepatitis.For example, antibody to soluble liver antigen is associated with severe histological changes, long durations of treatment, relapse after drug withdrawal and high frequency of liver failure.Besides, antibodies to Sp100, gp210 and centromere have prognostic value in primary biliary cirrhosis, for instance, antibody to gp210 is associated with severe interface hepatitis, lobular inflammation, and progression to liver failure.

     

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