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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2011
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Detection of HBV-LP and relationships between HBV DNA and its level in HBV patients with different patterns of HBV Markers

  • Published Date: 2011-08-20
  • Objective To investigate the relationship between HBV large envelop protein (HBV-LP) and HBV DNA/patterns of HBV markers and the significances of HBV-LP in clinical diagnosis and treatment of HBV patients, the HBV-LP, preS1 and HBV DNA in HBV patients with different patterns of HBV markers (HBV M, HBsAg/HBsAb、HBeAg/HBeAb、HBcAb) were tested.Methods The HBV-LP, preS1 and patterns of HBV M were tested by ELISA, and HBV DNA was measured by fluorescence quantitative PCR.Results No significant difference was found between HBV-LP and HBV DNA level (χ2=1.97, P>0.05) .There was a positive correlation with the value A of HBV-LP and the HBV DNA level (r=0.565, P<0.01) , and there was a significant difference of value A of HBV-LP in different copies of HBV DNA (F=9.23, P<0.01) .Conclusion The HBV-LP was a good sero-immunological marker to reflect the level of virus replication in HBV patients.The HBV-LP in serum has a good positive correlation with HBV DNA, and especially served as a good serum target in monitoring the virus replication and prognosis.

     

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