中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2011
Turn off MathJax
Article Contents

The expression of HMGB1 in hepatocellular carcinoma, paracancerous liver tissue and its significance

  • Published Date: 2011-08-20
  • Objective To investigate the expression of high mobility group box 1 protein (HMGB1) in different liver tissue and its relationship with liver tissue injury and hepatocarcinogenesis as well as development.Methods 20 hepatocellular carcinoma and 20 paracancerous tissues specimens were incorporated in this study.Chemicopathological method was used to evaluate the hepatic inflammation degree and fibrosis stage in 46 CHB and 20 para-cancerous tissues;immunohistochemical method was used to detect the expression of HMGB1 in the above liver tissues.Results There was significant difference in the expression of HMGB1 among normal liver, chronic hepatitis B, paracancer tissue and tumor tissue (H=7.29, P=0.027) ;There was a rank correlation between different grade of liver inflammation and the expression level of HMGB1 (rs=0.318, P=0.031) ;There was a rank correlation between varying degrees of liver fibrosis and the expression of HMGB1 (rs=0.296, P= 0.042) ;There was no rank correlation between the HMGB1 expression in hepatocellular carcinoma and Edmondson (rs=0.206, P>0.05) .Conclusion HMGB1 would be an indirect indicators of liver inflammation and fibrosis and closely related to the development of liver cancer.

     

  • loading
  • [1]Wang H, Yang H, Tracey KJ.Extracellular role of HMGB1 in in-flammation and sepsis[J].J Intern Med, 2004, 255 (3) :320-331.
    [2]赵雷, 刘靖华, 唐靖, 等.人高迁移率族蛋白1的原核细胞表达及其功能研究[J].中国病理生理杂志, 2006, 22 (6) :1119-1123.
    [3]王树彦, 陈宗祐.高迁移率族蛋白1与肿瘤[J].上海医学, 2009, 32 (8) :757-760.
    [4] 中华医学会.慢性乙型肝炎防治指南[J].胃肠病学, 2006, 11 (9) :550-556.
    [5]中华医学会.病毒性肝炎防冶方案[J].中华肝脏病杂志, 2000, 8 (3) :324-329.
    [6]Ishak K, Baptista A, Bianchi L, et al.Histological grading andstaging of chronic hepatitis[J].J Hepatol, 1995, 22 (4) :696-699.
    [7]Sappington PL, Yang R, Yang H, et al.HMGB l B box increasesthe permeability of Caco-2 enterocytic monolayers and impairs in-testinal barrier function in mice[J].Gastroenterology, 2002, 123 (4) :790-802.
    [8]Sundberg E, Fasth AE, Palmblad K, et al.High mobility group boxchromosomal protein 1 act s as a proliferation signal for activated T lym-phocytes[J].Immunobiology, 2009, 214 (2) :303-309.
    [9]Erlandsson Harris H, Andersson U.Mini review:The nuclear pro-tein HMGB l as a proinflammatory mediator[J].Eur J Immunol, 2004, 34 (6) :1503-1512.
    [10]赵中夫, 韩德五.高迁移率族蛋白B-1及其在肝损伤合并内毒素血症中的作用[J].中华肝脏病杂志, 2006, 14 (9) :718-720.
    [11]刘洪波, 范学工, 黄建军, 等.乙型肝炎患者血清高迁移率蛋白-1含量的检测及临床意义[J].中华肝脏病杂志, 2007, 15 (11) :812-815.
    [12]刘洪波, 范学工, 刘悦晖, 等.肝损伤模型小鼠高迁移率族蛋白-1的表达[J].生命科学研究, 2008, 12 (2) :169-173.
    [13]Müller S, Scaffidi P, Degryse B, et al.New EMBO members’re-view:the double life of HMGB1 chromatin protein:architecturalfactor and extracellular signal[J].EMBO J, 2001, 20 (16) :4337-4340.
    [14]宋舟, 刘屹, 包国强, 等.HMGB1在大肠癌组织中的表达及意义[J].现代肿瘤医学, 2008, 16 (7) :1911-1194.
    [15]Campana L, Bosurgi L, Rovere-Querini P.HMGB1:a two-headed signal regulating tumor progression and immunity[J].CurrOpin Immunol, 2008, 20 (3) :518-523.
    [16]Cheng BQ, Jia CQ, Liu CT et al.Serum high mobility group boxchromosomal protein 1 is associated with clinicopathologic features inpatients with hepatocellular carcinoma[J].Dig Liver Dis, 2008, 40 (6) :446-452.
    [17]Chung Hw, Lee SG, Kim H, et al.Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic featuresof gastric cancer[J].J Transl Med, 2009, 7 (1) :38.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3887) PDF downloads(768) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return