Effect of fenofibrate on serum biochemical indicators and hepatic pathology in rats after bile duct ligation

Objective To investigate the effect of Fenofibrate on serum hepatic biochemical indicators、MDA (malonaldehyde) and hepatic pathology in rats after bile duct ligation.Methods Rats were subjected to bile duct ligation to establish the cholestasis model.Twenty-four male Wistar rats were randomly divided into two groups equally: A = bile duct ligation+normal saline (BDL + NS) , B= BDL + fenofibrate (30 mg/kg daily) .All rats were sacrificed on 7th day after obtaining blood samples and liver tissue.Serum hepatic biochemical indicators were detected with automatic biochemistry analyzer;MDA assays were performed by spectrophotometer;Histopathological changes in liver was dyed with HE and observed under light microscope.Results There was no significant difference in terms of serum hepatic biochemical levels between group A and group B;The levels of MDA in rats of group B were significantly lower than in group A (P=0.001<0.05) ;The number of liver necrotic area in rats of group B was significantly smaller than in group A (P<0.05) , The number of biliary canals in rats of group B was significantly smaller than in group A (P<0.05) .Conclusion Fenofibrate administration attenuates the levels of MDA, reduces liver necrotic area and ductular proliferation.