中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2011

Transcriptional regulation and therapy of hTERT in hepatocellular carcinoma

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  • Published Date: 2011-09-20
  • Unlimited cell proliferation and disabled apoptosis are the most important event and crucial step in the occurrence and development of hepatocellular carcinoma (HCC) .Human telomerase reverse transcriptase (hTERT) and physiological and pathological cell proliferation are closely related, and its transcriptional level is regulated by numerous oncogenes, anti-oncogenes and cytokines.hTERT is related to the occurrence and development of hepatocellular carcinoma.Recently, hTERT-targeted gene therapy has become a novel strategy for the management of HCC.The relationships between the expression of hTERT and the tumor occurrence, progression, prognosis, as well as gene-targeted therapy on the sequence of hTERT for HCC are discussed in this review.

     

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