Therapeutic efficacy of autologous bone marrow stem cells transplantation for treatment of terminal liver disease of 24 cases

Objective To study the effect of autologous bone marrow stem cells (BMSCs) transplantation in the treatment of liver failure and decompensated hepatic cirrhosis.Methods Stem cells were harvested from patients' bone marrow (180-200 ml) by negative collecting method.The stem cells were infused into the liver through hepatic artery.At different time points, the patients liver function, prothrombin activity (PTA) , AFP, liver reserving function, namely indocynine green retention rate at fifteen minutes (ICGR15%) , liver ultrasound and liver CT were detected.Symptoms and adverse reactions were observed at the same time.Results The serum alanine aminotransferase (ALT) levels were significantly declined after transplantation (P<0.05) ;The serum albumin (Alb) 、PTA、cholinesterase (CHE) and AFP levers were significantly increased at 4 weeks、8 weeks and 12weeks after transplantation (P<0.05) ;The serum total bilirubin (TBil) 、ICGR15% were significantly declined at 12 weeks after transplantation (P<0.05) ;and surface area of a branch of the portal were significantly increased at 12 weeks after transplantation (P<0.05) ;After transplantation, all patients' mental、physical strength and appetite were improved, and no complications associated with the transplantation occurred.Conclusion BMSCs transplantation are safe and effective, and can significantly improve the liver function、coagulation and liver reserving function, the size of reduced and increase reduction of liver size.