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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2012
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Alteration and significance of intestinal flora in patients with NASH

  • Published Date: 2012-02-20
  • Objective To investigate alteration and significance of intestinal flora in patients with NASH.Methods Intestinal bacteria were routinely cultured and counted.Thirty health adults, thirty patients with nonalcoholic fatty liver and thirty patients with nonalcoholic steatohepatitis were selected and their intestinal bacteria were detected respectively.Results Alteration of intestinal flora included decrease in anaerobic bacteria (P<0.05) and increase in aerobic bacteria (P<0.05) in patients with NASH.There was no significant change in aerotolerant anaerobe such as toruloid fungi (P>0.05) .Conclusion There is alteration in intestinal flora and overgrowth of gram negative bacilli in patients with NASH.The results suggest that unbalance of intestinal microecology probably involve in the development of NASH.

     

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  • [1]Sheth SG, Cordon FD, Chopra S.Nonacoholic steatohepati-tis[J].Ann Intern Med, 1997, 126 (2) :137-145.
    [2]Vanni E, Bugianesi E.The gut-liver axis in nonalcoholic fat-ty liver disease:another pathway to insulin resistance[J].Hepatology, 2009, 49 (6) :1791-1793.
    [3]中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志, 2010, 18 (3) :163-166.
    [4]Hart AL, Stagg AJ, Frame M, et al.Review article:the roleof the gut flora in health and disease and its modification astherapy[J].Aliment Pharmacol Ther, 2002, 16 (8) :1383-1393.
    [5]B ckhed F, Ding H, Wang T, et al.The gut microbiota as anenvironmental factor that regulates fat storage[J].Proc NatlAcad Sci USA, 2004, 101 (44) :15718-15723.
    [6]Turnbaugb PJ, Ley RE, Mahowald MA, et al.An obesity-associated gut microbiome with increased capacity for energyharvest[J].Nature, 2006, 444 (7122) :1027-1030.
    [7]Cani PD, Amar J, Iglesias MA, et al.Metabolic endotoxemiainitiates obesity and insulin resistance[J].Diabetes, 2007, 56 (7) :1761-1772.
    [8]Wigg AJ, Roberts-Thomson IC, Dymock RB, et al.The role ofsmall intestinal bacterial overgrowth, intestinal permeability, en-dotoxaemia, and tumour necrosis factor alpha in the pathogene-sis of non-alcoholic steatohepatitis[J].Gut, 2001, 48 (20) :206-211.
    [9]Han DW.Intestinal endotoxemia as a pathogenetic mecha-nism in liver failure[J].World J Gastroenterol, 2002, 8 (6) :961-965.
    [10]Yee SB, Harkema JR, Ganey PE, et al.The coagulation sys-tem contributes to synergistic liver injury from exposure tomonocrotaline and bacterial lipopolysaccharide[J].ToxicolSci, 2003, 74 (2) :457-469.
    [11]Hirose M, Nishikawa M, Qian W, et al.Mannose-conjuga-ted alendronate selectively depletes Kupffer cells and inhibitsendotoxemic shock in the mice[J].Hepatol Res, 2006, 36 (1) :3-10.
    [12]Higuchi Y, Kawakami S, Yamashita F, et al.The potentialrole of fucosylated cationic liposome/NFkappaB decoy com-plexes in the treatment of cytokine-related liver disease[J].Biomaterials, 2007, 28 (26) :532-539.
    [13]Day CP, James OF.Steatohepatitis:a tale of two“hits”[J].Gastroenterology, 1998, 114 (4) :842-845.
    [14]范建高.调整肠道微生态平衡-脂肪性肝炎防治的新靶点[J].现代医药卫生, 2007, 23 (3) :317-318
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