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ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 4
Apr.  2012
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Polymorphisms in PNPLA3 gene is associated with non-alcoholic fatty liver disease

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  • Published Date: 2012-04-20
  • Non-alcoholic fatty liver disease (NAFLD) , is the common liver disorder in the Western world and China.However, because the pathogenesis of NAFLD is undear, there is still no effeetive treatment.Provious Studies have pointed that the occurrence of NAFLD is relative with gehetic, enuiron mental and psychological factors.Some studies suggest that genetic factors and genetic polymorphism are related to pathogenesis and development of NAFLD.The genome-wide association studies shoued that the PNPLA3 (patatin like phospholipase domain containing 3) genetic polymorphism are closely linked with NAFLD.This review form several aspects to clarify the association between polymorphism in PNPLA3 gene and development of NAFLD.

     

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