Therapeutic efficacy of telbivudine for treating chronic hepatitis B patients with elevated levels of serum soluble E-selectin

Objective To compare the levels of hepatitis B surface antigen (HBsAg) and serum soluble (s) E-selectin before and after telbivudine (LdT) treatment in patients with chronic hepatitis B (CHB) .Methods One-hundred-and-seven patients with CHB and 82 healthy controls were enrolled in the study.The levels of HBsAg and serum sE-selectin were measured by enzyme-linked immunosorbent assay (ELISA) before and after LdT treatment.The correlation between HBsAg and serum sE-selectin was analyzed by Pearson′s correlation analysis.Results The pre-treatment sE-selectin content of the CHB group was significantly higher than that of the healthy control group (P<0.01) .The levels of both HBsAg and sE-selectin were significantly reduced in the CHB group after treatment with LdT (P<0.01) .The correlation analysis showed that the HBsAg level was positively correlated with the content of sE-selectin (P<0.01) .Conclusion sLdT may inhibit HBV replication by decreasing the serum sE-selectin content, which may lead to an enhanced immune function.