The clinical features and prognosis of sepsis-associated cholestasis in patients with liver cirrhosis

Objective To explore the clinical features and prognosis of cirrhotic patients with concomitant sepsis-associated cholestasis.Methods A retrospective analysis of 180 patients with liver cirrhosis was performed.The clinical data, including infection, age, sex, Child-Pugh classification and antibiotic treatment, were compared between the patients with sepsis-associated cholestasis and those without using the Chi-squared test.Results Sepsis-associated cholestasis occurred in 30% (n=54) of the liver cirrhosis patients.The sepsis-related infections included spontaneous bacterial peritonitis (n=20) , urinary tract infection (n=18) , biliary tract infection (n=6) , intestinal infection (n=4) , pulmonary infection (n=4) , and undetermined infection (n=2) .The sepsis-associated cholestasis group showed significantly older age, higher Child-Pugh score, and increased antibiotics (all, P<0.05) .The mortality rate was significantly higher in the sepsis-associated cholestasis group (16/54 vs.13/126 in the non-septic cholestasis group, P<0.05) .Conclusion Sepsis-associated cholestasis in patients with advanced cirrhosis is associated with a poor prognosis.