Objective To compare the age distributions and presence of hepatitis B virus (HBV) serological markers between primary hepatic cancer (PHC) patients with and without liver cirrhosis.Methods A total of 547 PHC cases were analyzed retrospectively.After dividing into two groups according to liver cirrhosis status, the between-group differences in age and HBV serological markers, such as hepatitis B e antigen (HBeAg) status, were statistically compared using the Chi-squared test.Results The number of cirrhotic and non-cirrhotic PHC patients was 265 and 282, respectively.HBV infection was present in 221 cirrhotic PHC patients and 256 non-cirrhotic PHC patients (83.4% vs.90.8%) .There was a substantial bias in the proportion of males to females in the cirrhotic PHC patients (7.83∶ 1) .The number of PHC patients<60 years="" old="" was="" similar="" between="" the="" cirrhotic="" and="" non-cirrhotic="" but="" group="" had="" significantly="" more="" patients="">60 years old (P<0.005) .In cirrhotic PHC patients, the HBV infection rate was highest in the <40 years old age group (96.7%) and the HBeAg serological conversion rate was highest in the 40-60 years old age group (89.5%) .In non-cirrhotic PHC patients, the 40-60 years old age group showed the highest HBV infection rate (90.3%) but the lowest HBeAg serological conversion rate (80.0%) .Conclusion PHC with liver cirrhosis mainly occurred in males, with the HBV infection rate being higher in individuals <60 years="" old.non-cirrhotic="" phc="" patients="" were="" more="" often="">60 years old.Many of the HBV-infected PHC patients with cirrhosis had high HBeAg serological conversion rate.
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