2015 No. 6

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Editorial

Current challenges to primary liver cancer research

Ye ShengLong

2015, 31(6): 819-823. DOI: 10.3969/j.issn.1001-5256.2015.06.001

Abstract(342)

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Abstract:
Primary liver cancer is a common malignancy with increasing incidence and mortality. Remarkable progress has been made in the clinical research on liver cancer,but challenges to further improvement are still rigorous. This article reviews the progress and difficulties of primary liver cancer study f...

Therapeutic guidelines

Policybrief: Guidelines for the prevention, care, and treatment of chronic hepatitis B virus infection(march 2015)

World Health Organization

2015, 31(6): 824-828. DOI: 10.3969/j.issn.1001-5256.2015.06.002

Abstract(186)

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Abstract:

Explanation of the “Guidelines for the prevention,care and treatment of persons with chronic hepatitis B infection 2015”: non-invasive assessment of liver fibrosis,treatment strategy and implementation of national programs

Hu XiaoYun, Liu ZhiHong, Sun Jian

2015, 31(6): 829-832. DOI: 10.3969/j.issn.1001-5256.2015.06.003

Abstract(341)

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Abstract:

Evidence-based practice guidelines for the standardized pathological diagnosis of primary liver cancer in China( 2015 update)

Chinese Society of Liver Cancer, Chinese Anti-Cancer Association, Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Pathology, Chinese Anti-Cancer Association, Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association, epatic Surgery Group, Chinese Society of Surgery, Chinese Medical Association, Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association, Chinese Pathological Group of Hepatobiliary Tumor and Liver Transplantation

2015, 31(6): 833-839. DOI: 10.3969/j.issn.1001-5256.2015.06.004

Abstract(729)

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Abstract:

Updated key points and clinical pathway for NCCN Clinical Practice Guidelines in Oncology: hepatobiliary cancers(Version 2. 2015)

Zhu Peng, Xu Zong, Wang YuMing

2015, 31(6): 840-849. DOI: 10.3969/j.issn.1001-5256.2015.06.005

Abstract(267)

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Abstract:

Interpretation of key points in Evidence-based Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2013 update (3rd JSH-HCC Guidelines)

Wu YinLian, Lin Su, Dong Jing, Jiang JiaJi

2015, 31(6): 850-851. DOI: 10.3969/j.issn.1001-5256.2015.06.006

Abstract(331)

PDF (545KB)(154)

Abstract:

UK guidelines on the management of variceal haemorrhage in cirrhotic patients (2015): an excerpt of recommendations

Deng Han, Qi XingShun, Guo XiaoZhong

2015, 31(6): 852-854. DOI: 10.3969/j.issn.1001-5256.2015.06.007

Abstract(3239)

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Abstract:

Discussions by experts

Significance of predictive models / risk calculators for HBV-related hepatocellular carcinoma

Dong Jing, Jiang JiaJi

2015, 31(6): 855-858. DOI: 10.3969/j.issn.1001-5256.2015.06.008

Abstract(3001)

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Abstract:
Hepatitis B virus( HBV)- related hepatocellular carcinoma( HCC) is a major public health problem in Southeast Asia. In recent years,researchers from Hong Kong and Taiwan have reported predictive models or risk calculators for HBV- associated HCC by studying its natural history,which,to some extent,p...

Surgical treatment of hepatocellular carcinoma with portal vein tumor thrombus

Jia WeiDong, Liu WenBin

2015, 31(6): 859-862. DOI: 10.3969/j.issn.1001-5256.2015.06.009

Abstract(2933)

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Abstract:
Portal vein tumor thrombus( PVTT) is one of the important biological characteristics of hepatocellular carcinoma( HCC),and also a serious complication and a metastatic mode. Surgical treatment is still the most effective therapy for HCC with PVTT. This article describes the history and present situa...

Comprehensive interventional treatment of hepatocellular carcinoma with portal vein tumor thrombosis

Zhu XiaoLi

2015, 31(6): 863-869. DOI: 10.3969/j.issn.1001-5256.2015.06.010

Abstract(3177)

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Abstract:
Portal vein tumor thrombosis( PVTT) often occurs in advanced hepatocellular carcinoma( HCC) patients. PVTT may cause tumor dissemination,liver failure,and portal hypertension,thus leading to intractable ascites,variceal rupture,and hepatic encephalopathy,which will result in a poor prognosis. Accord...

A novel approach for treating hepatocellular carcinoma: epigenetic therapy

Li Qiang, Chen Liang, Huang YuXian

2015, 31(6): 870-875. DOI: 10.3969/j.issn.1001-5256.2015.06.011

Abstract(381)

PDF (274KB)(256)

Abstract:
Recent studies have shown that the pathophysiology of hepatocellular carcinoma( HCC) involves epigenetic alterations in DNA methylation,histone modifications,and microRNAs. In this review,we describe the general characteristics of epigenetic machinery in HCC as well as the current advances in epigen...

Hepatic stellate cells,Toll-like receptor 4 signaling pathway,and inflammatory fibrotic microenvironment in the development of hepatocellular carcinoma

Wu YuJing, Guo JinSheng

2015, 31(6): 876-879. DOI: 10.3969/j.issn.1001-5256.2015.06.012

Abstract(2835)

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Abstract:
The development of hepatocellular carcinoma( HCC) is closely related to the precancerous microenvironment of inflammation and fibrosis. The activated hepatic stellate cells( HSCs) are the major source of extracellular matrix in the development of liver fibrosis and the key effective cells of hepatic...

Original articles_Liver neoplasms

Efficacy of transcatheter arterial chemoembolization alone or combined with microwave ablation in treatment of primary large liver cancer: a comparative analysis

Chang Peng, Zhang HongYi, Xiao Mei

2015, 31(6): 880-885. DOI: 10.3969/j.issn.1001-5256.2015.06.013

Abstract(2970)

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Abstract:

Objective To retrospectively analyze the short- term efficacy and long- term survival rates of transcatheter arterial chemoembolization( TACE) combined with percutaneous microwave coagulation therapy( PMCT) versus TACE monotherapy in the treatment of large primary hepatic carcinoma. Methods Sixty- s...

Efficacy and prognostic factors of intensity-modulated radiotherapy for large primary hepatocellular carcinoma

Fang ZiYan, Jin Shuai, Li Gong

2015, 31(6): 886-890. DOI: 10.3969/j.issn.1001-5256.2015.06.014

Abstract(3269)

PDF (1452KB)(635)

Abstract:

Objective To investigate the efficacy of intensity- modulated radiotherapy( IMRT) in treating large primary hepatocellular carcinoma( LHCC) which is unsuitable for surgery or has poor response to radiofrequency ablation,interventional therapy,and other local treatments,and to identify the prognostic...

Therapeutic effect and prognostic analysis of intensity-modulated radiotherapy for primary hepatocellular carcinoma with portal vein and / or inferior vena cava tumor thrombus

Huang Long, Qi Liang, Li Gong

2015, 31(6): 891-894. DOI: 10.3969/j.issn.1001-5256.2015.06.015

Abstract(3311)

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Abstract:

Objective To determine the efficacy and prognostic factors of intensity- modulated radiotherapy( IMRT) for primary hepatocellular carcinoma( HCC) with portal vein and / or inferior vena cava tumor thrombus. Methods Twenty- three HCC patients with portal vein and / or inferior vena cava tumor thrombu...

Efficacy of sorafenib combined with capecitabine in Hui versus Han residents with advanced hepatocellular carcinoma in Sanya,Hainan,China: a comparative analysis

Chen Long, Liang Dong, Hou BenXin, Feng Jun, Lin YongPing, Lu ZhiCheng

2015, 31(6): 895-898. DOI: 10.3969/j.issn.1001-5256.2015.06.016

Abstract(3208)

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Abstract:

Objective To compare the clinical efficacy of sorafenib combined with capecitabine in Hui versus Han residents with advanced hepatocellular carcinoma( HCC) in Sanya,Hainan,China. Methods A total of 96 Hui and Han residents with advanced HCC took oral capecitabine 1500 mg / m2 twice daily for 14 days...

Ultrasound-guided percutaneous cinobufagin injection for treatment of portal vein tumor thrombus in primary liver cancer patients

Ji JianFeng, Deng XiaoLi, Xiao QiuJin, Yang Xue

2015, 31(6): 899-902. DOI: 10.3969/j.issn.1001-5256.2015.06.017

Abstract(2828)

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Abstract:

Objective To evaluate the clinical value of ultrasound- guided percutaneous cinobufagin injection for the treatment of portal vein tumor thrombus( PVTT) in primary liver cancer( PLC) patients. Methods A total of 25 PLC patients with PVTT who were admitted to our hospital from January 2009 to March 2...

Relationship between tumor location and pain level in CT-guided percutaneous microwave ablation of hepatocellular carcinoma

Li JingHua, Cui ShiChang, Sun Jian, Fang Da, Du Ning, Zheng JiaSheng, Cui XiongWei

2015, 31(6): 903-906. DOI: 10.3969/j.issn.1001-5256.2015.06.018

Abstract(2880)

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Abstract:

Objective To investigate the relationship between tumor location and pain level in computed tomography( CT)- guided percutaneous microwave ablation( MWA) of hepatocellular carcinoma( HCC) under local anesthesia. Methods A total of 42 tumors in 35 HCC patients were given CT- guided percutaneous MWA u...

Clinical characteristics of patients with HBs Ag( + ) versus HBs Ag(-) / HBc Ab( + ) primary hepatic carcinoma treated by hepatectomy: a comparative analysis

Yang KeLi, Yang Zhan, Guan YuJuan, Ying RuoSu, Li JianPing

2015, 31(6): 907-909. DOI: 10.3969/j.issn.1001-5256.2015.06.019

Abstract(2012)

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Abstract:

Objective To explore the differences in clinical characteristics between patients with HBs Ag( +) and HBs Ag(-) / HBc Ab( +) primary hepatic carcinoma( PHC) treated by hepatectomy. Methods Forty- three HBs Ag( +) and 18 HBs Ag(-) /HBc Ab( +)patients who underwent liver resection against PHC from Oct...

Usage analysis of human serum albumin in patients with liver cancer and liver cirrhosis after hepatectomy

Huang DongHai, Shi JianShe, Zhang ChengHua

2015, 31(6): 910-914. DOI: 10.3969/j.issn.1001-5256.2015.06.020

Abstract(2151)

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Abstract:

Objective To analyze the usage of human serum albumin in patients with liver cancer and liver cirrhosis after hepatectomy.Methods A total of 121 patients with liver cancer and liver cirrhosis who received hepatectomy in our hospital from January 2012 to January2014 were divided into control group( n...

Clinical analysis of blood amino acids and trace elements in patients with hepatocellular carcinoma

Zhao YuPing, Han XiuQing, Xue ShuBao, Xiao FengYan, Gao CuiHong, Zhao LiMei

2015, 31(6): 915-917. DOI: 10.3969/j.issn.1001-5256.2015.06.021

Abstract(1965)

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Abstract:

Objective To investigate the characteristics of trace elements and amino acid metabolism in the blood of patients with hepatocellular carcinoma( HCC) and to guide clinical treatment. Methods This study included 125 untreated patients with primary HCC in Tangshan Maternal and Child Health Hospital an...

Therapeutic comparison between radiofrequency ablation and percutaneous ethanol injection in treatment of primary liver cancer: a meta-analysis

Yin Yu, Ni CaiFang, Li Zhi, Tang Jie

2015, 31(6): 918-921. DOI: 10.3969/j.issn.1001-5256.2015.06.022

Abstract(2198)

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Abstract:

Objective To compare the efficacy of radiofrequency ablation( RFA) versus percutaneous ethanol injection( PEI) in the treatment of primary liver cancer( PLC). Methods A search of Pub Med,EMBASE,CKNI,VIP,and Wanfang Data identified all randomized controlled trials( RCTs) related to therapeutic compar...

Efficacy and safety of octreotide in treatment of hepatocellular carcinoma: a meta-analysis

Zhang YuHuai, Luo ZhangJiang

2015, 31(6): 922-926. DOI: 10.3969/j.issn.1001-5256.2015.06.023

Abstract(2169)

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Abstract:

Objective To systematically evaluate the efficacy and safety of octreotide in the treatment of hepatocellular carcinoma( HCC).Methods Online databases including Pub Med,Cochrane Library,Embase,China National Knowledge Internet,Wanfang Data,and China Science and Technology Journal Database were compr...

Preoperative neutrophil-lymphocyte ratio is an independent prognostic factor for hepatocellular carcinoma after radical resection

Zhang TingTing, Zhao XiangQian, Liu Zhe, Jiao ShunChang, Bai Li

2015, 31(6): 927-931. DOI: 10.3969/j.issn.1001-5256.2015.06.024

Abstract(2047)

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Abstract:

Objective To evaluate the effect and predictive value of preoperative neutrophil- lymphocyte ratio( NLR) on the prognosis of patients undergoing radical resection for hepatocellular carcinoma( HCC). Methods The clinical data of 245 patients who received radical resection for HCC in our hospital from...

Han Zhen, Sun HuanQin, Jiang Na, Liu Ning, Xu Jie, Sun JianPing, Zhang YongHong

2015, 31(6): 932-935. DOI: 10.3969/j.issn.1001-5256.2015.06.025

Abstract(2197)

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Abstract:

Objective To investigate the expression levels of angiogenesis- related factors in various clinical stages of hepatitis B- related hepatocellular carcinoma( HCC) and their clinical significance. Methods Seventy patients with hepatitis B- related HCC who were admitted to our hospital from 2011 to 201...

Correlation between interleukin-6 and primary hepatocellular carcinoma: a meta-analysis

Li Xia, Shi YongYu

2015, 31(6): 936-942. DOI: 10.3969/j.issn.1001-5256.2015.06.026

Abstract(2163)

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Abstract:

Objective To evaluate the correlation between interleukin( IL) 6 and primary hepatocellular carcinoma( HCC). Methods Case- control studies that included quantitative data on plasma or serum IL- 6 levels of patients with HCC were identified from Pub Med,ISI Web of Knowledge,CBM,and CNKI. A meta- anal...

Effects of PARP-1 inhibitors AG-014699 and AZD2281 on proliferation and apoptosis of human hepatoma cell line HepG2

Du SenRong, Mao XiaoRong, Xiao Ping, Chen Hong

2015, 31(6): 943-946. DOI: 10.3969/j.issn.1001-5256.2015.06.027

Abstract(2091)

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Abstract:

Objective To observe the inhibitory and pro- apoptotic effects of two poly( ADP- ribose) polymerase( PARP- 1) inhibitors,AG- 014699 and AZD2281,on human hepatoma Hep G2 cells and preliminarily explore the mechanism by which AG- 014699 induces Hep G2 cell apoptosis,and to provide a new therapeutic ta...

Original articles_Liver fibrosis and liver cirrhosis

Mirabilite umbilical compress in treatment of ascites in liver cirrhosis: a meta-analysis

Zhang WenWen, Qi XingShun, Guo XiaoZhong

2015, 31(6): 947-950. DOI: 10.3969/j.issn.1001-5256.2015.06.028

Abstract(2238)

PDF (1756KB)(487)

Abstract:
Objective To systematically evaluate the efficacy of mirabilite umbilical compress in the treatment of ascites in liver cirrhosis.Methods The literature on the treatment of cirrhotic ascites with mirabilite umbilical compress was searched in CNKI,VIP,Wanfang Data,and Pub Med databases. A meta- analy...

Original articles_Biliary diseases

Effects of conventional versus laparoscopic surgery in treatment of congenital bile duct dilatation: a comparative analysis

Chen HouBin, Huang Wei

2015, 31(6): 951-954. DOI: 10.3969/j.issn.1001-5256.2015.06.029

Abstract(2065)

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Abstract:
Objective To compare the clinical effects of conventional versus laparoscopic surgery in adults with congenital bile duct dilatation. Methods A retrospective analysis was performed on the clinical data of 37 patients with congenital bile duct dilation who were treated in our hospital from February 2...

Original articles_Others

Investigation of impairment of liver function in local residents of Miaofeng Village,Wushan County,China

Yang ZhongXia, Mao XiaoRong, Yuan Hong

2015, 31(6): 955-957. DOI: 10.3969/j.issn.1001-5256.2015.06.030

Abstract(1921)

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Abstract:

Objective To assess the impairment of liver function and investigate possible causes in local residents in Miaofeng Village,Mali Town,Wushan County,Gansu Province,China,and to provide a basis for the etiological study of idiopathic liver damage. Methods The residents in Miaofeng Village were screene...

Case reports

Diagnosis and treatment of hepatocellular carcinoma after 8-year treatment of decompensated HBV-related liver cirrhosis: a report of one case

Hao Juan, Xing Feng, Zhao ZhiMin, Guo ShaoWen, Liu ChengHai

2015, 31(6): 958-960. DOI: 10.3969/j.issn.1001-5256.2015.06.031

Abstract(2469)

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Abstract:

A case of hepatic epithelioid hemangioendothelioma

Wang FengJiao, Liu KaiYan, Qi Yue, Cai YanJun, Li WanYu

2015, 31(6): 961-962. DOI: 10.3969/j.issn.1001-5256.2015.06.032

Abstract(2299)

PDF (1768KB)(543)

Abstract:

Systemic sclerosis with gallbladder stone disease: a report of one case

Dai ShuLong, Yang ShiYong, Yang KunXing

2015, 31(6): 963-964. DOI: 10.3969/j.issn.1001-5256.2015.06.033

Abstract(2581)

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Abstract:

Reviews

Progress in comprehensive treatment of primary liver cancer

Zhu PuLi, Yin Chao, Feng JianLong

2015, 31(6): 965-968. DOI: 10.3969/j.issn.1001-5256.2015.06.034

Abstract(2977)

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Abstract:
The therapeutic methods for the treatment of primary liver cancer is in abundant supply,yet the prognosis far from satisfactory.The article mainly introduces the progress in hepatectomy,liver transplantation,ablation therapy,interventional therapy,radiotherapy,drug therapy,and biological immunity in...

The progress of Fibro Scan technique for diagnosis of hepatocellular carcinoma value

Li Mi, Nie QingHe

2015, 31(6): 969-973. DOI: 10.3969/j.issn.1001-5256.2015.06.035

Abstract(2783)

PDF (1437KB)(603)

Abstract:
Hepatocellular carcinoma( HCC) is one of the most common cancer worldwide,it considers that HCC arises in a background of cirrhosis or chronic infection with hepatitis virus. Liver stiffness assessed by transient elastography is described as a potential risk factor for HCC in cirrhosis. The techniqu...

New progress in treatment of hepatocellular carcinoma with portal vein tumor thrombus

Chen Peng, Li Fei

2015, 31(6): 974-976. DOI: 10.3969/j.issn.1001-5256.2015.06.036

Abstract(1937)

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Abstract:
Portal vein tumor thrombus( PVTT) is one of the common manifestations in patients with advanced hepatocellular carcinoma( HCC). It is the decisive factor leading to severe complications and causes extremely poor prognosis. With the development of molecular biology and imaging techniques,both single ...

Diagnosis and treatment of hepatocellular carcinoma from a new perspective of miRNAs

Li Qiang, Zhuo QiBin, Huang YuXian, Chen Liang

2015, 31(6): 977-981. DOI: 10.3969/j.issn.1001-5256.2015.06.037

Abstract(2031)

PDF (1421KB)(498)

Abstract:
The hepatocellular carcinoma( HCC) diagnosed by serum biomarkers is usually at late stages,and the five- year survival rate of HCC is extremely low. Therefore,it is necessary to develop an efficient and noninvasive biomarker that can detect HCC at an early stage and to explore a new strategy for the...

Research progress in c-Met and hepatocellular carcinoma

Wang ZhangQing, Guo WeiWei, Liu Zheng

2015, 31(6): 982-984. DOI: 10.3969/j.issn.1001-5256.2015.06.038

Abstract(2195)

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Abstract:
c- Met plays a pivotal role in the development and progression of hepatocellular carcinoma( HCC),which can lead to proliferation,survival,cytoskeleton reorganization,separation and diffusion,and angiogenesis of tumor cells. Moreover,c- Met is an important prognostic factor for HCC. In HCC,c- Met act...

Clinical research progress in Erlotinib treatment for hepatocellular carcinoma

Gao Fan, Qi XingShun

2015, 31(6): 985-988. DOI: 10.3969/j.issn.1001-5256.2015.06.039

Abstract(2765)

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Abstract:
Erlotinib achieves antitumor activity by selective inhibition of the epidermal growth factor receptor. This paper summarizes the results of phase Ⅱ- Ⅲ clinical trials of erlotinib in the treatment of hepatocellular carcinoma( HCC). Two phase Ⅱ clinical trials demonstrated the modest antitumor activi...

PI3K / Akt / mTOR signaling pathway and malignant hepatobiliary tumors

Chen XuXiao, Chen YongJun

2015, 31(6): 989-991. DOI: 10.3969/j.issn.1001-5256.2015.06.040

Abstract(2917)

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Abstract:
Phosphoinositide- 3 kinase / protein kinase- B / mammalian target of rapamycin( PI3 K / Akt / m TOR) signaling pathway is involved in many important biological processes such as cell metabolism,growth,proliferation,and angiogenesis. And its high- level activation is closely related to the developmen...

Prevention and treatment of liver fibrosis by regulating liver regeneration

Li HanMin

2015, 31(6): 992-995. DOI: 10.3969/j.issn.1001-5256.2015.06.041

Abstract(2977)

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Abstract:
Liver fibrosis is regarded as a form or status of liver regeneration disorder. Therefore,from a new perspective of regulating liver regeneration,we put forward a new strategy for the prevention and treatment of liver fibrosis. This strategy not only focuses on confrontational reverse regulation,but ...

Application of hepatobiliary-specific MRI contrast agent Gd-EOB-DTPA in preoperative evaluation of hepatobiliary patients

Jiang JiaYun, Li XueSong, Ma KuanSheng

2015, 31(6): 996-999. DOI: 10.3969/j.issn.1001-5256.2015.06.042

Abstract(2712)

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Abstract:
Gd- EOB- DTPA,a newly applicable hepatocyte- specific contrast agent,is excreted through the biliary tract and the kidney,showing the characteristics of nonspecific extracellular contrast agent and hepatocyte- specific contrast agent. It can provide both dynamic and hepatobiliary images and has been...