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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2015
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Article Contents

Application of hepatobiliary-specific MRI contrast agent Gd-EOB-DTPA in preoperative evaluation of hepatobiliary patients

DOI: 10.3969/j.issn.1001-5256.2015.06.042
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  • Received Date: 2014-10-29
  • Published Date: 2015-06-20
  • Gd- EOB- DTPA,a newly applicable hepatocyte- specific contrast agent,is excreted through the biliary tract and the kidney,showing the characteristics of nonspecific extracellular contrast agent and hepatocyte- specific contrast agent. It can provide both dynamic and hepatobiliary images and has been rapidly accepted by clinicians for the diagnosis of liver lesions and preoperative evaluation. Gd- EOB-DTPA can fulfill hepatic perfusion imaging,cholangiography,detection and characterization of focal liver lesions,and evaluation of liver function within the same examination in a relatively short time window. A large number of domestic and foreign studies have confirmed that hepatobiliary- specific contrast- enhanced MRI is significantly superior to MRI scan,contrast- enhanced CT,and ultrasound in diagnosing hepatocellular carcinoma,especially small hepatocellular carcinoma. The features of Gd- EOB- DTPA and its current status and prospect of application in the preoperative evaluation of hepatocellular carcinoma are reviewed in this article.

     

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  • [1]PURYSKO AS,REMER EM,VENIERO JC.Focal liver lesion detection and characterization with GD-EOB-DTPA[J].Clin Radiol,2011,66(7):673-684.
    [2]FRERICKS BB,LODDENKEMPER C,HUPPERTZ A,et al.Qualitative and quantitative evaluation of hepatocellular carcinoma and cirrhotic liver enhancement using Gd-EOB-DTPA[J].AJR Am J Roentgenol,2009,193(4):1053-1060.
    [3]CHANYAPUTHIPONG J,LOW SC,CHOW PK.Gadoxetate acid-Enhanced MR imaging for HCC:a review for clinicians[J].Int J Hepatol,2011,2011:489342.
    [5]GOLFIERI R,RENZULLI M,LUCIDI V,et al.Contribution of the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI to Dynamic MRI in the detection of hypovascular small(≤2 cm)HCC in cirrhosis[J].Eur Radiol,2011,21(6):1233-1242.
    [6]LEE JH,LEE JM,KIM SJ,et al.Enhancement patterns of hepatocellular carcinomas on multiphasic multidetector row CT:comparison with pathological differentiation[J].Br J Radiol,2012,85(1017):e573-e583.
    [7]LEE SA,LEE CH,JUNG WY,et al.Paradoxical high signal intensity of hepatocellular carcinoma in the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI:initial experience[J].Magn Reson Imaging,2011,29(1):83-90.
    [8]NARITA M,HATANO E,ARIZONO S,et al.Expression of OATP1B3determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma[J].J Gastroenterol,2009,44(7):793-798.
    [9]ZECH CJ,GRAZIOLI L,JONAS E,et al.Health-economic evaluation of three imaging strategies in patients with suspected colorectal liver metastases:Gd-EOB-DTPA-enhanced MRI vs.extracellular contrast media-enhanced MRI and 3-phase MDCT in Germany,Italy and Sweden[J].Eur Radiol,2009,19(Suppl 3):s753-s763.
    [10]RIMOLA J,FORNER A,REIG M,et al.Cholangiocarcinoma in cirrhosis:Absence of contrast washout in delayed phases by magnetic resonance imaging avoids misdiagnosis of hepatocellular carcinoma[J].Hepatology,2009,50(3):791-798.
    [11]DOO KW,LEE CH,CHOI JW,et al.“Pseudo washout”sign in high-flow hepatic hemangioma on gadoxetic acid contrast-en-hanced MRI mimicking hypervascular tumor[J].AJR Am J Roentgenol,2009,193(6):w490-w496.
    [12]ZECH CJ,GRAZIOLI L,BREUER J,et al.Diagnostic performance and description of morphological features of focal nodular hyperplasia in Gd-EOB-DTPA-enhanced liver magnetic resonance imaging:results of a multicenter trial[J].Invest Radiol,2008,43(7):504-511.
    [13]TANIMOTO A,MIN LEE J,MURAKAMI T,et al.Consensus report of the 2nd International Forum for Liver MRI[J].Eur Radiol,2009,19(Suppl 5):975-989.
    [14]van BEERS BE,PASTOR CM,HUSSAIN HK.Primovist,Eovist:what to expect?[J].J Hepatol,2012,57(2):421-429.
    [15]LEE NK,KIM S,LEE JW,et al.Biliary MR imaging with GdEOB-DTPA and its clinical applications[J].Radiographics,2009,29(6):1707-1724.
    [16]LLADL,FIGUERAS J,MEMBA R,et al.Is MELD really the definitive score for liver allocation?[J].Liver Transpl,2002,8(9):795-798.
    [17]LI JF,HU YQ,HE SQ.Research progress in evaluation of liver reserve founction[J].China Med Heral,2013,10(24):41-44.(in Chinese)李江发,胡虞乾,何松青.肝脏储备功能评估的研究进展[J].中国医药导报,2013,10(24):41-44.
    [18]TANG F,LIU H.Research developrnent of Gd-EOB-DTPA in evaluation of liver function[J].Chin J Med Imaging Tednol,2014,30(6):939-942.(in Chinese)唐菲,刘辉.新型磁共振对比剂Gd-EOB-DTPA用于评估肝功能研究进展[J].中国医学影像技术,2014,30(6):939-942.
    [19]RYEOM H,KIM S,KIM J,et al.Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA[J].Korean J Radiol,2004,5(4):231-239.
    [20]JIANG J,YE JJ,LIU GY,et al.Visualization of the biliary ducts on contrast enhanced MR chlangiography with Gd-EOB-DTPA:reloation with liver function in patients with liver cirrhosis[J].Chin J Med Imaging Tednol,2013,29(5):765-769.(in Chinese)蒋健,叶健军,刘光耀,等.Gd-EOB-DTPA增强MR胆管成像对胆管的显示与肝硬化患者肝功能的关系[J].中国医学影像技术,2013,29(5):765-769.
    [21]KATSUBE T,OKADA M,KUMANO S,et al.Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging[J].Invest Radiol,2011,46(4):277-283.
    [22]YAMADA A,HARA T,LI F,et al.Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging[J].Radiology,2011,260(3):727-733.
    [23]TAJIMA T,TAKAO H,AKAI H,et al.Relationship between liver function and liver signal intensity in hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging[J].J Comput Assist Tomogr,2010,34(3):362-366.
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