Current research status of animal models for acute-on-chronic liver failure

Wei LIU; Lang BAI

doi:10.12449/JCH240131

Volume 40 Issue 1

Jan. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(1): 187-192

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Current research status of animal models for acute-on-chronic liver failure

DOI: 10.12449/JCH240131

Wei LIU,
Lang BAI^{,
,}

Center of Infectious Diseases，West China Hospital，Sichuan University，Chengdu 610041，China

Research funding:

The 1·3·5 Project for Disciplines of Excellence of West China Hospital of Sichuan University (ZYJC21014)

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Corresponding author: Bai Lang， pangbailiang@163.com （ORCID： 0000-0001-5042-4336）
Received Date: 2023-05-19
Accepted Date: 2023-06-19
Published Date: 2024-01-23

Abstract

Abstract

Acute-on-chronic liver failure has complex conditions， rapid progression， and a high mortality rate， and further studies are still needed to clarify its pathogenesis and etiology. The establishment of animal models for acute-on-chronic liver failure can not only provide a good basis for exploring the pathogenesis of acute-on-chronic liver failure， but also provide an experimental basis for clinical treatment. Through a literature review， this article summarizes the methods commonly used to establish the animal models of acute-on-chronic liver failure， including carbon tetrachloride combined with LPS/GaIN， thioacetamide combined with LPS， serum albumin， and bile duct ligation. This article analyzes the characteristics of various animal models， so as to provide documentary and experimental bases for further exploration of more ideal animal models.
- Liver Diseases,
- Acute-On-Chronic Liver Failure,
- Models， Animal

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References(34)

References

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Current research status of animal models for acute-on-chronic liver failure

DOI: 10.12449/JCH240131

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Current research status of animal models for acute-on-chronic liver failure

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