2024 No. 1

Vol.40 No.1 (279 in total) Jan. 2024

Theme Issue: New Progress in the Diagnosis and Treatment of Hepatic Vascular Diseases

Executive Chief Editor: ZHUGE Yuzheng

Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School

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Editorial

Screening for the etiology of non-cirrhotic splanchnic vein thrombosis should be taken seriously in clinical practice

Yuzheng ZHUGE

2024, 40(1): 10-12. DOI: 10.12449/JCH240101

Abstract(514)

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Abstract:
Non-cirrhotic splanchnic vein thrombosis （NC-SVT） mainly includes portal vein thrombosis， superior mesenteric vein thrombosis， splenic vein thrombosis， and hepatic vein thrombosis （Budd-Chiari syndrome）， and its prevalence rate is increasing with the increase in the incidence rates of related underl...

Expert Forum

Research advances in the diagnosis and treatment of hepatic vein occlusion-type Budd-Chiari syndrome

Xu GUO, Hao WU

2024, 40(1): 13-18. DOI: 10.12449/JCH240102

Abstract(863)

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Abstract:
Budd-Chiari syndrome is a rare liver vascular disease and can be classified into hepatic vein occlusion type， inferior vena cava occlusion type， and mixed type according to the location of hepatic outflow tract obstruction. This article reviews the hepatic vein occlusion type from the aspects of epi...

Research advances in porto-sinusoidal vascular disease

Fuliang HE, Jidong JIA

2024, 40(1): 19-23. DOI: 10.12449/JCH240103

Abstract(1599)

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Abstract:
Porto-sinusoidal vascular disease （PSVD） is a new disease nomenclature proposed in recent years， which is an important supplement to idiopathic non-cirrhotic portal hypertension. PSVD includes the patients with specific pathological conditions， but without portal hypertension symptoms， and the patie...

Research advances in hepatic sinusoidal obstruction syndrome

Ming ZHANG

2024, 40(1): 24-28. DOI: 10.12449/JCH240104

Abstract(1052)

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Abstract:
Hepatic sinusoidal obstruction syndrome （HSOS）， also known as hepatic veno-occlusive disease， is hepatic vascular disease of hepatic sinusoidal obstruction and hepatic venular occlusion and fibrosis due to various causes. This article systematically elaborates on the research advances in HSOS from t...

Establishment and application of animal models for portal vein thrombosis

Zhuang LIU, Jihong CHEN, Xingshun QI, Xiangbo XU, Yuzheng ZHUGE

2024, 40(1): 29-32. DOI: 10.12449/JCH240105

Abstract(621)

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Abstract:
Portal vein thrombosis （PVT） refers to thromboembolism that occurs in the extrahepatic main portal vein and/or intrahepatic portal vein branches. PVT is the result of the combined effect of multiple factors， but its pathogenesis remains unclear. Animal models are an important method for exploring th...

Guideline

An excerpt of AASLD practice guidance on risk stratification and management of portal hypertension and varices in cirrhosis （2023）

Bohan LUO, Guohong HAN

2024, 40(1): 33-36. DOI: 10.12449/JCH240106

Abstract(1150)

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Abstract:
This Practice Guidance intends to coalesce best practice recommendations for the identification of portal hypertension （PH）， for prevention of initial hepatic decompensation， for the management of acute variceal hemorrhage （AVH）， and for reduction of the risk of recurrent variceal hemorrhage in chro...

An excerpt of Asia-Pacific Association for the Study of the Liver guidelines on management of ascites in liver disease （2023）

Junyuan ZHU, Xiao LIU, Yawei CHENG, Qingchen WANG, Xiaochen LIU, Yuhua ZHU, Chunqing ZHANG

2024, 40(1): 37-41. DOI: 10.12449/JCH240107

Abstract(1083)

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Abstract:
Asia-Pacific Association for the Study of the Liver published the guidelines on management of ascites in liver disease in May 2023， which introduces the diagnosis， differential diagnosis， and treatment of ascites， hyponatremia， hepatic hydrothorax， and hepatorenal syndrome in patients with liver cir...

An excerpt of an international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease （2023）

Danqin SUN, Jiaqi SHEN, Minghua ZHENG

2024, 40(1): 42-45. DOI: 10.12449/JCH240108

Abstract(1093)

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Abstract:
In 2020， an international expert panel proposed to replace nonalcoholic fatty liver disease with metabolic associated fatty liver disease （MAFLD）. Recent studies have shown that there is a higher risk of chronic kidney disease （CKD） in the MAFLD population and that MAFLD is an independent risk facto...

Viral Hepatitis

Application value of liver/spleen CT value， controlled attenuation parameter， and magnetic resonance imaging-proton density fat fraction in chronic hepatitis B patients with hepatic steatosis

Jingnan LU, Yansong LI, Ya WEN, Xionghui WANG, Zhaoyu QU, Jianlong LI, Wei ZHANG

2024, 40(1): 46-51. DOI: 10.12449/JCH240109

Abstract(750)

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Abstract:
Objective To investigate the application value of liver/spleen CT value （CT_L/S）， controlled attenuation parameter （CAP）， and magnetic resonance imaging-proton density fat fraction （MRI-PDFF） in chronic hepatitis B （CHB） patients with hepatic steatosis. Methods A retrospective analysis was performed ...

Dynamic change and significance of Mindin protein in chronic hepatitis B treated with PEG-IFNα-2b

Yikai WANG, Fengping WU, Chenrui LIU, Miao HAO, Shasha LYU, Miaomiao ZHANG, Shuangsuo DANG, Xin ZHANG

2024, 40(1): 52-57. DOI: 10.12449/JCH240110

Abstract(415)

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Abstract:
Objective To investigate the change and potential role of Mindin protein in the treatment of chronic hepatitis B （CHB） with PEG-IFNα-2b. Methods A total of 29 CHB patients who received the treatment with PEG-IFNα-2b in The Second Affiliated Hospital of Xi’an Jiaotong University from January 2018 to ...

Correlation between serum HBV RNA and duration of treatment with nucleos（t）ide analogues in patients with chronic hepatitis B

Xueli FAN, Aiqin ZHAN, Yi AN, Liyan TIAN

2024, 40(1): 58-63. DOI: 10.12449/JCH240111

Abstract(508)

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Abstract:
‍Objective To investigate the serum level of HBV RNA in untreated or treatment-experienced patients with chronic hepatitis B （CHB） and the correlation between serum HBV RNA level and the duration of antiviral therapy with nucleos（t）ide analogues （NAs）. Methods A total of 300 patients with CHB who at...

Fatty Liver Disease

Role of salidroside in a mouse model of non-alcoholic fatty liver disease： A study based on nicotinamide phosphoribosyltransferase

Rongjun LI, Chunxia XU, Ting ZHANG, Zhihong ZHANG, Lyu WANG

2024, 40(1): 64-69. DOI: 10.12449/JCH240112

Abstract(472)

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Abstract:
Objective To investigate the protective effect of salidroside against nonalcoholic fatty liver disease （NAFLD） and its mechanism of action. Methods A total of 24 male KM mice were randomly divided into normal group， HFD group， HFD+blank control group， and HFD+salidroside group， with 6 mice in each g...

Liver Fibrosis and Liver Cirrhosis

Changes in the total volume and contour density of oval cells in hepatic lobules of rats with carbon tetrachloride-induced hepatic fibrosis： A stereological study

Chuanlin WANG, Quanming LIU, Xia YANG, Zhengwei YANG, Xiaoping MEI, Bin PENG

2024, 40(1): 70-75. DOI: 10.12449/JCH240113

Abstract(517)

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Abstract:
Objective To quantitatively investigate the changes in the total volume and contour density of hepatic oval cells （HOC） in hepatic lobules of rats with carbon tetrachloride （CCl₄）-induced hepatic fibrosis. Methods A total of 11 healthy male Sprague-Dawley rats were randomly divided into control grou...

Role and mechanism of action of phytoestrogen biochanin A in improving liver fibrosis in ovariectomized mice

Chaorong TAN, Xiaopiao LI, Junyan RAN, Ying XIONG, Shanggao LIAO, Jinjuan ZHANG, Xun HE

2024, 40(1): 76-82. DOI: 10.12449/JCH240114

Abstract(400)

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Abstract:
Objective To investigate the effect of phytoestrogen biochanin A （BCA） on liver fibrosis induced by CCl₄ in female mice with bilateral oophorectomy （ovariectomized） and its mechanism. Methods A total of 50 ovariectomized Kunming mice were selected and given intraperitoneal injection of CCl₄ to estab...

Characteristics of the composition of intestinal flora in cirrhotic patients with malnutrition

Jiongjiong BI, Yingjie MA

2024, 40(1): 83-88. DOI: 10.12449/JCH240115

Abstract(518)

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Abstract:
Objective To investigate the characteristics of the composition of intestinal flora and the serum level of endotoxin in cirrhotic patients with malnutrition， and to provide new diagnosis and treatment ideas for improving the nutritional status of patients with liver cirrhosis. Methods A total of 58 ...

Efficacy of percutaneous transhepatic variceal embolization alone or in combination with partial splenic embolization in treatment of portal hypertensive hemorrhage in liver cirrhosis： A Meta-analysis

Junyuan ZHU, Yifu XIA, Yanmei DU, Chunqing ZHANG

2024, 40(1): 89-95. DOI: 10.12449/JCH240116

Abstract(621)

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Abstract:
Objective To investigate the efficacy of percutaneous transhepatic variceal embolization （PTVE） alone or in combination with partial splenic embolization （PSE） in the treatment of portal hypertensive hemorrhage in liver cirrhosis through a meta-analysis. Methods This study was conducted according to...

Therapeutic effect of transplantation of bone marrow mesenchymal stem cells co-cultured with bone marrow M2 macrophages on a rat model of liver cirrhosis

Xinrui ZHENG, Yannan XU, Danyang WANG, Feifei XING, Mengyao ZONG, Shihao ZHANG, Junyi ZHAN, Wei LIU, Gaofeng CHEN, Jiamei CHEN, Ping LIU, Yongping MU

2024, 40(1): 96-103. DOI: 10.12449/JCH240117

Abstract(682)

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Abstract:
Objective To investigate the effect of transplantation of bone marrow mesenchymal stem cells （BMSCs） co-cultured with bone marrow-derived M2 macrophages （M2-BMDMs）， named as BMSC^M2， on a rat model of liver cirrhosis induced by carbon tetrachloride （CCl₄）/2-acetaminofluorene （2-AAF）. Methods Rat BMDM...

Other Liver Disease

Abnormal liver biochemical parameters in pregnancy during the epidemic of coronavirus disease 2019

Binbin LIU, Wen GAO, Xiaoyuan XU, Jianxiang LIU

2024, 40(1): 104-109. DOI: 10.12449/JCH240118

Abstract(417)

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Abstract:
Objective To investigate the differences in abnormal liver biochemical parameters in pregnant patients during the epidemic or non-epidemic period of coronavirus disease 2019 （COVID-19）. Methods A retrospective analysis was performed for 539 pregnant women who were discharged from Department of Obste...

Clinical effect of double plasma molecular adsorption system in treatment of patients with chronic liver failure in high-altitude areas

Bowen WANG, Mengjia PENG, Liheng JIANG, Fei FANG, Yuliang WANG, Yuandi SHEN

2024, 40(1): 110-115. DOI: 10.12449/JCH20240119

Abstract(380)

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Abstract:
Objective To investigate the differences in clinical features and mortality rate between native patients with chronic liver failure （CHF） and migrated patients with CHF after treatment with double plasma molecular adsorption system （DPMAS） in high-altitude areas. Methods A total of 63 patients with ...

Clinical features of patients with hepatolenticular degeneration aged above 35 years

Hongyun WO, Chengwei KANG, Lei ZHAN, Xiaobing PU

2024, 40(1): 116-120. DOI: 10.12449/JCH240120

Abstract(466)

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Abstract:
Objective To investigate the clinical features of patients with hepatolenticular degeneration （HLD） aged above 35 years. Methods A retrospective analysis was performed for the clinical data of the patients with HLD， aged above 35 years， who attended West China School of Public Health， Sichuan Univer...

Menaquinone-4 exerts a protective effect against carbon tetrachloride-induced acute liver injury in mice by alleviating ferroptosis

Lu YE, Fan ZHAO, Qianqian HUANG, Jiayi ZHANG, Jianqing WANG

2024, 40(1): 121-128. DOI: 10.12449/JCH240121

Abstract(359)

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Abstract:
Objective To investigate whether menaquinone-4 （MK-4） can exert a protective effect against carbon tetrachloride （CCl₄）-induced acute liver injury （ALI） in mice by alleviating ferroptosis. Methods After adaptive feeding， adult male ICR mice， aged 8 weeks， were divided into Control group， MK-4 group，...

Pancreatic Disease

Efficacy and safety of omental wrapping technique for pancreaticojejunal anastomosis in preventing complications after pancreaticoduodenectomy： A Meta-analysis

Yabo SHI, Yang LI, Huabing LIU, Zhicong WANG, Changwen HUANG

2024, 40(1): 129-137. DOI: 10.12449/JCH240122

Abstract(466)

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Abstract:
Objective To systematically evaluate the efficacy and safety of omental wrapping technique for pancreaticojejunal anastomosis in preventing complications after pancreaticoduodenectomy. Methods This study was conducted according to the PRISMA guideline. English and Chinese databases including CNKI， W...

Value of a nomogram model in early recurrence of pancreatic ductal adenocarcinoma after laparoscopic pancreaticoduodenectomy

Shun LIU, Cheng XIE, Yahui LIU

2024, 40(1): 138-146. DOI: 10.12449/JCH240123

Abstract(443)

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Abstract:
Objective To investigate the risk factors for early tumor recurrence after laparoscopic pancreaticoduodenectomy （LPD） in patients with pancreatic ductal adenocarcinoma （PDAC）， and to establish a predictive model. Methods A retrospective analysis was performed for the clinical data of 240 PDAC patien...

Review

The mechanism of action of mitochondrial dysfunction in the development of non-alcoholic fatty liver disease

Bingqing YANG, Jingya YIN, Qi WANG

2024, 40(1): 147-150. DOI: 10.12449/JCH240124

Abstract(902)

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Abstract:
Nonalcoholic fatty liver disease （NAFLD） has gradually become the main reason affecting human liver health， and many factors are involved in the development and progression of NAFLD. Mitochondria， as the “energy factory” of cells， plays an important role in maintaining normal physiological functions...

Research advances in primary biliary cholangitis with dyslipidemia

Shiyu YUAN, Huanhuan YANG, Yingmei TANG

2024, 40(1): 151-156. DOI: 10.12449/JCH240125

Abstract(498)

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Abstract:
Primary biliary cholangitis （PBC） is an autoimmune liver disease characterized by progressive and non-purulent inflammation of small- and medium-sized bile ducts in the liver. Recent studies have shown that abnormal lipid metabolism is relatively common in patients with PBC， and 76% of PBC patients ...

The role and impact of macrophages in the pathogenesis of primary biliary cholangitis

Di MA, Wenlin TAI

2024, 40(1): 157-160. DOI: 10.12449/JCH240126

Abstract(387)

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Abstract:
Primary biliary cholangitis （PBC） is a chronic autoimmune disease of cholestasis in which immune factors lead to progressive small bile duct destruction， cholestasis， and eventually liver fibrosis， liver cirrhosis， and even liver failure. Macrophages， as a group with functional heterogeneity， play d...

Research advances in traditional Chinese medicine regulation of programmed cell death in intervening against hepatic fibrosis

Liangjiang HUANG, Dewen MAO, Rongzhen ZHANG, Guochu HUANG, Han WANG, Weibin QIN, Chun YAO

2024, 40(1): 161-168. DOI: 10.12449/JCH240127

Abstract(559)

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Abstract:
Hepatic fibrosis （HF） is a pathological process of abnormal repair of liver tissue structure caused by chronic liver injury， and its pathogenesis has not been fully clarified. Related studies have shown that programmed cell death may be associated with the onset of HF， and traditional Chinese medici...

Portal vein thrombosis in liver cirrhosis： Risk factors and protection strategies

Wenjuan FENG, Ning ZHOU, Yulu WANG, Zhaoqin BAI

2024, 40(1): 169-174. DOI: 10.12449/JCH240128

Abstract(509)

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Abstract:
Portal vein thrombosis （PVT） is one of the common complications during the natural course of liver cirrhosis and has an important influence on the progression of liver cirrhosis. This article mainly summarizes the research advances in the risk factors for PVT. There are many risk factors for PVT， an...

Current status and prospects of transarterial chemoembolization and its combined regimens in the treatment of hepatocellular carcinoma

Zexin HU, Jintao HUANG, Binyan ZHONG, Jian SHEN, Xiaoli ZHU

2024, 40(1): 175-180. DOI: 10.12449/JCH240129

Abstract(631)

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Abstract:
Transarterial chemoembolization （TACE） is currently the primary treatment method for advanced liver cancer. This article elaborates on the current status of application of TACE in hepatocellular carcinoma from the aspects of existing techniques， patient selection， and efficacy assessment and summari...

Role of exosomes in intrahepatic cholangiocarcinoma

Jinyuan TANG, Chenfenglin YANG, Dongle LIANG, Yuhao LUO

2024, 40(1): 181-186. DOI: 10.12449/JCH240130

Abstract(404)

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Abstract:
Intrahepatic cholangiocarcinoma （ICC） is a special type of liver cancer with atypical clinical symptoms in the early stage， and most patients are already in the advanced stage at the time of initial diagnosis. Due to a lack of effective molecular markers and treatment options， ICC patients tend to h...

Current research status of animal models for acute-on-chronic liver failure

Wei LIU, Lang BAI

2024, 40(1): 187-192. DOI: 10.12449/JCH240131

Abstract(747)

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Acute-on-chronic liver failure has complex conditions， rapid progression， and a high mortality rate， and further studies are still needed to clarify its pathogenesis and etiology. The establishment of animal models for acute-on-chronic liver failure can not only provide a good basis for exploring th...

Research advances in the immunomodulatory mechanism of galectin-9 and its role in liver diseases

Jun LING, Bing ZHU, Weiwei CHEN, Zhuoran WANG, Limei YU, Shaoli YOU

2024, 40(1): 193-198. DOI: 10.12449/JCH240132

Abstract(792)

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Abstract:
Galectin-9 （Gal-9） is a member of the galectin family that can specifically recognize and bind to galactosides. Recent studies have shown that Gal-9 is highly expressed in the liver and can help to maintain intrahepatic immune homeostasis and perform biological functions in various liver diseases. T...

Role of apical sodium-dependent bile acid transporter in hepatobiliary diseases

Xiaoxuan XIE, Lina DU, Ziyun GUO, Yan YANG

2024, 40(1): 199-203. DOI: 10.12449/JCH240133

Abstract(826)

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Abstract:
Apical sodium-dependent bile acid transporter （ASBT） is a key transporter responsible for intestinal reabsorption of bile acid and plays an important role in maintaining bile acid and cholesterol homeostasis， and its expression is regulated by various factors including transcription factors， nuclear...

The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

Jiachen FENG, Ping ZHANG

2024, 40(1): 204-207. DOI: 10.12449/JCH240134

Abstract(582)

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Abstract:
Compared with acute pancreatitis caused by other factors， hyperlipidemic acute pancreatitis often has a higher rate of severe conditions， greater difficulties in predicting prognosis， and a more complex and unclear pathogenesis. At present， the pathogenesis of hyperlipidemic acute pancreatitis may b...