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Volume 40 Issue 1
Jan.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(1): 199-203

Role of apical sodium-dependent bile acid transporter in hepatobiliary diseases

DOI: 10.12449/JCH240133

  • Department of Traditional Chinese Medicine，National Center for Children’s Health，Beijing Children’s Hospital，Capital Medical University，Beijing 100045，China

Research funding:

National Natural Science Foundation of China (82205184);

Bejing Municipal Administration of Hospital Incubating Program (PZ2022027)

More Information
  • Corresponding author: YANG yan， yy2303@sina.com （ORCID： 0000-0003-1070-9614）
  • Received Date: 2023-03-29
  • Accepted Date: 2023-05-06
  • Published Date: 2024-01-23
    Abstract
  • Apical sodium-dependent bile acid transporter （ASBT） is a key transporter responsible for intestinal reabsorption of bile acid and plays an important role in maintaining bile acid and cholesterol homeostasis， and its expression is regulated by various factors including transcription factors， nuclear receptors， and intestinal microflora. The abnormal expression and function of ASBT can lead to disorders in the metabolism of bile acid and cholesterol， causing a variety of hepatobiliary diseases. At present， ASBT has attracted wide attention as a therapeutic target. This article elaborates on the biological characteristics and expression regulation mechanism of ASBT and reviews the role of ASBT in hepatobiliary diseases， in order to provide a new direction for the treatment of related diseases.

     

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