Association of polymorphisms of the acetyl-coA acetyltransferase 1 gene and the melatonin receptor 1B gene with the susceptibility to nonalcoholic fatty liver disease

Lei MA; Xinxin HU; Bo ZHAO; Qiang WAN; Lin ZHOU; Zhenzhen ZHAO; Yongning XIN

doi:10.12449/JCH240410

Volume 40 Issue 4

Apr. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(4): 700-705

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Association of polymorphisms of the acetyl-coA acetyltransferase 1 gene and the melatonin receptor 1B gene with the susceptibility to nonalcoholic fatty liver disease

DOI: 10.12449/JCH240410

1.
Department of Infectious Diseases，Qingdao Chengyang District People’s Hospital，Qingdao，Shandong 266109，China
2a.
Clinical Research Center，Qingdao Municipal Hospital，Qingdao，Shandong 266071，China
2b.
Department of Infectious Diseases，Qingdao Municipal Hospital，Qingdao，Shandong 266071，China

Research funding:

National Natural Science Foundation of China (32171277)

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Corresponding author: XIN Yongning， xinyongning@163.com （ORCID： 0000-0002-3692-7655）
Received Date: 2023-08-05
Accepted Date: 2023-09-04
Published Date: 2024-04-25

Abstract

Abstract

Objective To investigate the association of the polymorphisms of the acetyl-CoA acetyltransferase 1 （ACAT1） gene and the melatonin receptor 1B （MTNR1B） gene with the susceptibility to nonalcoholic fatty liver disease （NAFLD）. Methods A total of 164 healthy controls and 228 NAFLD patients were enrolled in this study. PCR and sequencing methods were used to determine the genotypes of the polymorphisms of the ACAT1 gene at the rs1044925 and rs1157651 loci and the MTNR1B gene at the rs10830963 locus， and fasting venous blood samples were collected for biochemical analysis. The t-test was used for comparison of normally distributed continuous data between groups， and the non-parametric Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups； the chi-square test was used for comparison of categorical data between groups. Results There were no significant differences between the NAFLD group and the healthy control group in the genotype distribution of the ACAT1 gene at the rs1044925 and rs1157651 loci and the MTNR1B gene at the rs10830963 locus （all P>0.05）. The carriers of AA genotype at the rs1044925 locus of the ACAT1 gene had a significantly higher level of low-density lipoprotein than the carriers of C allele （Z=-2.08， P=0.04）， and the carriers of G allele at the rs10830963 locus of the MTNR1B gene had a significantly higher level of fasting blood glucose than the carriers of CC genotype （Z=-3.01， P<0.01）. Conclusion The polymorphisms of the ACAT1 gene at the rs1044925 and rs1157651 loci and the MTNR1B gene at the rs10830963 locus were not associated with the susceptibility to NAFLD. The rs1044925 locus of the ACAT1 gene and the rs10830963 locus of the MTNR1B gene are associated with the levels of low-density lipoprotein and fasting blood glucose， respectively.
- Non-alcoholic Fatty Liver Disease,
- Acetyl-CoA C-Acetyltransferase,
- Receptors， Melatonin

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References

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Association of polymorphisms of the acetyl-coA acetyltransferase 1 gene and the melatonin receptor 1B gene with the susceptibility to nonalcoholic fatty liver disease

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Association of polymorphisms of the acetyl-coA acetyltransferase 1 gene and the melatonin receptor 1B gene with the susceptibility to nonalcoholic fatty liver disease

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