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Vol.40 No.4 (282 in total) Apr. 2024
Theme Issue: Elimination of Hepatitis C Virus Infectionnction
Executive Chief Editor: CHEN Hongsong, RAO Huiying  
Peking University People’s Hospital
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Editorial
Current status of hepatitis C virus infection and progress in its elimination in China
Haiying ZHANG, Huiying RAO, Hongsong CHEN
2024, 40(4): 649-653. DOI: 10.12449/JCH240401
Abstract(883) HTML (501) PDF (689KB)(284) Cited By (1)
Abstract:
Hepatitis C virus （HCV） can develop into liver cirrhosis or hepatocellular carcinoma， imposing a heavy burden on the patient’s family and the society. Hepatitis C is one of the major public threats for humans， and eliminating hepatitis C is a common goal of all humans. Direct-acting antiviral agents...
Expert Forum
Management of hepatitis C in children and pregnant women
Yishan LIU, Lanting ZHANG, Yunyu ZHAO, Fanpu JI, Qinglei ZENG
2024, 40(4): 654-658. DOI: 10.12449/JCH240402
Abstract(541) HTML (139) PDF (643KB)(134) Cited By (1)
Abstract:
Hepatitis C virus infection is a global public health issue， and the emergence of direct-acting antiviral agents has brought revolutionary breakthroughs in the treatment of hepatitis C patients. Although direct-acting antiviral agents have a marked therapeutic effect in adult patients， there are sti...
Micro-elimination of hepatitis C virus infection in the hemodialysis population
Liangying GAN, Li ZUO
2024, 40(4): 659-664. DOI: 10.12449/JCH240403
Abstract(588) HTML (197) PDF (645KB)(100)
Abstract:
The hemodialysis population is increasing year by year in China. Due to the specific nature of hemodialysis treatment， the prevalence and incidence rates of hepatitis C virus （HCV） infection in hemodialysis patients are much higher than the general population. In order to achieve the WHO’s initiativ...
Hepatitis C virus infection and organ transplantation
Li ZHANG, Peng HU
2024, 40(4): 665-671. DOI: 10.12449/JCH240404
Abstract(371) HTML (177) PDF (710KB)(55)
Abstract:
In recent years， rapid progress has been made in strategies for the prevention and treatment of hepatitis C virus （HCV） in organ transplant candidates and recipients， and although HCV infections no longer threaten transplantation outcomes in liver or non-hepatic solid organ transplantation， they rem...
Advances in laboratory testing methods and strategies for hepatitis C virus infection
Yu WANG, Wenge XING, Zhongfu LIU, Cong JIN
2024, 40(4): 672-678. DOI: 10.12449/JCH240405
Abstract(621) HTML (335) PDF (928KB)(161) Cited By (2)
Abstract:
Laboratory testing for hepatitis C virus （HCV） infection provides an important basis for the identification and diagnosis of patients with HCV infection. With the continuous development of HCV testing in recent years， the performance of reagents has been significantly improved， and new testing servi...
Guideline
An excerpt of American Association for the Study of Liver Diseases practice guidance on acute-on-chronic liver failure and the management of critically ill patients with cirrhosis in 2023
Haofeng XIONG, Liying. SUN
2024, 40(4): 679-681. DOI: 10.12449/JCH240406
Abstract(844) HTML (268) PDF (488KB)(233)
Abstract:
The expert panel of American Association for the Study of Liver Diseases published Practice guidance on acute-on-chronic liver failure and the management of critically ill patients with cirrhosis on November 9， 2023 in Hepatology. This practice guidance elaborates on the definition of acute-on-chron...
Recommendations from Annals of Surgical Oncology： Clinical guidelines for extrahepatic cholangiocarcinoma and gallbladder carcinoma
Wei GUO, Xin LI, Mingda WANG, Tian YANG
2024, 40(4): 682-687. DOI: 10.12449/JCH240407
Abstract(1420) HTML (596) PDF (997KB)(351)
Abstract:
Biliary tract carcinoma （BTC） is a type of gastrointestinal tumor with a low incidence rate and a strong invasive ability， mainly including intrahepatic cholangiocarcinoma （ICC）， extrahepatic cholangiocarcinoma （ECC）， and gallbladder carcinoma （GC）， often accompanied by local progression or distant ...
Fatty Liver Disease
Association between urinary thallium and nonalcoholic fatty liver disease
Yajie LIU, Ruilin WANG, Zihan LIANG, Jiahui LI, Yujie HAO
2024, 40(4): 688-693. DOI: 10.12449/JCH240408
Abstract(410) HTML (119) PDF (791KB)(66) Cited By (1)
Abstract:
Objective To investigate the association between urinary thallium （TL） and nonalcoholic fatty liver disease （NAFLD）. Methods Related data were collected from the registered participants aged ≥18 years in National Health and Nutrition Examination Survey from 2017 to 2020， with th exclusion of the ind...
Value of Fetuin-A， Fetuin-B， and insulin resistance index in predicting nonalcoholic fatty liver disease
Sulian YANG, Rongjie SHI, Lihua LI
2024, 40(4): 694-699. DOI: 10.12449/JCH240409
Abstract(470) HTML (147) PDF (724KB)(53) Cited By (1)
Abstract:
Objective To investigate the value of serum Fetuin-A and Fetuin-B combined with Homeostasis Model Assessment of Insulin Resistance （HOMA-IR） in predicting nonalcoholic fatty liver disease （NAFLD）. Methods A total of 120 patients with NAFLD who attended Department of Gastroenterology， The First Affil...
Association of polymorphisms of the acetyl-coA acetyltransferase 1 gene and the melatonin receptor 1B gene with the susceptibility to nonalcoholic fatty liver disease
Lei MA, Xinxin HU, Bo ZHAO, Qiang WAN, Lin ZHOU, Zhenzhen ZHAO, Yongning XIN
2024, 40(4): 700-705. DOI: 10.12449/JCH240410
Abstract(504) HTML (190) PDF (644KB)(36) Cited By (1)
Abstract:
Objective To investigate the association of the polymorphisms of the acetyl-CoA acetyltransferase 1 （ACAT1） gene and the melatonin receptor 1B （MTNR1B） gene with the susceptibility to nonalcoholic fatty liver disease （NAFLD）. Methods A total of 164 healthy controls and 228 NAFLD patients were enroll...
Protective effect of Genistein against nonalcoholic fatty liver disease in ovariectomized mice and its mechanism
Xiangyu ZHU, Yong JIN
2024, 40(4): 706-711. DOI: 10.12449/JCH240411
Abstract(499) HTML (140) PDF (1690KB)(46)
Abstract:
Objective To investigate the protective effect of Genistein against nonalcoholic fatty liver disease （NAFLD） in ovariectomized （OVX） mice and its mechanism. Methods A total of 40 female C57BL/6 mice， aged 6 weeks， were used to establish an OVX mouse model， and then they were randomly divided into bl...
Therapeutic effect of Xiayuxue decoction on a mouse model of nonalcoholic fatty liver disease induced by high-fat diet and its mechanism
Linqi HOU, Zhiyi WANG, Xin ZHAO, Jie ZHANG, Wenting MA, Xuling LIU, Wei ZHANG, Le TAO, Cheng LIU, Liu WU
2024, 40(4): 712-719. DOI: 10.12449/JCH240412
Abstract(645) HTML (205) PDF (2184KB)(61) Cited By (3)
Abstract:
Objective To investigate the mechanism of action of Xiayuxue decoction in inhibiting nonalcoholic fatty liver disease （NAFLD） induced by high-fat diet in mice by regulating nucleotide binding oligomerization domain like receptor containing pyrin domain protein 6 （NLRP6）. Methods A total of 15 male C...
Liver Fibrosis and Liver Cirrhosis
Value of MRI biliary score and liver/muscle ratio in evaluating the pathological grade of liver fibrosis
Lu HUANG, Lijian LU
2024, 40(4): 720-725. DOI: 10.12449/JCH240413
Abstract(502) HTML (190) PDF (1168KB)(37)
Abstract:
Objective To investigate the value of biliary score and hepatic signal intensity-to-muscle signal intensity ratio （HMR） obtained by multiphase contrast-enhanced MRI scan using Gd-EOB-DTPA in evaluating the pathological grade of liver fibrosis. Methods A retrospective analysis was performed for the M...
Changing trend of the disease burden of liver cirrhosis in China from 1990 to 2019
Shanshan LIU, Xiaohui YU, Jianwei CAI
2024, 40(4): 726-733. DOI: 10.12449/JCH240414
Abstract(1565) HTML (477) PDF (1660KB)(313) Cited By (2)
Abstract:
Objective To investigate the prevalence of liver cirrhosis and the changing trend of the disease burden of liver cirrhosis in the Chinese population from 1990 to 2019， and to provide a data reference for formulating the prevention and treatment strategies for liver cirrhosis in China. Methods The Gl...
The preliminary therapeutic effect of endoscopic ultrasound-guided tissue adhesive injection with the assistance of metal clips in treatment of cirrhotic patients with gastric varices and gastric-renal shunt
Jiali MA, Zhenglin AI, Julong HU, Yu JIANG, Yuling ZHOU, Xiuxia LIANG, Hongshan WEI, Ping LI
2024, 40(4): 734-738. DOI: 10.12449/JCH240415
Abstract(483) HTML (148) PDF (1036KB)(31)
Abstract:
Objective To investigate the safety and efficacy of endoscopic ultrasound-guided tissue adhesive injection with the assistance of metal clips in the treatment of cirrhotic patients with gastric varices and gastric-renal shunt （GRS）. Methods The patients who attended Beijing Ditan Hospital， Capital M...
Efficacy of endoscopic ultrasound-guided coil placement combined with tissue adhesive injection in treatment of gastric varices with spontaneous shunt
Yafen TANG, Zhiyang JIANG, Dan LONG, Jinmin CHEN, Shan GAO
2024, 40(4): 739-744. DOI: 10.12449/JCH240416
Abstract(437) HTML (188) PDF (917KB)(38) Cited By (2)
Abstract:
Objective To investigate the efficacy， safety， and cost-effectiveness of endoscopic ultrasound （EUS）-guided coil placement combined with tissue adhesive injection in the treatment of gastric varices with spontaneous shunt. Methods A retrospective analysis was performed for the patients with acute ga...
Effect of Fuzheng Huayu prescription on hepatocyte extinction and regeneration in a mouse model of liver cirrhosis
Tingting ZHU, Jingshu QI, Yanan GUO, Hongliang LIU, Yanyan TAO, Zhimin ZHAO, Zhengxin LI, Chenghai LIU
2024, 40(4): 745-752. DOI: 10.12449/JCH240417
Abstract(529) HTML (214) PDF (4131KB)(38) Cited By (2)
Abstract:
Objective To investigate the effect of Fuzheng Huayu prescription on hepatocyte extinction and regeneration in fibrotic liver and its mechanism of action in promoting hepatocyte regeneration. Methods Mice were given intraperitoneal injection of CCl4 for 6 weeks to establish a model of liver cirrhosi...
Liver Neoplasm
Influence of triglyceride/high-density lipoprotein cholesterol ratio on the onset of primary liver cancer
Jianguo JIA, Xiangming MA, Fei TIAN, Yali ZHANG, Jiaying DAI, Saifang LUO, Liying CAO
2024, 40(4): 753-759. DOI: 10.12449/JCH240418
Abstract(1007) HTML (563) PDF (802KB)(61)
Abstract:
Objective To investigate the influence of triglyceride （TG）/high-density lipoprotein cholesterol （HDL-C） ratio on the onset of primary liver cancer. Methods A prospective cohort study was conducted. Physical examination data were collected from 99 750 cases of on-the-job and retired employees of Kai...
Other Liver Disease
Clinical features and early warning indicators of patients with acute-on-chronic liver failure and bacterial infection
Zhanhu BI, Linxu WANG, Haifeng HU, Hong DU, Yidi DING, Xiaofei YANG, Jiayi ZHAN, Fei HU, Denghui YU, Hongkai XU, Jianqi LIAN
2024, 40(4): 760-766. DOI: 10.12449/JCH240419
Abstract(456) HTML (146) PDF (667KB)(69) Cited By (1)
Abstract:
Objective To investigate the clinical features of patients with acute-on-chronic liver failure （ACLF） and bacterial infection and early warning indicators associated with multidrug-resistant infections. Methods A retrospective analysis was performed for 130 patients with ACLF and bacterial infection...
Biliary Disease
Clinical diagnosis， treatment， and prognosis of gallbladder sarcomatoid carcinoma： An analysis of 16 cases
Yashu ZHOU, Yihui MA, Jiaxin PEI, Yuanyuan MENG, Peng GUO, Xiyue LIANG, Taiying LU
2024, 40(4): 767-772. DOI: 10.12449/JCH240420
Abstract(432) HTML (124) PDF (1085KB)(47)
Abstract:
Objective To investigate the clinicopathological features， diagnosis and treatment methods， and prognosis of gallbladder sarcomatoid carcinoma （GBSC）. Methods A retrospective analysis was performed for the clinical data of 16 patients with GBSC who were admitted to The First Affiliated Hospital of Z...
Pancreatic Disease
Establishment of a risk prediction model for pancreatic fistula after pancreaticoduodenectomy： A study based on the 2016 edition of the definition and classification system of pancreatic fistula
Jun YU, Chaoyi REN, Wei CUI, Jingxiang SHI
2024, 40(4): 773-781. DOI: 10.12449/JCH240421
Abstract(476) HTML (189) PDF (797KB)(32) Cited By (2)
Abstract:
Objective To investigate the differences in the risk factors for postoperative pancreatic fistula （POPF） after pancreaticoduodenectomy （PD） between the 2005 and 2016 editions of the definition and classification standards for pancreatic fistula， and to establish a risk prediction model for pancreati...
Effect of echinacoside intervention on liver and pancreas injury in rats with acute pancreatitis and its mechanism
Minghe MA, Zhuoma DAWA, Chuanchuan LIU, Haining FAN
2024, 40(4): 782-790. DOI: 10.12449/JCH240422
Abstract(509) HTML (198) PDF (3277KB)(43) Cited By (1)
Abstract:
Objective To investigate the effect and mechanism of echinacoside （ECH） in improving liver injury in rats with acute pancreatitis by establishing a rat model of acute pancreatitis and liver injury. Methods A total of 24 Sprague-Dawley rats were randomly divided into blank group （Con group）， control ...
Case Report
Successful trans-blood liver transplantation after artificial liver support therapy in a patient with hepatic coma： A case report
Shuang SUN, Jinquan LIU, Shuai FENG, Shuxian WANG, Xiangmei XU, Deshu DAI, Jianhong WANG, Jinzhen CAI, Chuanshen XU
2024, 40(4): 791-793. DOI: 10.12449/JCH240423
Abstract(360) HTML (216) PDF (860KB)(47)
Abstract:
This article reports a patient with hepatic coma who underwent artificial liver support therapy and liver transplantation successfully， and the patient recovered well in the later stage after active treatment. This article also discusses the timing of liver transplantation.
Giant adenoma of the gallbladder misdiagnosed as gallbladder carcinoma： A case report
Yuehua WANG, Hua JIANG, Lianghong TENG, Huanli DUAN, Bixiao CUI, Dongmei WANG
2024, 40(4): 794-796. DOI: 10.12449/JCH240424
Abstract(526) HTML (289) PDF (1133KB)(37)
Abstract:
One patient with gallbladder mass had transient jaundice and was diagnosed with gallbladder carcinoma by abdominal ultrasonography， contrast-enhanced CT， MRCP， and PET-CT. Surgical exploration showed enlarged gallbladder and a mass in the neck of the gallbladder pressing against the hilum of the liv...
Review
Pathogenesis of hepatitis B-associated intrahepatic cholangiocarcinoma
Qiyu TIAN, Jian YU, Gang HUANG
2024, 40(4): 797-803. DOI: 10.12449/JCH240425
Abstract(616) HTML (175) PDF (977KB)(76)
Abstract:
Intrahepatic cholangiocarcinoma （ICC） is a type of primary liver cancer that accounts for about 10%‍ — ‍15% of the total cases， and its incidence and mortality rates tend to increase significantly around the world， especially in Asian countries. At present， radical liver resection is the only possib...
Mechanism of action of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease based on intestinal microecology
Xue YANG, Xu ZHANG, Jin XIAN, Qiwen TAN, Huijuan YU
2024, 40(4): 804-809. DOI: 10.12449/JCH240426
Abstract(649) HTML (189) PDF (794KB)(66) Cited By (2)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is a multisystem disease associated with obesity， insulin resistance， and dyslipidemia and has a complex pathogenesis. Studies have shown that gut microbiota dysbiosis is closely associated with the onset of NAFLD， and traditional Chinese medicine treatment c...
Mechanism of amino acid metabolism in nonalcoholic fatty liver disease
Hui ZHANG, Ming TAN, Shengtao CHENG, Juan CHEN
2024, 40(4): 810-815. DOI: 10.12449/JCH240427
Abstract(771) HTML (148) PDF (722KB)(88)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is one of the most prevalent chronic liver diseases in the world， affecting about one quarter of the global population， and it is estimated that NAFLD will become the main indication for liver transplantation by 2030. NAFLD can lead to significant abnormaliti...
Advances in the application of microspheres and nanoparticles in transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma
Chuyue ZHANG, Jianing SHI, Mingda WANG, Han WU, Lijun SHI, Tian YANG
2024, 40(4): 816-821. DOI: 10.12449/JCH240428
Abstract(438) HTML (287) PDF (690KB)(55)
Abstract:
In recent years， transcatheter arterial chemoembolization （TACE） has emerged as a common treatment modality for the treatment of hepatocellular carcinoma （HCC）. However， with the ongoing development of embolic agent techniques， the new advances in microspheres and nanoparticles have brought new hope...
Role of the Hedgehog signaling pathway in hepatocellular carcinoma and its tumor microenvironment
Xiaohua ZHANG, Ying FENG, Xianbo WANG
2024, 40(4): 822-827. DOI: 10.12449/JCH240429
Abstract(539) HTML (233) PDF (860KB)(60) Cited By (2)
Abstract:
The Hedgehog （Hh） signaling pathway plays an important role in the development and progression of hepatocellular carcinoma and its tumor microenvironment， and abnormal activation of Hh signal can accelerate the growth of tumor. The crosstalk between the Hh signaling pathway and TME is closely associ...
Advances in the treatment of acute hepatic porphyria
Jiajia LEI, Shuang LI, Baixue DONG, Jing YANG, Yi REN
2024, 40(4): 828-833. DOI: 10.12449/JCH240430
Abstract(604) HTML (146) PDF (976KB)(92)
Abstract:
Acute hepatic porphyria （AHP） is a rare disease with abnormal heme metabolism， and breakthroughs have been made in the treatment of this disease in recent years. In addition to conventional treatment methods， this article reviews new therapies for AHP that are in the stage of initial clinical applic...
Application and development of endoscopic techniques in the diagnosis and treatment of liver diseases
Jingyi LU, Ying QU, Lungen LU
2024, 40(4): 834-838. DOI: 10.12449/JCH240431
Abstract(524) HTML (161) PDF (641KB)(51)
Abstract:
Liver disease is one of the most important health problems around the world， and early diagnosis and timely intervention and treatment are the key to preventing liver-related morbidity and mortality rates. The development of endoscopic techniques has provided new diagnostic and intervention methods ...
Mechanism of action of macrophage efferocytosis in acute and chronic liver diseases and related targeted therapy
Huanhuan YANG, Shiyu YUAN, Yingmei TANG
2024, 40(4): 839-843. DOI: 10.12449/JCH240432
Abstract(642) HTML (499) PDF (630KB)(49)
Abstract:
Efferocytosis refers to the process by which apoptotic cells are engulfed and cleared by phagocytes， including professional phagocytes， such as macrophages and dendritic cells， and non-professional phagocytes， such as epithelial cells. Liver macrophages are the main cells with the function of effero...
Advances in the differential diagnosis of malignant bile duct stenosis
Chunyan MENG, Jing WANG, Bo WANG
2024, 40(4): 844-849. DOI: 10.12449/JCH240433
Abstract(416) HTML (356) PDF (779KB)(46) Cited By (2)
Abstract:
There are various etiologies for extrahepatic bile duct stenosis， and pharmacotherapy and endoscopic intervention can achieve a good clinical effect in benign stenosis. Early diagnosis and timely surgical treatment of malignant stenosis may prolong the survival time of patients. However， there are s...
Mechanism and prevention of liver failure complicated by acute pancreatitis
Xingyu LU, Jing YANG, Pan LI, Jianping PENG
2024, 40(4): 850-856. DOI: 10.12449/JCH240434
Abstract(511) HTML (327) PDF (1192KB)(76)
Abstract:
Liver failure often has rapid progression， multiple complications， and dangerous conditions. Acute pancreatitis is a common comorbidity during the progression of liver failure， and since acute pancreatitis has extremely similar clinical symptoms and signs to liver failure complicated by spontaneous ...
Acknowledgements
Current reviewers
2024, 40(4): 678-678. DOI: 10.12449/JCH2404.zhixie
Abstract(190) HTML (205) PDF (805KB)(18)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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Sponsor：Jilin University

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