Influence of triglyceride/high-density lipoprotein cholesterol ratio on the onset of primary liver cancer

Jianguo JIA; Xiangming MA; Fei TIAN; Yali ZHANG; Jiaying DAI; Saifang LUO; Liying CAO

doi:10.12449/JCH240418

Volume 40 Issue 4

Apr. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(4): 753-759

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Influence of triglyceride/high-density lipoprotein cholesterol ratio on the onset of primary liver cancer

DOI: 10.12449/JCH240418

Jianguo JIA^{1, 2},
Xiangming MA²,
Fei TIAN³,
Yali ZHANG²,
Jiaying DAI^{1, 2},
Saifang LUO^{1, 2},
Liying CAO^{2
,
,
,}

1.
Graduate School of North China University of Science and Technology，Tangshan，Hebei 063000，China
2.
Department of Hepatobiliary Surgery，Kailuan General Hospital，North China University of Science and Technology，Tangshan，Hebei 063000，China
3.
Department of Tumor Chemoradiotherapy，The Affiliated Hospital of North China University of Science and Technology，Tangshan，Hebei 063000，China

Research funding:

2023 Medical Science Research Project Plan of Hebei Province (20231865)

More Information

Corresponding author: CAO Liying， caoliying@kailuan.com.cn （ORCID： 0000-0003-3662-5961）
Received Date: 2023-07-15
Accepted Date: 2023-09-11
Published Date: 2024-04-25

Abstract

Abstract

Objective To investigate the influence of triglyceride （TG）/high-density lipoprotein cholesterol （HDL-C） ratio on the onset of primary liver cancer. Methods A prospective cohort study was conducted. Physical examination data were collected from 99 750 cases of on-the-job and retired employees of Kailuan Group who participated health examination from July 2006 to December 2007， and they were followed up till December 31， 2021 to observe the onset of primary liver cancer. A one-way analysis of variance was used for comparison of normally distributed continuous data between multiple groups， and the Kruskal-Wallis H test was used for comparison of continuous data with skewed distribution between multiple groups； the chi-square test was used for comparison of categorical data between groups. According to the tertiles of TG/HDL-C ratio， the subjects were divided into Q1， Q2， and Q3 groups， and the incidence density of primary liver cancer was calculated for each group. The Kaplan-Meier method was used to calculate the cumulative incidence rate of primary liver cancer in each group， and the log-rank test was used to compare the difference in cumulative incidence rate between groups. The Cox proportional hazards model was used to analyze the influence of TG/HDL-C ratio on the onset of primary liver cancer. Results There were significant differences between the three groups in age， proportion of male subjects， waist circumference， body mass index， fasting blood glucose， systolic pressure， diastolic pressure， triglyceride， total cholesterol， HDL-C， low-density lipoprotein cholesterol， alanine aminotransferase， high-sensitivity C-reactive protein， chronic liver diseases， hypertension， diabetes， the family history of malignant tumor， drinking， smoking， physical exercise， and educational level （P<0.05）. During the mean follow-up time of 14.06±2.71 years， there were 484 cases of new-onset liver cancer， among whom there were 446 male subjects and 38 female subjects. The incidence density of primary liver cancer was 0.39/1 000 person-years in the Q1 group， 0.35/1 000 person-years in the Q2 group， and 0.30/1 000 person-years in the Q3 group， and the cumulative incidence rates of primary liver cancer in the three groups were 6.03‰， 5.28‰， and 4.49‰， respectively， with a significant difference between the three groups based on the long-rank test （χ²=6.06， P=0.048）. After adjustment for the confounding factors considered， the Cox proportional hazards model showed that compared with the Q3 group， the Q1 group had a hazard ratio of 2.04 （95% confidence interval ［CI］： 1.61‍ ‍—‍ ‍2.58， P_{for trend}<0.05）， and the Q2 group had a hazard ratio of 1.53 （95%CI： 1.21‍ ‍—‍ ‍1.92， P_{for trend}<0.05）. Conclusion The reduction in TG/HDL-C ratio is associated with an increase in the rask of primary liver cancer， especially in people with chronic liver diseases.
- Liver Neoplasms,
- Triglycerides,
- Cholesterol， HDL,
- Cohort Studies

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References

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Influence of triglyceride/high-density lipoprotein cholesterol ratio on the onset of primary liver cancer

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