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CN 22-1108/R
Issue 11
Nov.  2013
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Article Navigation >  Journal of Clinical Hepatology  > 2013  >  29(11): 835-838

Effects of different anti- HIV therapies on progression of hepatitis C in HCV / HIV- coinfected patients

DOI: 10.3969/j.issn.1001-5256.2013.11.009

  • Department of Infectious Diseases, Shanghai Public Health Clinical Center

  • Received Date: 2012-11-28
  • Published Date: 2013-11-20
    Abstract
  • Objective To investigate the effect of protease inhibitors ( PIs) - or non- nucleoside reverse transcriptase inhibitors ( NNRTIs) - based therapy on the progression of hepatitis C in patients with hepatitis C virus ( HCV) / human immunodeficiency virus ( HIV) coinfection. Methods A total of 273 patients initially diagnosed with HCV / HIV coinfection were enrolled and divided into PIs group ( n = 135) and NNRTIs group ( n = 138) to receive PIs- based therapy and NNRTIs- based therapy, respectively, for one year. Laboratory indices, such as HCV RNA, aspartate aminotransferase ( AST) , alanine aminotransferase ( ALT) , total bilirubin ( TBil) , albumin ( Alb) , laminin ( LN) , cholyglycine ( CG) , type III procollagen ( PCIII) , type IV collagen ( CIV) , prothrombin activity ( PTA) , and cholinesterase ( CHE) , were quantified before and after treatment. The obtained data were analyzed using SPSS 11. 5 software; enumeration data were analyzed using the Kolmogorov- Smirnov test, and non- normal data were analyzed using the Mann- Whitney U test. Results After the end of treatment, PTA, CHE, TBil, Alb, ALT, AST, CG, and LN levels were significantly higher in NNRTIs group than in PIs [PTA: 77% ( 67%-109%) vs 68% ( 56%-91%) ; CHE: 6717. 00 U/L ( 5951. 00-7622. 00 U/L) vs 5862. 00 U/L ( 4392. 00- 8539. 25 U/L) ;TBil: 10. 95 μmol / L ( 8. 10- 14. 32 μmol / L) vs 8. 60 μmol / L ( 8. 00- 9. 50 μmol / L) ; Alb: 43. 90 mmol / L ( 39. 65- 48. 20 mmol / L) vs 38. 90 mmol / L ( 36. 00- 45. 00 mmol / L) ; ALT: 52. 50 U / L ( 30. 00- 93. 50 U / L) vs 36. 20 U / L ( 30. 30- 40. 40 U / L) ; AST: 49. 00U /L ( 33. 00- 80. 00 U / L) vs 31. 30 U / L ( 29. 70- 38. 70 U / L) ; CG: 16. 78 μg / ml ( 3. 26- 29. 32 μg / ml) vs 3. 26 μg / ml ( 1. 02-6. 88 μg / ml) ; LN: 34. 40 ng / ml ( 16. 71- 46. 54 ng / ml) vs 34. 05 ng / ml ( 33. 42- 64. 33 ng / ml) ; P < 0. 01 or P < 0. 05]. Conclusion NNRTIs- based therapy can accelerate the progression of hepatitis C in HCV / HIV- coinfected patients.

     

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