2013 No. 11

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Editorial

Hepatocellular adenoma: new understandings of molecular pathology and novel model of clinical diagnosis and therapy

Liu HaiPing, Cong WenMing

2013, 29(11): 801-804. DOI: 10.3969/j.issn.1001-5256.2013.11.001

Abstract(380)

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Abstract:
Hepatocellular adenoma ( HCA) is the most common benign hepatocellular tumor, and its causes remain unclear. In Western countries, HCA is usually seen in the women of reproductive age who have a history of long- term use of oral contraceptives ( OCs) . In the latest 2010 WHO Histological Classificat...

Discussions by experts

A brief discussion on pathogenesis of primary biliary cirrhosis

Wang WeiBin, Zhu YouFu

2013, 29(11): 805-809. DOI: 10.3969/j.issn.1001-5256.2013.11.002

Abstract(3103)

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Abstract:
The pathogenesis of primary biliary cirrhosis ( PBC) is unknown. Researchers have found that monozygotic twins have a higher concordance rate for PBC than dizygotic twins, and the phenomenon of familial aggregation and the results of genome- wide association studies also demonstrate the importance o...

Genetic variation and significance of hepatitis B surface antigen

Zhang ZhenHua, Deng WanYu, Lu MengJi, Yang DongLiang

2013, 29(11): 810-815. DOI: 10.3969/j.issn.1001-5256.2013.11.003

Abstract(3182)

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Abstract:
Hepatitis B virus ( HBV) is prone to genetic variation because there is reverse transcription in the process of HBV replication.The gene mutation of hepatitis B surface antigen may affect clinical diagnosis of HBV infection, viral replication, and vaccine effect. The current research and existing pr...

Targeted therapy of liver fibrosis on the horizon

Chen PingSheng, Liu Jing

2013, 29(11): 816-819. DOI: 10.3969/j.issn.1001-5256.2013.11.004

Abstract(3020)

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Abstract:
Over the past few years, significant advances have occurred in the targeted therapy of liver fibrosis. However, it is still a big challenge to deliver drugs to target cells and exert desirable therapeutic effect. The research on targeted therapy of liver fibrosis, including the types of target cells...

Original articles_Viral hepatitis

Predictive value of HBcrAg for lamivudine resistance in patients with chronic hepatitis B

Liu Cheng, Mu YongPing, Yang ZongGuo, Chen XiaoRong, Lu YunFei, Xu QingNian

2013, 29(11): 820-823. DOI: 10.3969/j.issn.1001-5256.2013.11.005

Abstract(2961)

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Abstract:
Objective To evaluate the predictive value of hepatitis B virus ( HBV) core- related antigen ( HBcrAg) for the lamivudine ( LAM) resistance in patients with chronic hepatitis B. Methods Forty- three patients with previously untreated chronic hepatitis B who were treated in the inpatient department a...

Efficacy and safety of pegylated interferon in patients with chronic hepatitis C in China: meta- analysis

Wang TingTing, Jiang YingAn, Yang LiHua, Zhou ZhenDong

2013, 29(11): 824-827. DOI: 10.3969/j.issn.1001-5256.2013.10.006

Abstract(0)

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Abstract:
Objective To evaluate the efficacy and safety of pegylated interferon in patients with chronic hepatitis C in China. Methods A search was performed using the Cochrane Central Register of Controlled Trials ( Cochrane Library, Issue 11, 2012) , OVID EBM Reviews, CNKI, and Wanfang database to identify ...

Genotypes of HCV in hepatitis C patients of Han nationality in Gansu, China

Peng XueBin, Mao XiaoRong, Chen Hong

2013, 29(11): 828-831. DOI: 10.3969/j.issn.1001-5256.2013.11.007

Abstract(3029)

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Abstract:
Objective To investigate the genotypes of hepatitis C virus ( HCV) among the hepatitis C patients of Han nationality in Gansu, China, as well as their possible routes of transmission and relationship with clinical indices. Methods The complete data regarding hepatitis C, including sex, age, possible...

Relationship between hepatitis C virus genotypes and viral load in Chenzhou, China

Gu Bin, Huang HuiQin, Hou XiaoLan, Ning Feng, Zhang Yan, Li Lu

2013, 29(11): 832-834. DOI: 10.3969/j.issn.1001-5256.2013.11.008

Abstract(3143)

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Abstract:
Objective To investigate the epidemiological characteristics of hepatitis C and the genotypes of hepatitis C virus ( HCV) in Chenzhou, Hunan Province, China, and to analyze the difference in HCV RNA load between genotype 1 patients and non- genotype 1 patients. Methods Sixty hepatitis C patients wit...

Effects of different anti- HIV therapies on progression of hepatitis C in HCV / HIV- coinfected patients

Sun HongQing, Huang Qin, Shen Fang, Wu Min, Zhou XiaoMing, Cai WeiPing, Hu YunWen

2013, 29(11): 835-838. DOI: 10.3969/j.issn.1001-5256.2013.11.009

Abstract(3038)

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Abstract:
Objective To investigate the effect of protease inhibitors ( PIs) - or non- nucleoside reverse transcriptase inhibitors ( NNRTIs) - based therapy on the progression of hepatitis C in patients with hepatitis C virus ( HCV) / human immunodeficiency virus ( HIV) coinfection. Methods A total of 273 pati...

Original articles_Liver fibrosis and liver cirrhosis

Therapeutic effect of autologous bone marrow stem cell transplantation through portal vein or hepatic artery in treatment of decompensated liver cirrhosis: a comparative study

Wang Fang, Kou JunFeng, Yun ShengHao, Cai GuoFang, Wang KeJing, Yang XingKun

2013, 29(11): 844-847. DOI: 10.3969/j.issn.1001-5256.2013.11.011

Abstract(3019)

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Abstract:
Objective To conduct a comparative study on the therapeutic effect and safety of autologous bone marrow stem cell transplantation through the portal vein or hepatic artery in the treatment of decompensated liver cirrhosis. Methods A retrospective analysis was performed on the clinical data of 50 pat...

Effect of autologous bone marrow- derived mesenchymal stem cells on portal hemodynamics in patients with liver cirrhosis

Shang JianZhong, Ma LongFei, Ma HongWei, Zhao QiuFang, Zhao LinHua, Li XiaoFei, Fan YanFeng, Zhang SuE

2013, 29(11): 848-851. DOI: 10.3969/j.issn.1001-5256.2013.10.012

Abstract(2568)

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Abstract:
Objective To observe the effect of autologous bone marrow- derived mesenchymal stem cells ( BMMSCs) on the portal hemodynamics in patients with hepatitis B virus ( HBV) - related decompensated cirrhosis. Methods Forty- six patients with HBV- related decompensated cirrhosis, who were admitted to the ...

Predictive factors for mortality in patients with alcoholic cirrhosis

Xie YanDi, Feng Bo, Gao Yan, Wei Lai

2013, 29(11): 852-857. DOI: 10.3969/j.issn.1001-5256.2013.10.013

Abstract(2653)

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Abstract:
Objective To describe the clinical characteristics of alcoholic cirrhosis ( AC) , analyze the relationship of alcohol intake with development of AC, and compare the predictive values of biochemical parameters, complications, Child- Turcotte- Pugh ( CTP) score, Model for End- Stage Liver Disease ( ME...

Species of pathogens and drug selection in liver cirrhosis patients with sepsis

Zhang Lan, Cui EnBo, Bao ChunMei, Zhang JuLing, Wang Huan, Chen SuMing, Zhang ChengLong, Mao YuanLi, Qu Fen

2013, 29(11): 858-862. DOI: 10.3969/j.issn.1001-5256.2013.11.014

Abstract(3175)

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Abstract:
Objective To identify the species of pathogens in liver cirrhosis patients with sepsis and screen out the effective antibiotics, and to provide a basis for effective clinical antimicrobial therapy. Methods Blood samples were collected from liver cirrhosis patients with suspected bloodstream infectio...

Brief reports

Clinicopathological features of hepatocellular lymphoepithelioma- like carcinoma: case report and review of the literature

Li GuiMei, Yang ZhiHui, Gao Hong, Yin ZhengJin

2013, 29(11): 871-873. DOI: 10.3969/j.issn.1001-5256.2013.11.017

Abstract(2808)

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Abstract:

Reviews

The research in liver tissue pathology of chronic HBV infection patients

Shang DanHe, Chen YanPing, Li ChunYan

2013, 29(11): 874-877. DOI: 10.3969/j.issn.1001-5256.2013.11.018

Abstract(2867)

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Abstract:
Histopathological examination of the liver is the most direct method for evaluating the pathological changes of the liver in patients with chronic hepatitis B virus ( HBV) infection. Generally, the patients with chronic HBV infection who show normal or slightly elevated serum alanine transaminase ( ...

Research progress in role of augmenter of liver regeneration in the liver

Shi HongBo, Duan ZhongPing

2013, 29(11): 878-881. DOI: 10.3969/j.issn.1001-5256.2013.11.019

Abstract(3105)

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Abstract:
Recent studies have found that augmenter of liver regeneration ( ALR) not only promotes liver regeneration and protects the liver from damage, but may also play an important role in the formation and development of the liver. The recent progress in research on the biological function and action mech...

Relationship between laboratory parameters and liver pathology in patients with nonalcoholic steatohepatitis

Chang BinXia, Teng GuangJu, Sun Ying, Zhao Jun, Zhang Wei, Huo DanDan, Zheng RuiDan, Zou ZhengSheng, Li BaoSen

2013, 29(11): 839-843. DOI: 10.3969/j.issn.1001-5256.2013.11.010

Abstract(2909)

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Abstract:
Objective To investigate the relationship between laboratory parameters and pathological features of the liver in patients with nonalcoholic steatohepatitis ( NASH) and to provide some information for the diagnosis and prognosis of NASH. Methods A retrospective analysis was performed on the clinical...

Effects of silencing glypican- 3 gene transcription on proliferation and apoptosis of hepatoma cells

Tai BoJun, Yao Min, Gu Xing, Shi Yun, Yu DanDan, Chen Jie, Zheng WenJie, Yao DengFu, Lu ShaoLin

2013, 29(11): 863-866. DOI: 10.3969/j.issn.1001-5256.2013.10.015

Abstract(1733)

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Abstract:
Objective To investigate the effects of silencing glypican-3 ( GPC-3) gene transcription by shRNA on the proliferation and apoptosis of hepatoma cells. Methods GPC- 3- shRNA was inserted into pGPU6 / GFP/ Neo vector, and HepG2 cells were transfected with the vector.The mRNA and protein expression of...

Roles of indocyanine green clearance test and 13C- methacetin breath test in assessing liver function in acute liver injury: a comparative study

Mao JingYi, Li Xin, Wang Chen, Xu YouQing

2013, 29(11): 867-870. DOI: 10.3969/j.issn.1001-5256.2013.11.016

Abstract(2487)

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Abstract:
Objective To conduct a comparative study of indocyanine green ( ICG) clearance test and13C- methacetin breath test (13C- MBT) in assessing the liver function in acute liver injury. Methods Forty- eight male Sprague- Dawley rats were randomly divided into control group and 6, 12, 24, 48, and 72 h mod...