The research in liver tissue pathology of chronic HBV infection patients

[1]LIAW YF, LEUNG N, KAO JH, et al.Asian-Pacific consensus statement on the management of chronic hepatitis B:a 2008 update[J].Hepatol Int, 2008, 2 (3) :263-283.[2]LOK AS, McMAHON BJ.Chronic hepatitis B:update 2009[J].Hepatology, 2009, 50 (3) :661-662.[3]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B (2010 version) [J].J Clin Hepatol, 2011, 27 (1) :1-16. (in Chinese) 中华医学肝病学分会, 中华医学会感染分会.中国慢性乙型肝炎防治指南 (2010版) [J].临床肝胆病杂志, 2011, 27 (1) :1-16.[4]CHEN EQ, HE LL, WANG LC, et al.Change of liver histology in chronic hepatitis B patients with alanine aminotransferase less than two-time up limits of normal[J].World Chin J Dig, 2008, 16 (22) :2476-2481. (in Chinese) 陈恩强, 何伶俐, 王丽春, 等.丙氨酸氨基转移酶低于2倍正常值的慢性乙肝患者肝组织学的改变[J].世界华人消化杂志, 2008, 16 (22) :2476-2481.[5]KE J, XIE QX, ZHANG YF, et al.Influential factors for liver pathology in patients with chronic HBV infection:an analysis of 129cases[J].Chin J Infect Dis, 2012, 30 (8) :490-492. (in Chinese) 柯晶, 谢琴秀, 张亚飞, 等.慢性乙型肝炎病毒感染的129例患者肝组织学影响因素分析[J].中华传染病杂志, 2012, 30 (8) :490-492.[6]YING RS, YANG Z, CHEN YY, et al.Different liver histopathological features of chronic HBV infection patients with normal and mildly elevated serum ALT[J].Chin J Hepatol, 2012, 20 (8) :585-588. (in Chinese) 应若素, 杨湛, 陈燕宇, 等.丙氨基转移酶水平正常与轻度升高慢性HBV感染者的肝脏病理学特征比较[J].中华肝脏病杂志, 2012, 20 (8) :585-588.[7]HSU A, LAI CL, YUEN MF.Update on the risk of hepatocellular carcinoma in chronic hepatitis B virus infection[J].Curr Hepat Rep, 2011, 10 (2) :106-111.[8]CHU CM, LIAW YF.Incidence and risk factors of progression to cirrhosis in inactive carriers of hepatitis B virus[J].Am J Gastroenterol, 2009, 104 (7) :1693-1699.[9]LI L, YU HB, LYU J, et al.Analysis of risk factors about disease progression in patients with HBeAg positive chronic hepatitis B receiving liver biopsy[J].Beijing Med J, 2010, 32 (3) :210-213. (in Chinese) 李丽, 于海滨, 闾军, 等.HBeAg阳性慢性乙型肝炎肝活检患者病情进展的危险因素分析[J].北京医学, 2010, 32 (3) :210-213.[10]ZHENG Z.Relationship between HBV-DNA and HBeAg'aspartate aminotransferase and alanine aminotransferase in chronic hepatitis B patients with positive e Antigen[J].J Med Res, 2012, 41 (8) :164-166. (in Chinese) 郑专.e抗原阳性的乙型肝炎患者HBV-DNA载量与HBsAg以及肝功能关系的研究[J].医学研究杂志, 2012, 41 (8) :164-166.[11]ZENG DW, DONG J, ZHU YY, et al.The relationship between different serum HBeAg levels and pathological stages of patients with chronic hepatitis B[J].Chin J Infect Dis, 2012, 30 (8) :468-471. (in Chinese) 曾达武, 董菁, 朱月永, 等.HBeAg水平与免疫耐受期慢性乙型肝炎患者的临床病理关系[J].中华传染病杂志, 2012, 30 (8) :468-471.[12]TANG X, YUAN T, WANG M, et al.Pathological changes of liver in HBeAg-positive and HBeAg-negative patients with chronic hepatitis B:a comparative analysis of 171 cases[J].Pract Clin Med, 2011, 12 (7) :8-9. (in Chinese) 汤雄, 袁涛, 汪梦, 等.171例HBeAg阳性与阴性慢性乙型肝炎患者肝脏组织学的对比分析[J].实用临床医学, 2011, 12 (7) :8-9.[13]WU LP, ZHANG JJ, DU RQ, et al.The correlation between HBV DNA and liver inflammation/fibrosis stage in HBeAg positive and negative chronic hepatitis B patients[J].Chin Hepatol, 2009, 14 (2) :269-271. (in Chinese) 吴丽萍, 张建军, 杜瑞清, 等.肝功能正常的慢性乙型肝炎病毒感染者血清HBeAg及HBV DNA与肝组织病理改变的关系[J].肝脏, 2009, 14 (2) :269-271.[14]MO ML, MO RH, GAN CL, et al.Study on correlation between serum HBeAg/HBV DNA level and pathological changes of liver tissues[J].J Clin Hepatol, 2009, 25 (4) :256-258. (in Chinese) 莫穆隆, 莫让辉, 甘楚林, 等.血清HBeAg、HBV DNA与肝组织病理的相关性分析[J].临床肝胆病杂志, 2009, 25 (4) :256-258.[15]WU CH, SI CW, TIAN GS, et al.An analysis of the pathohistology of liver tissues, clinical features and prognostic factors of chronic hepatitis B virus carriers[J].Chin J Hepatol, 2007, 15 (8) :577-581. (in Chinese) 吴赤红, 斯崇文, 田庚善, 等.慢性乙型肝炎病毒携带者的病理与临床及预后分析[J].中华肝脏病杂志, 2007, 15 (8) :577-581.[16]ZHOU WH, CHEN SY, FEI XW.The relation study between serum quantitative HBV-DNA, ALT level and liver lesions in patients with chronic hepatitis B[J].Exp Lab Med, 2011, 29 (4) :369-372. (in Chinese) 周文虹, 陈书裕, 费选文.慢性乙肝患者HBV-DNA定量与肝脏病理及血清ALT关系的探讨[J].实验与检验医学, 2011, 29 (4) :369-372.[17]AHN SH, CHANH LY.CHEN PJ, et al.Chronic hepatitis B:whom to treat and for how long?Propositions, challenges, and future directions[J].Hepatol Int, 2010, 4 (1) :386-395.[18]PARK BK, PARK YN, AHN SH, et al.Long-term outcome of chronic hepatitis B based on histological grade and stage[J].J Gastroenterol Hepatol, 2007, 22 (3) :383-388.[19]DOU XG.Anti-virus treatment strategies for chronic hepatitis B virus infection with normal alanine aminotransferase[J].Chin J Pract Intern Med, 2013, 33 (6) :454-456. (in Chinese) 窦晓光.丙氨酸转氨酶正常的慢性乙型肝炎病毒感染人群抗病毒治疗策略[J].中国实用内科杂志, 2013, 33 (6) :454-456.[20]TAI DI, LIN SM, SHEE IS, et al.Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time[J].Hepatology, 2009, 49 (6) :1859-1867.[21]LIAW YF, CHU CM.Hepatitis B virus infection[J].Lancet, 2009, 373 (9663) :582-592.[22]KIM WR, FLAMM SL, Di BISCEGLIE AM, et al.Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease[J].Hepatology, 2008, 47 (4) :1363-1370.[23]PARK JY, PARK YN, KIM DY, et al.High prevalence of significant histology in asymptomatic chronic hepatitis B patients with genotype C and high serum HBV DNA levels[J].J Viral Hepatol, 2008, 15 (8) :615-621.[24]TSANG PS, TRINH H, GARCIA RT, et al.Significant prevalence of histologic disease in patients with chronic hepatitis B and mildly elevated serum alanine aminotransferase levels[J].Clin Gastroenterol Hepatol, 2008, 6 (5) :569-574.[25]LAI M, HYATT BJ, NASSER I, et al.The clinical significance of persistently normal ALT in chronic hepatitis B infection[J].J Hepatol, 2007, 47 (6) :760-767.[26]LESMANA CR, GANI RA, HASAN I.Significant hepatic histopathology in chronic hepatitis B patients with serum ALT less than twice ULN and high HBV-DNA levels in Indonesia[J].J Dig Dis, 2011, 12 (6) :476-480.[27]ALAM S, AHMAD N, MUSTAFA G, et al.Evaluation of normal or minimally elevated alanine transaminase, age and DNA level in predicting liver histological changes in chronic hepatitis B[J].Liver Int, 2011, 31 (6) :824-830.[28]PARTI D, TAIOLI E, ZANELLA A, et al.Updated definition of healthy ranges for serum alanine aminotransferase levels[J].Ann Intern Med, 2002, 137 (1) :1-10.[29]SHANG DH, CHEN YP, XU GH, et al.Study on liver pathology in chronic hepatitis B patients with different ALT levels[J].Chin J Infect Dis, 2013, 31 (3) :183-184. (in Chinese) 尚丹鹤, 陈延平, 徐光华, 等.不同丙氨酸转移酶水平慢性乙型肝炎患者肝组织的病理学研究[J].中华传染病杂志, 2013, 31 (3) :183-184.[30]LIN CL, KAO JH.The clinical implications of hepatitis B virus genotype:Recent advances[J].J Gastroenterol Hepatol, 2011, 26 (Suppl 1) :123-130.[31]HUANG Y, WANG Z, AN S, et al.Role of hepatitis B virus genotypes and quantitative HBV DNA in metastasis and recurrence of hepatocellular carcinoma[J].J Med Virol, 2008, 80 (4) :591-597.[32]MOLINA-PREZ E, CASTROAGUDN JF, AGUILERA-GUIRAO A, et al.Viral and host factors related with histopathologyc activity in patients with chronic hepatitis B and moderate or intermittently elevated alanine aminotransferase levels[J].Rev Esp Enferm Dig, 2010, 102 (9) :519-525.[33]SáNCHEZ-TAPIAS JM, COSTA J, MAS A, et al.Influence of hepatitis B genotype on the long-term outcome of chronic hepatitis B in western patients[J].Gastroenterology, 2002, 123 (6) :1848-1856.[34]HE WP, HU JH, WANG HF.Relativity analysis of chronic hepatitis B virus genotype and clinical pathology[J].Chin J Exp Clin Virol, 2008, 22 (2) :116-118. (in Chinese) 何卫平, 胡瑾华, 王慧芬.慢性乙型肝炎病毒基因型与临床病理相关性分析[J].中华实验和临床病毒学杂志, 2008, 22 (2) :116-118.[35]ZHANG H, ZOU HB, MI YQ, et al.The relationship between HBV genotype and liver biopsy outcome of chronic HBV carriers[J].J Clin Hepatol, 2008, 24 (6) :413-414. (in Chinese) 张弘, 邹怀宾, 宓余强, 等.乙肝病毒携带者病毒基因型与肝组织病理变化的关系[J].临床肝胆病杂志, 2008, 24 (6) :413-414.[36]XIANG WQ, FENG WF, KE W, et al.Hepatitis B virus X protein stimulates IL-6 expression in the patocytes via a My D88-dependent pathway[J].J Hepatol, 2011, 54 (1) :26-33.[37]WANG F, ZHOU H, YANG Y, et al.Hepatitis B Virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway[J].Oncol Rep, 2012, 27 (4) :1170-1176.