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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2013
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Article Contents

Role and action mechanism of 8-iso-PGF2α in traumatic liver diseases

DOI: 10.3969/j.issn.1001-5256.2013.12.022
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  • Received Date: 2013-06-19
  • Published Date: 2013-12-20
  • Oxidative stress caused by reactive oxygen species changes the function of biofilm mainly by initiating membrane lipid peroxidation and causes varying degrees of liver damage along with a series of cytokines. As the specific product of lipid peroxidation, 8-iso-PGF2α has strong bioactivity and is currently considered the gold indicator for evaluating oxidative stress and lipid peroxidation damage. The relationship between traumatic liver diseases and lipid peroxidation is summarized; 8-iso-PGF2α is recommended as a sensitive indicator of peroxidative damage in liver diseases, and its potential use in liver diseases is preliminarily discussed.

     

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  • [1]MURIEL P.Role of free radicals in liver diseases[J].Hepatol Int, 2009, 3 (4) :526-536.
    [2]MEZZETTI A, CIPOLLONE F, CUCCURULLO F.Oxidative stress and cardiovascular complications in diabetes:isoprostanes as new markers on an old paradigm[J].Cardiovasc Res, 2000, 47 (3) :475-488.
    [3]YANG LL, LIU T, WANG M, et al.Oxidative stress and non-alcoholic fatty liver disease research progress[J].World Chin J Digestol, 2009, 17 (9) :896-900. (in Chinese) 杨丽丽, 柳涛, 王淼, 等.氧化应激与非酒精性脂肪性肝病研究进展[J].世界华人消化杂志, 2009, 17 (9) :896-900.
    [4]KUMAR A, KINQDON E, NORMAN J, et al.The isoprostane 8-iso-PGF2 alpha suppresses monocyte adhesion to human microvascular endothelial cells via two independent mechanisms[J].FASEB J, 2005, 19 (3) :443-445.
    [5]WANG X, CEDERBAUM AI.Acute ethanol pretreatment increase FAS-mediated liver injury in mice role of oxidative stress and CYP2E1-dependent and independent pathway[J].Free Radic Biol Med, 2007, 42 (7) :971-984.
    [6]WANG X, ENO CO, ALTMAN BJ, et al.ERstress modulates cellular metabolism[J].Biochem J, 2011, 435 (1) :285-296.
    [7]YANG BZ, REN F, DUAN ZP, et al.Endoplasmic reticulum stress and viral hepatitis[J].Chin J Gastroenterol Hepatol, 2013, 22 (2) :167-170. (in Chinese) 杨丙章, 任锋, 段钟平, 等.内质网应激与病毒性肝炎[J].胃肠病学和肝病学杂志, 2013, 22 (2) :167-170.
    [8]FENG LJ, SHEN YX, LI J.Endoplasmic reticulum stress and inflammation[J].Chin Pharmacol Bull, 2013, 29 (6) :756-760. (in Chinese) 冯利杰, 沈玉先, 李俊.内质网应激与炎症[J].中国药理学通报, 2013, 29 (6) :756-760.
    [9]CHOI J, OU JH.Mechanism of liver injury.Ⅲ.Oxidative stress in the pathogenesis of hepatitis C virus[J].Am J Physiol Gastrointest Liver Physiol, 2006, 290:g847-g851.
    [10]JOYCE MA, WALTERS KA, LAMB SE, et al.HCV induces oxidative and ER stress, and sensitize infected cells to apoptosis in SCID/AlbuPA mice[J].PLoS Pathog, 2009, 5 (2) :e1000291.
    [11]CHRISTEN V, TREVES S, DUONG FH, et al.Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A[J].Hepatology, 2007, 46 (2) :558-565.
    [12]MENG XB.Patients withchronic hepatitis B SF, serum IGF-Ilevels and the relationship between lipid peroxidation[J].J Radioimmunol, 2011, 24 (2) :133-135. (in Chinese) 孟晓波.慢性乙型肝炎患者SF、血清IGF-I水平与脂质过氧化损伤的关系[J].放射免疫学杂志, 2011, 24 (2) :133-135.
    [13]LEE UE, FRIEDMAN SL.Mechanisms of hepatic fibrogenesis[J].Best Pract Res Clin Gastroenterol, 2011, 25 (2) :195-206.
    [14]MANNAERTS I, NUYTTEN NR, ROGIERS V, et al.Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo[J].Hepatology, 2010, 51 (2) :603-614.
    [15]WANG J, LECLERCQ I, BRYMORA JM, et al.Kupffer cells mediate leptin induced liver fibrosis[J].Gastroenterology, 2009, 137 (7) :713-723.
    [16]BRUNATI AM, PAGANO MA, BINDOLI A, et al.Thiol redox systems and protein kinases in hepatic stellate cell regulatory processes[J].Free Radic Res, 2010, 44 (4) :363-378.
    [17]ZHU BH, ZHANG HF, CHEN YP.TGF-1 in rat liver fibrosis tissue research[J].Chin J Microecol, 2013, 25 (2) :150-152. (in Chinese) 朱碧红, 张慧芳, 陈永平.大鼠肝纤维化组织中TGF-1的研究[J].中国微生态学杂志, 2013, 25 (2) :150-152.
    [18]STARKEL P, SEMPOUX C, LECLERCQ I, et al.Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats[J].J Hepatol, 2003, 39 (4) :538-546.
    [19]ZHANG LF, WEI W, XU JM, et al.Inhibitory effect of melatonin on diquat-induced lipid peroxidation in vivo as assessed by the measurement of F2-isoprostanes[J].Pineal Res, 2006, 40 (4) :326-331.
    [20]COMPORTI M, AREZZINI B, SIGNORINI C, et al.F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells:a link with liver fibrosis?[J].Lab Invest, 2005, 85 (11) :1381-1391.
    [21]FANG L, DU SY, ZHAO HC, et al.Role of oxidative stress in the pathogenesis of chronic hepatic injury induced by ethanol and carbon tetrachloride in rats[J].World Chin J Digestol, 2010, 18 (3) :234-239.
    [22]ZHU H, JIA Z, MISRA H, et al.Oxidative stress and redox signaling mechanisms of alcoholic liver disease:Updated experimental and clinical evidence[J].J Dig Dis, 2012, 13 (3) :133-142.
    [23]LAMLE J, MARHENKE S, BORLAK J, et al.Nuclear factor-eythroid2-related factor 2 prevents alcohol-induced fulminant liver injury[J].Gastroenterology, 2008, 134 (4) :1159-1168.
    [24]KLAASSEN CD, REISMAN SA.Nrf2 the rescue:effects of the antioxidative/electrophilic response on the liver[J].Toxicol Appl Pharmacol, 2010, 244 (1) :57-65.
    [25]PESSAYRE D.Role of mitochondria in non-alcoholic fatty liver disease[J].J Gastroenterol Hepatol, 2007, 22 (Suppl 1) :s20-s27.
    [26]LIU Y, LI CP.The role of oxygen stress and lipid peroxidation and liver cell apoptosis in nonalcoholic fatty liver disease[J].Southwest Med, 2008, 10 (4) :3-6. (in Chinese) 刘翼, 李昌平.氧应激、脂质过氧化及肝细胞凋亡在非酒精性脂肪肝病中的作用[J].西南军医, 2008, 10 (4) :3-6.
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