Significance of factor V Leiden mutation in Budd- Chiari syndrome and portal vein thrombosis

Hu FengRong; Gao Fan; Yang Qing; Qi XingShun

doi:10.3969/j.issn.1001-5256.2014.01.025

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Jan. 2014

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Article Navigation > Journal of Clinical Hepatology > 2014 > 30(1): 86-89

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Significance of factor V Leiden mutation in Budd- Chiari syndrome and portal vein thrombosis

DOI: 10.3969/j.issn.1001-5256.2014.01.025

Department of Gastroenterology, No. 2 Hospital of Xi'an

Research funding:

Received Date: 2013-05-23
Published Date: 2014-01-20

Abstract

Abstract

Budd- Chiari syndrome and portal vein thrombosis are two rare vascular disorders of the liver and may be complicated by severe diseases like liver failure and portal hypertension. Studies have shown that factor V Leiden ( FVL) mutation is an important risk factor for both Budd- Chiari syndrome and portal vein thrombosis in Western countries. However, FVL mutation is rarely observed in Chinese patients with Budd- Chiari syndrome. The significance of FVL mutation in the pathogenesis of Budd- Chiari syndrome and portal vein thrombosis is reviewed. It is suggested that prospective studies regarding the prevalence of FVL mutation in Chinese patients with portal vein thrombosis are warranted to judge the necessity of screening for FVL mutation.
- Budd-Chiari syndrome,
- venous thromboembolism,
- factor V,
- mutation, missense

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References(28)

References

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Significance of factor V Leiden mutation in Budd- Chiari syndrome and portal vein thrombosis

DOI: 10.3969/j.issn.1001-5256.2014.01.025