Hepatocellular carcinoma ( HCC) is a progressive, multi- center, and multi- cause disease. Nowadays, numerous drugs have been investigated in clinical trials for treatment of HCC, but the prognosis was usually poor because HCC is highly invasive and metastatic. The structural characteristics and biological properties of clusterin ( CLU) are described; the research progress in relationship of secretory CLU ( sCLU) with the development and progression of HCC is summarized, and it is pointed out that the overexpression of CLU may promote cancer metastasis, induce epithelial- mesenchymal transition, inhibit apoptosis of HCC cells, and lead to resistance to chemotherapy drugs. In addition, the molecular structure of second- generation antisense nucleic acid drug Custirsen, which may downregulate the metastasis of HCC in vitro, is briefly presented. It is suggested that sCLU promotes the development and progression of HCC in many ways and deserves further research for its molecular mechanism of action.
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