Great changes have taken place in the studies on liver cancer over the past 50 years. The main evolution and perspectives are reviewed as follows: ( 1) Infections with hepatitis B virus and hepatitis C virus, environmental factors, lifestyle, and metabolic, endocrine, and hereditary factors have bec...

The treatment modality for malignant tumor is changing from traditional single treatment to combined treatment and then to multidisciplinary comprehensive treatment. Based on the holistic medicine view, the author proposes the multidisciplinary holistic treatment ( MDHT) model to design and implemen...

In recent years, with the development of medical technology, the treatment outcome of hepatocellular carcinoma ( HCC) has improved substantially. However, the treatment of large HCC is still a difficult clinical problem. The biological characteristics of large HCC, as well as the surgical treatments...

As an inhibitor of fibroblast growth factor receptor ( FGFR) - 1, FGFR- 2, FGFR- 3, vascular endothelial growth factor receptor ( VEGFR) - 2, and VEGFR- 3, brivanib can inhibit tumor angiogenesis and growth. Phase Ⅰ and Ⅱ clinical trials have demonstrated the safety and efficacy of brivanib in the t...

Regorafenib, a novel multi- kinase inhibitor, has been approved for the treatment of metastatic colorectal cancer and gastrointestinal stromal tumors. The clinical trials of Regorafenib for the treatment of hepatocellular carcinoma ( HCC) are summarized. Phase Ⅰ and Ⅱ clinical trials have demonstrat...

With the rising incidence and mortality of HCC, accurate, simple, and non- invasive biomarkers are increasingly needed for the early diagnosis of this disease. MicroRNAs ( miRNAs) are a class of endogenous non- coding small RNAs, which have been widely found in animals, plants, and viruses and are s...

Hepatocellular cancer ( HCC) is characterized by insidious onset, difficult early diagnosis, and rapid progression, and less than 30% of patients have the chance of being surgically treated when diagnosed with this disease. Therefore, non- surgical treatment is the main treatment modality for advanc...

Pancreatic cancer ( PC) has the worst prognosis among all cancers, with a 5- year survival rate of less than 20% in patients with early local disease. The surgical treatment of PC has reached a plateau. Although novel drugs and treatment techniques have been increasingly applied, the survival of PC ...

Objective To investigate the value of contrast- enhanced ultrasound ( CEUS) in the hepatectomy for primary liver cancer. Methods The clinical data of 42 patients who underwent CEUS- guided hepatectomy for primary liver cancer in the department of hepatobiliary surgery of our hospital from January 20...

Objective To compare three- dimensional conformal radiotherapy ( 3DCRT) and intensity- modulated radiotherapy ( IMRT) in terms of their advantages of disadvantages in the treatment of primary hepatocellular carcinoma ( PHC) with portal vein tumor thrombus ( PVTT) . Methods Twenty patients with PHC a...

Objective To measure the expression of Gremlin- 1 in the peripheral blood mononuclear cells ( PBMCs) and liver tissues of patients with primary liver cancer and liver cirrhosis. Methods PBMCs were obtained from 21 patients with primary liver cancer and 17 patients with liver cirrhosis during June to...

Objective To investigate the expression of Caspase- 9 and Survivin in hepatocellular carcinoma ( HCC) tissues and its clinical significance. Methods The immunohistochemical SP method was used to measure the expression of Caspase- 9 and Survivin in the HCC tissues and paracancerous normal liver tissu...

Objective To investigate the efficacy of argon- helium cryoablation combined with I125particle implantation in the treatment of hilar cholangiocarcinoma. Methods Five patients with hilar cholangiocarcinoma who were admitted to our hospital from January 2010 to June 2013 were selected. Under CT local...

Objective To investigate the expression of delta drosophila homolog- like 1 ( DLK1) and matrix metalloproteinase 9 ( MMP- 9) in cholangiocarcinoma tissue and to analyse their clinical significance and the correlation between DLK1 and MMP- 9. Methods Cholangiocarcinoma tissues were collected from 96 ...

Objective To establish a three- dimensional ( 3D) cell culture model for gallbladder carcinoma ( GC) cells and to investigate the killing effect of a novel nano- drug delivery system on GC cells and its action mechanism. Methods Two- dimensional ( 2D) and 3D cell culture models for GC GBC- SD cells ...

Objective To amplify and determine the hepatitis B virus ( HBV) reverse transcriptase ( RT) sequences of 153 Chinese patients with chronic HBV infection and investigate the drug resistance mutations related to nucleos ( t) ide analogues, and to analyze if there are drug resistance mutations which mi...

Sorafenib can significantly improve the prognosis of patients with advanced hepatocellular carcinoma ( HCC) , and it acts as an antagonist of the anti- angiogenic targets of vascular endothelial growth factor receptors and platelet- derived growth factor receptors and an inhibitor of the Raf / MEK /...

Hepatocellular carcinoma ( HCC) is a progressive, multi- center, and multi- cause disease. Nowadays, numerous drugs have been investigated in clinical trials for treatment of HCC, but the prognosis was usually poor because HCC is highly invasive and metastatic. The structural characteristics and bio...

A growing body of literature highlights the cross- talk between tumor cells and the surrounding peritumoral stroma as a key modulator in the development, invasion, and metastasis of hepatocellular carcinoma ( HCC) . Hepatic stellate cells ( HSC) , an important component in the microenvironment of HC...