Objective To investigate the significance of serum cystatin C (CysC) level for the early diagnosis of acute kidney injury (AKI) in patients with acute- on- chronic liver failure (ACLF) . Methods Sixty patients with chronic hepatitis B- related ACLF and 60 patients with CHB, as well as 60 healthy controls, were included in the study. The ACLF patients were followed up until discharge, and serum samples were collected during hospital stay. Serum CysC level was measured by latex- enhanced immunoturbidimetric assay. The receiver operating characteristic (ROC) curves of serum CysC, creatinine (Cr) , and sodium levels for the diagnosis of AKI were drawn, and the areas under the ROC curves (AUCs) and optimal cut- off values were determined. For normally distributed measurement data, comparison between groups was made by one- way analysis of variance, and multiple comparisons were made by two- sided t test; otherwise, comparison between groups was made by Mann- Whitney U test. Enumeration data were analyzed by chi- square test. The Pearson correlation test was used for correlation analysis. The AUCs and optimal cut- off values were calculated by Medcal 12. 7. 1. 0. Results The serum CysC level in ACLF patients was 1050 ± 444 ng /ml, which was significantly higher than those in healthy controls (638 ± 275 ng /ml, P = 0. 016) and CHB patients (661 ± 225 ng /ml, P = 0. 028) ; for ACLF patients, serum CysC level was not significantly correlated with serum Cr level (r =0.311, P >0.05) , but showed a significant positive correlation with MELD score (r =0. 529, P <0. 01) . During hospital stay, 8 (13.3%) of ACLF patients developed AKI. The multivariate logistic regression analysis indicated that serum CysC level was the independent risk factor for AKI development in ACLF patients (OR = 1. 008, P = 0. 021) . The cut- off value of serum CysC level for the early diagnosis of AKI in ACLF patients was 1210 ng /ml. Conclusion Elevated serum CysC level may provide an early prediction of AKI development in ACLF patients with a normal serum Cr level during hospital stay.
本研究旨在通过分析2016年—2020年中国(不含港澳台地区)作者在SCIE(Science Citation Index Expanded)数据库收录的胃肠肝病学期刊发表的肝脏疾病研究的题录数据与来源期刊的特征,评价中国作者发表的肝脏疾病研究出版物特征的变化趋势,了解中国学者在肝脏疾病研究领域的贡献;通过计算被中国与全球作者发表在胃肠肝病学期刊上的肝脏疾病研究引用频次,为评价中国作者发表的肝脏疾病研究的国际与国内影响力提供证据。
Table
3.
The proportion of liver disease research published by Chinese authors in different divisions of Gastroenterology & Hepatology journals indexed in SCIE accounted for the change in the proportion of liver diseases research published in the same division in the world during 2016 to 2020
Table
4.
The research on liver diseases published by Chinese authors in the Gastroenterology & Hepatology journals indexed in SCIE was funded by the National Natural Science Foundation of China during 2016 to 2020
Figure
1.
The distribution of citation frequency of Chinese authors' published liver diseases research in Q1 Gastroenterology and Hepatology journals during 2016 to 2020
Table
5.
The liver disease research published by Chinese authors in the Gastroenterology & Hepatology journals indexed in SCIE was the 9 most frequently cited studies of liver disease research published by Chinese authors and global authors in the Gastroenterology & Hepatology journals during 2016 to 2020
题名
期刊
出版年
通信作者单位
TC(排名)
GC(排名)
LC(排名)
Development of Diagnostic Criteria and A Prognostic Score for Hepatitis B Virus-Related Acute- On-Chronic Liver Failure
GUT
2018
浙江大学医学院附属第一医院
74(54)
20(6)
20(1)
Serum Hepatitis B Virus RNA is Encapsidated Pregenome RNA that may be Associated with Persistence of Viral Infection and Rebound
J HEPATOL
2016
北京大学
191(13)
45(1)
19(2)
New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment
HEPATOLOGY
2017
首都医科大学附属北京友谊医院
59(76)
18(7)
13(3)
Covered Tips Versus Endoscopic Band Ligation Plus Propranolol for The Prevention of Variceal Rebleeding in Cirrhotic Patients with Portal Vein Thrombosis: A Randomised Controlled Trial
GUT
2018
空军军医大学西京医院
50(103)
16(9)
11(4)
Targeting Hepatic Traf1-Ask1 Signaling to Improve Inflammation, Insulin Resistance, And Hepatic Steatosis
J HEPATOL
2016
武汉大学
73(58)
14(12)
11(4)
Liver Transplantation for Hepatocellular Carcinoma Beyond the Milan Criteria
GUT
2016
浙江大学医学院附属第一医院
95(40)
21(5)
10(6)
Targeting Traf3 Signaling Protects Against Hepatic Ischemia/Reperfusions Injury
J HEPATOL
2016
武汉大学
59(76)
10(21)
10(6)
Perioperative Blood Transfusion Does Not Influence Recurrence-Free and Overall Survivals After Curative Resection for Hepatocellular Carcinoma A Propensity Score Matching Analysis
J HEPATOL
2016
海军军医大学附属东方肝胆外科医院
69(60)
13(15)
9(8)
Circular RNA Circmto1 Acts as The Sponge of Microrna-9 To Suppress Hepatocellular Carcinoma Progression
HEPATOLOGY
2017
浙江大学,海军军医大学
664(1)
10(22)
9(8)
Eight Millimetre Covered Tips Does Not Compromise Shunt Function but Reduces Hepatic Encephalopathy in Preventing Variceal Rebleeding
J HEPATOL
2017
空军军医大学西京医院
56(86)
22(4)
8(10)
……
……
……
……
……
……
……
Comparison of Laboratory Tests, Ultrasound, or Magnetic Resonance Elastography to Detect Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
HEPATOLOGY
2017
华中科技大学同济医学院附属协和医院
238(9)
45(1)
7(12)
……
……
……
……
……
……
……
COVID-19: Abnormal Liver Function Tests
J HEPATOL
2020
南方科技大学第二附属医院
242(8)
26(3)
5(22)
Clinical Features of COVID-19-Related Liver Functional Abnormality
CLIN GASTROENTEROL HEPATOL
2020
复旦大学附属公共卫生临床中心
236(10)
17(8)
5(23)
注:J HEPATOL,Journal of Hepatology;CLIN GASTROENTEROL HEPATOL,Clinical Gastroenterology and Hepatology。
总被引频次可以用于评估出版物的影响力,但它假定所有引用的权重相同,具有明显的局限性。为了提高引文分析的可解释性,可以为引用加权,或者对施引文章和引用本身的特征进行限定[19]。胃肠肝病学期刊包括了肝病学专业期刊与消化病学专业期刊,其中Journal of Hepatology、Gut、Gastroenterology等高影响力期刊在全球享有盛誉。尽管中国作者也会在内科学期刊、医学综合期刊甚至多学科期刊发表肝脏疾病研究,但基本可以认为中国作者在专业期刊发表的肝脏疾病研究对于评价专科研究水平具有代表性,将来源期刊限定于胃肠肝病学期刊进行引文分析,有利于为认识肝脏疾病研究的影响力提供更加深入和巧妙的见解。
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CUI HL, XU L, LU T. Association of glucagon-like peptide-1 system with the prevention and treatment of nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2022, 38(6): 1406-1410. DOI: 10.3969/j.issn.1001-5256.2022.06.039.
CUI HL, XU L, LU T. Association of glucagon-like peptide-1 system with the prevention and treatment of nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2022, 38(6): 1406-1410. DOI: 10.3969/j.issn.1001-5256.2022.06.039.
Table
3.
The proportion of liver disease research published by Chinese authors in different divisions of Gastroenterology & Hepatology journals indexed in SCIE accounted for the change in the proportion of liver diseases research published in the same division in the world during 2016 to 2020
Table
4.
The research on liver diseases published by Chinese authors in the Gastroenterology & Hepatology journals indexed in SCIE was funded by the National Natural Science Foundation of China during 2016 to 2020
Table
5.
The liver disease research published by Chinese authors in the Gastroenterology & Hepatology journals indexed in SCIE was the 9 most frequently cited studies of liver disease research published by Chinese authors and global authors in the Gastroenterology & Hepatology journals during 2016 to 2020
题名
期刊
出版年
通信作者单位
TC(排名)
GC(排名)
LC(排名)
Development of Diagnostic Criteria and A Prognostic Score for Hepatitis B Virus-Related Acute- On-Chronic Liver Failure
GUT
2018
浙江大学医学院附属第一医院
74(54)
20(6)
20(1)
Serum Hepatitis B Virus RNA is Encapsidated Pregenome RNA that may be Associated with Persistence of Viral Infection and Rebound
J HEPATOL
2016
北京大学
191(13)
45(1)
19(2)
New Classification of Liver Biopsy Assessment for Fibrosis in Chronic Hepatitis B Patients Before and After Treatment
HEPATOLOGY
2017
首都医科大学附属北京友谊医院
59(76)
18(7)
13(3)
Covered Tips Versus Endoscopic Band Ligation Plus Propranolol for The Prevention of Variceal Rebleeding in Cirrhotic Patients with Portal Vein Thrombosis: A Randomised Controlled Trial
GUT
2018
空军军医大学西京医院
50(103)
16(9)
11(4)
Targeting Hepatic Traf1-Ask1 Signaling to Improve Inflammation, Insulin Resistance, And Hepatic Steatosis
J HEPATOL
2016
武汉大学
73(58)
14(12)
11(4)
Liver Transplantation for Hepatocellular Carcinoma Beyond the Milan Criteria
GUT
2016
浙江大学医学院附属第一医院
95(40)
21(5)
10(6)
Targeting Traf3 Signaling Protects Against Hepatic Ischemia/Reperfusions Injury
J HEPATOL
2016
武汉大学
59(76)
10(21)
10(6)
Perioperative Blood Transfusion Does Not Influence Recurrence-Free and Overall Survivals After Curative Resection for Hepatocellular Carcinoma A Propensity Score Matching Analysis
J HEPATOL
2016
海军军医大学附属东方肝胆外科医院
69(60)
13(15)
9(8)
Circular RNA Circmto1 Acts as The Sponge of Microrna-9 To Suppress Hepatocellular Carcinoma Progression
HEPATOLOGY
2017
浙江大学,海军军医大学
664(1)
10(22)
9(8)
Eight Millimetre Covered Tips Does Not Compromise Shunt Function but Reduces Hepatic Encephalopathy in Preventing Variceal Rebleeding
J HEPATOL
2017
空军军医大学西京医院
56(86)
22(4)
8(10)
……
……
……
……
……
……
……
Comparison of Laboratory Tests, Ultrasound, or Magnetic Resonance Elastography to Detect Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
HEPATOLOGY
2017
华中科技大学同济医学院附属协和医院
238(9)
45(1)
7(12)
……
……
……
……
……
……
……
COVID-19: Abnormal Liver Function Tests
J HEPATOL
2020
南方科技大学第二附属医院
242(8)
26(3)
5(22)
Clinical Features of COVID-19-Related Liver Functional Abnormality
CLIN GASTROENTEROL HEPATOL
2020
复旦大学附属公共卫生临床中心
236(10)
17(8)
5(23)
注:J HEPATOL,Journal of Hepatology;CLIN GASTROENTEROL HEPATOL,Clinical Gastroenterology and Hepatology。