2014 No. 7

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Editorial

Diagnosis and assessment of liver cirrhosis

Lu LunGen, Li ZhengHong

2014, 30(7): 577-579. DOI: 10.3969/j.issn.1001-5256.2014.07.001

Abstract(2520)

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Abstract:
Liver cirrhosis is the end stage of various chronic liver diseases. Early diagnosis and staging of liver cirrhosis, as well as effective disease assessment, are of great clinical significance. The application of liver biopsy, serological testing, and radiological examination in the clinical diagnosi...

Therapeutic guidelines

Expert consenus on antiviral therapy for special patients with chronic hepatitis B: an update in 2014

Yan Jie, Xie Wen

2014, 30(7): 580-587. DOI: 10.3969/j.issn.1001-5256.2014.07.002

Abstract(214)

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Abstract:

Bacterial infections in cirrhosis: a summary of position statement based on the EASL Special Conference 2013

Cai JunJun, Han Tao

2014, 30(7): 588-591. DOI: 10.3969/j.issn.1001-5256.2014.07.003

Abstract(3226)

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Abstract:

Explanation of the“Expert consensus on antiviral therapy to hepatitis B /C virus-related hepatocellular carcinoma”

Dong Jing, Jiang JiaJi

2014, 30(7): 592-595. DOI: 10.3969/j.issn.1001-5256.2014.07.004

Abstract(2684)

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Abstract:

Discussions by experts

Antiviral therapy for hepatitis B /C virus-related cirrhosis

Li YuYuan

2014, 30(7): 596-600. DOI: 10.3969/j.issn.1001-5256.2014.07.005

Abstract(2756)

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Abstract:
The necessity and feasibility of antiviral therapy in patients with liver cirrhosis have caught much attention. By summarizing the relevant guidelines /consensus statements and evidence- based medicine data in recent years, the advances in indications, strategies, drug options, and benefit /risk in ...

Controversial problems in management of cirrhotic ascites

Xie WeiFen, Ceng Xin

2014, 30(7): 601-603. DOI: 10.3969/j.issn.1001-5256.2014.07.006

Abstract(2912)

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Abstract:
Ascites is an important indicator of poor prognosis of liver cirrhosis. Although several guidelines and consensus statements on the management of ascites have been published in the past years, there are still a lot of controversial problems in this regard. The current controversial problems and diff...

Progress in clinical studies of noninvasive early diagnosis of liver fibrosis and cirrhosis

Zhou JiaLing, Wei Wei, You Hong

2014, 30(7): 604-607. DOI: 10.3969/j.issn.1001-5256.2014.07.007

Abstract(3132)

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Abstract:
The progression of liver fibrosis directly affects treatment options and prognosis. Early diagnosis and classification of liver fibrosis and dynamic monitoring are clinically needed. Noninvasive diagnostic techniques can avoid or reduce liver biopsy to enable early identification of liver fibrosis a...

Current status and progress in noninvasive assessment of portal pressure

Zhu YanJie, Wang Yong, Huang JiaLe, Qi XiaoLong, Yang ZhangQing

2014, 30(7): 608-611. DOI: 10.3969/j.issn.1001-5256.2014.07.008

Abstract(3014)

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Abstract:
Portal pressure assessment is a necessary means to diagnose portal hypertension. Currently, hepatic venous pressure gradient is considered as the diagnostic gold standard for portal hypertension. However, invasiveness is one of its most critical limitations. Therefore, a noninvasive, easy, and accur...

Application of HVPG in assessment of chronic liver diseases

Du Chao, Jiang MingDe

2014, 30(7): 612-615. DOI: 10.3969/j.issn.1001-5256.2014.07.009

Abstract(3423)

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Abstract:
The establishment and perfection of the assessment system for chronic liver diseases have a guiding significance for clinical diagnosis and treatment. Hepatic venous pressure gradient (HVPG) is of great significance in the progression of chronic liver diseases, and it is the only pathophysiological ...

Original articles_Liver fibrosis and liver cirrhosis

Diagnostic value of real-time tissue elastography for liver fibrosis in patients with chronic hepatitis B

Zhang GuoSheng, Wang TianYi, Xu YouQing, Zhou Li, Geng Nan, Chen Yu

2014, 30(7): 616-619. DOI: 10.3969/j.issn.1001-5256.2014.07.010

Abstract(2740)

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Abstract:
Objective To investigate the diagnostic value of real- time tissue elastography (RTE) in evaluating liver fibrosis in patients with chronic hepatitis B (CHB) . Methods Eighty- six patients with CHB, who visited Beijing Tiantan Hospital and Beijing You'an Hospital from March to August, 2013, were gro...

Value of FibroScan in diagnosis of hepatic fibrosis in patients with HBeAg-negative chronic hepatitis B

Luo JunHua, Ba YuanMing

2014, 30(7): 620-623. DOI: 10.3969/j.issn.1001-5256.2014.07.011

Abstract(2845)

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Abstract:
Objective To evaluate the value of transient elastography (FibroScan, FS) in predicting hepatic fibrosis in patients with HBeAg- negative chronic hepatitis B (CHB) . Methods One hundred and four patients with HBeAg- negative CHB, who were diagnosed and treated in Hubei Hospital of Traditional Chines...

Diagnostic values of FibroScan and FibroTouch for liver fibrosis: a comparative analysis

Wu Na, Zhang MingYuan, Wu RuiHong, Zhang YingWen, Jin JingLan, Zhu YingQiao, Niu JunQi

2014, 30(7): 624-627. DOI: 10.3969/j.issn.1001-5256.2014.07.012

Abstract(6642)

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Abstract:
Objective To compare the diagnostic values of FibroScan and FibroTouch for liver fibrosis. Methods A total of 962 patients who visited Department of Hepatology, The First Hospital of Jilin University from September 2013 to March 2014 were enrolled. FibroScan and FibroTouch were performed among these...

Short-term efficacy of EVL, EIS, and TAI in treatment of esophageal variceal bleeding

Zhou NianLan, Zhang MingJuan, Wang Su, Long AiHua, Xiang XiaoXing

2014, 30(7): 628-630. DOI: 10.3969/j.issn.1001-5256.2014.07.013

Abstract(3459)

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Abstract:
Objective To observe the changes in degree of varices, red signs, and portal hypertensive gastropathy in liver cirrhosis patients with esophageal variceal bleeding (EVB) after endoscopic variceal ligation ( EVL) , endoscopic injection sclerotherapy ( EIS) , and tissue adhesive injection (TAI) . Meth...

Serum Th1 /Th2 cytokine levels and their clinical significance in patients with alcoholic liver cirrhosis

Chen WeiHong, Chen Yan

2014, 30(7): 631-635. DOI: 10.3969/j.issn.1001-5256.2014.07.014

Abstract(3071)

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Abstract:
Objective To investigate the relationship of serum Th1 /Th2 cytokine levels with liver function and their clinical significance in patients with alcoholic liver cirrhosis (ALC) . Methods Thirty- four ALC patients, 13 patients with viral liver cirrhosis ( VLC) , and 17healthy controls were included i...

Original articles_Viral hepatitis

Forty-eight-week efficacy of adefovir dipivoxil alone versus combined with lamivudine in treatment of lamivudine-resistant HBeAg-positive chronic hepatitis B

Huang MeiJin, Tan HouJi, He YanZhuan, Huang QiWen, Zhou YaoNan, Qiu HaiXian

2014, 30(7): 636-638. DOI: 10.3969/j.issn.1001-5256.2014.07.015

Abstract(2628)

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Abstract:
Objective To observe the therapeutic efficacy and safety of adefovir dipivoxil (ADV) alone versus combined with lamivudine (LAM) in the treatment of LAM- resistant HBeAg- positive chronic hepatitis B (CHB) . Methods Forty patients with LAM- resistant HBeAg- positive CHB were randomly assigned to mon...

Efficacy of lamivudine and thymosin alpha-1 combination therapy in treatment of HBeAg-positive chronic hepatitis B: a meta-analysis

Qi YouTao, Zuo WeiZe

2014, 30(7): 639-643. DOI: 10.3969/j.issn.1001-5256.2014.07.016

Abstract(2556)

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Abstract:
Objective To evaluate the efficacy of lamivudine and thymosin alpha- 1 combination therapy in the treatment of HBeAg- positive chronic hepatitis B (CHB) by meta- analysis. Methods Randomized controlled trials (RCTs) of lamivudine and thymosin alpha- 1combination therapy in treatment of HBeAg- positi...

Original articles_Fatty Liver

Association of cholecystectomy with non-alcoholic fatty liver

Huang YaoBin, Li HuanMin, Li ChunGuang

2014, 30(7): 644-646. DOI: 10.3969/j.issn.1001-5256.2014.07.017

Abstract(2346)

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Abstract:

Objective To investigate the association of cholecystectomy with non- alcoholic fatty liver. Methods The 110 adults treated by cholecystectomy, who underwent physical examination in the Third Affiliated Hospital of Southern Medical University from January 2011to December 2013, were included in the s...

Original articles_Biliary diseases

Laparoscopic cholecystectomy for acute cholecystitis: clinical analysis of 216 cases

Dai JunTao, Zhang Ping, Wang Qing, Shen BoMing

2014, 30(7): 647-649. DOI: 10.3969/j.issn.1001-5256.2014.07.018

Abstract(2712)

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Abstract:
Objective To investigate the clinical experience of laparoscopic cholecystectomy (LC) for acute cholecystitis. Methods A retrospective analysis was performed on the clinical records of 216 patients with acute cholecystitis who underwent LC in Qingpu Branch of Zhongshan Hospital, Fudan University fro...

Experience in laparoscopic cholecystectomy for complicated gallbladder disease

Li XueYuan, Li Jian, Chen HongBing, Su QingHua, Wang Jian, Yang ShaoWei, Chen YaTing

2014, 30(7): 650-652. DOI: 10.3969/j.issn.1001-5256.2014.07.019

Abstract(2539)

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Abstract:
Objective To investigate the approach to laparoscopic cholecystectomy (LC) in the treatment of complicated gallbladder disease. Methods A retrospective analysis was performed on the clinical data of 81 patients with complicated gallbladder disease admitted to the Department of General Surgery in our...

Efficacy of duodenoscopic treatment of biliary ascariasis while preserving function of duodenal sphincter: a report of 69 cases

Liu Kai, Zhang Wei, Zhou Qiang, Liu SongYang, Li HuiMei, Liu YaHui

2014, 30(7): 653-655. DOI: 10.3969/j.issn.1001-5256.2014.07.020

Abstract(2652)

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Abstract:
Objective To observe the efficacy of duodenoscopic treatment of biliary ascariasis while preserving the function of the duodenal sphincter and to explore the feasibility of this technique as the preferred method for treatment of biliary ascariasis. Methods A retrospective analysis was performed on t...

Original articles_Liver neoplasms

Efficacy of antiviral therapy in hepatocellular carcinoma patients with high HBV DNA levels after radical resection

Ding Chen, Pan Fan, Hu HaiZhang, Xiong RiHui, Li Song, Jiang Yi, Pan Chen

2014, 30(7): 656-659. DOI: 10.3969/j.issn.1001-5256.2014.07.021

Abstract(2576)

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Abstract:

Objective To evaluate the efficacy of antiviral therapy in hepatocellular carcinoma (HCC) patients with high HBV DNA levels after radical resection. Methods A retrospective analysis was performed on the clinical data of 113 HCC patients with high HBV DNA levels who underwent radical resection from J...

Value of combined detection of serum AFP and GP73 in early diagnosis of hepatocellular carcinoma

Gao HaiFeng

2014, 30(7): 660-662. DOI: 10.3969/j.issn.1001-5256.2014.07.022

Abstract(2659)

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Abstract:

Objective To investigate the value of combined detection of serum alpha- fetoprotein (AFP) and Golgi protein- 73 (GP73) in the diagnosis of hepatocellular carcinoma (HCC) and to provide a basis for early diagnosis and differential diagnosis of HCC. Methods A total of 408 patients hospitalized in Bao...

Original articles_Others

Clinical features and related factors for Kawasaki disease with liver damage

Zhang HaiJun, Dong XiaoLei

2014, 30(7): 663-665. DOI: 10.3969/j.issn.1001-5256.2014.07.023

Abstract(2806)

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Abstract:

Objective To study the features of Kawasaki disease (KD) with liver damage and investigate the possible related factors, and to improve the understanding of liver damage in KD patients. Methods The clinical data of 75 KD patients admitted from 2008 to 2013 were collected to retrospectively analyze t...

Significance of serum cystatin C level for early diagnosis of acute kidney injury in patients with acute-on-chronic liver failure

Wan ZhiHong, Wang JianJun, Xie GuoMing, You ShaoLi, Liu HongLing, Zhu Bing, Zang Hong, Xin ShaoJie

2014, 30(7): 666-669. DOI: 10.3969/j.issn.1001-5256.2014.07.024

Abstract(2630)

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Abstract:

Objective To investigate the significance of serum cystatin C (CysC) level for the early diagnosis of acute kidney injury (AKI) in patients with acute- on- chronic liver failure (ACLF) . Methods Sixty patients with chronic hepatitis B- related ACLF and 60 patients with CHB, as well as 60 healthy con...

Clinical application of subclavian catheterization in severe hepatitis: a clinical analysis of 506 cases

Yang JingYi, Tang ZhenXiang, Ni Hui, Xian YongChao, Ye XiaoLing, Cheng ShuQuan

2014, 30(7): 670-673. DOI: 10.3969/j.issn.1001-5256.2014.07.025

Abstract(231)

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Abstract:

Objective To summarize the complications of subclavian catheterization in severe hepatitis patients and to investigate clinical safety and treatment. Methods Five hundred and six cases of severe hepatitis, who underwent subclavian catheterization before non- bioartificial liver operation like double...

Late-onset abnormal elevation of transaminase after hepatectomy indicates high risk of death

Yang LiJun, Liu Wei, Bi HuaQiang, Li XiaoWu, Bie Ping

2014, 30(7): 674-676. DOI: 10.3969/j.issn.1001-5256.2014.07.026

Abstract(3842)

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Abstract:

Objective To investigate the clinical significance of late- onset abnormal elevation of transaminase after hepatectomy. Methods A retrospective analysis was performed on the clinical data of 15 patients with abnormal elevation of transaminase after partial hepatectomy, who were admitted to our cente...

Case reports

Decompensated hepatitis B cirrhosis with atrial fibrillation: a report of one case

Ding ShenHua, Qian XueMei, Zhang Bin

2014, 30(7): 677-678. DOI: 10.3969/j.issn.1001-5256.2014.07.027

Abstract(2576)

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Abstract:

Suppurative cholecystitis after two times of esophageal variceal sclerotherapy: a report of one case

Liu Qin, Yang JianBo

2014, 30(7): 679-680. DOI: 10.3969/j.issn.1001-5256.2014.07.028

Abstract(2770)

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Abstract:

Li YaJun, Sun Li, Tian ZhenZhen, Xiu Ming, Gao RunPing

2014, 30(7): 681-682. DOI: 10.3969/j.issn.1001-5256.2014.07.029

Abstract(2612)

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Abstract:

Reviews

Research advances in liver cirrhosis complicated by bacteremia

Wang JingYun, Sun Jing, Gao YanHang

2014, 30(7): 683-686. DOI: 10.3969/j.issn.1001-5256.2014.07.030

Abstract(2547)

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Abstract:
Bacteremia is a common complication in patients with liver cirrhosis, and its incidence rises as the severity of liver disease increases. Liver cirrhosis complicated by bacteremia will lead to poor prognosis. The research progress in liver cirrhosis complicated by bacteremia is reviewed from the fol...

Role of transjugular intrahepatic portosystemic shunt in prevention and treatment of variceal bleeding in liver cirrhosis

Zheng LuanLuan, Han GuoHong, Fan DaiMing

2014, 30(7): 687-690. DOI: 10.3969/j.issn.1001-5256.2014.07.031

Abstract(2450)

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Abstract:
In patients with liver cirrhosis, variceal bleeding is a common fatal complication of portal hypertension. Varices are present in almost half of patients with cirrhosis at the time of diagnosis. Since transjugular intrahepatic portosystemic shunt (TIPS) was first applied clinically in 1988, the rele...

Research progress in noninvasive regression models for liver fibrosis in patients with chronic hepatitis B

Gu LiLi, Wang XianBo

2014, 30(7): 691-694. DOI: 10.3969/j.issn.1001-5256.2014.07.032

Abstract(2498)

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Abstract:
Objective and accurate assessment of liver fibrosis in patients with chronic hepatitis B (CHB) helps to choose the correct therapeutic scheme and guide the clinical treatment. In recent years, the noninvasive diagnostic models for liver fibrosis have been constantly emerging, but no consensus has be...

Research progress in EMT and fibrosis of hepatobiliary system

Ceng ShuaiDan, Liu Lei

2014, 30(7): 695-699. DOI: 10.3969/j.issn.1001-5256.2014.07.033

Abstract(2610)

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Abstract:
Epithelial- mesenchymal transition (EMT) , which means the transformation of epithelial cells into mesenchymal cells under the influence of cytokines, leading to pathological changes in tissues. According to recent research findings, EMT plays an important role in organ fibrosis. Various types of EM...

Studies on PPAR α and γ participating in progression of liver fibrosis by regulating ACSL1

Xin Xuan, Yan HongZhu, Li WeiQing, Yu HongYu

2014, 30(7): 700-702. DOI: 10.3969/j.issn.1001-5256.2014.07.034

Abstract(2758)

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Abstract:
During the development and procession of liver fibrosis, peroxisome proliferator- activated receptor (PPAR) α and γ are in charge of the regulation of lipid metabolism, fatty acid metabolism, anti- liver fibrosis, etc., and are closely related to fat metabolism- related enzymes. As a key enzyme in f...

Advances in diagnosis and treatment of portal hypertensive biliopathy

Weng NingNa, Li Xiao

2014, 30(7): 703-705. DOI: 10.3969/j.issn.1001-5256.2014.07.035

Abstract(2755)

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Abstract:
With the progress in research on portal hypertension in recent years, portal hypertensive biliopathy (PHB) has attracted more and more attention. The pathophysiology and clinical manifestations of PHB, as well as the main methods for the diagnosis and treatment of this disease, are briefly described...

Conference overviews

Summary of the 2014 Sino-America symposium on drug-induced liver injury and Chinese HepaTox press release conference

Yu LeCheng

2014, 30(7): 706-707. DOI: 10.3969/j.issn.1001-5256.2014.07.036

Abstract(1780)

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Abstract: