中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 10
Oct.  2014
Turn off MathJax
Article Contents

Research progress in prognostic markers of acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2014.10.026
Research funding:

 

  • Received Date: 2014-03-25
  • Published Date: 2014-10-20
  • Acute-on-chronic liver failure ( ACLF) is a clinical entity encompassing an acute deterioration of liver function and failure of one or more organs, which results in high short-term mortality rate. In recent years, a number of novel prognostic markers of ACLF have emerged and provided a basis for the treatment and prognostic evaluation of ACLF. Researches on both commonly used and novel makers for prognosis of ACLF are reviewed in order to improve the existing prognostic evaluation system and to provide a basis for the treatment and prognostic evaluation of ACLF.

     

  • loading
  • [1]SARIN SK, KUMAR A, ALMEIDA JA, et al.Acute-on-chronic liver failure:consensus recommendations of the Asian Pacific Association for the study of the liver (APASL) [J].Hepatol Int, 2009, 3 (1) :269-282.
    [2]LIU M, ZHANG XQ, MAO Q.Features of acute-on-chronic preliver failure and establishment of a predictive model for risk of acuteon-chronic liver failure[J].J Clin Hepatol, 2012, 28 (10) :732-734. (in Chinese) 刘明, 张绪清, 毛青.慢加急性肝衰竭前期的概念及预警模型[J].临床肝胆病杂志, 2012, 28 (10) :732-734.
    [3]HE WP, HU JH, ZHAO J, et al.Comparison of four prognostic models and a new Logistic regression model to predict short-term prognosis of acute-on-chronic hepatitis B liver failure[J].Chin Med J (Engl) , 2012, 125 (13) :2272-2278.
    [4]XIA Q, DAI X, ZHANG Y, et al.A modified MELD model for Chinese pre-ACLF and ACLF patients and it reveals poor prognosis in pre-ACLF patients[J].PLoS One, 2013, 8 (6) :e64379.
    [5]ZHENG MH, SHI KQ, LIN XF, et al.A model to predict 3-month mortality risk of acute-on-chronic hepatitis B liver failure using artificial neural network[J].J Viral Hepat, 2013, 20 (4) :248-255.
    [6]DUSEJA A, CHOUDHARY NS, GUPTA S, et al.APACHE II score is superior to SOFA, CTP and MELD in predicting the short-term mortality in patients with acute-on-chronic liver failure (ACLF) [J].J Dig Dis, 2013, 14 (9) :484-490.
    [7]CHOLONGITAS E, THEOCHARIDOU E, VASIANOPOULOU P, et al.Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure[J].Liver Transpl, 2012, 18 (4) :405-412.
    [8]MOREAU R, JALAN R, GINES P, et al.Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis[J].Gastroenterology, 2013, 144 (7) :1426-1437.
    [9]THEOCHARIDOU E, PIERI G, MOHAMMAD AO, et al.The Royal Free Hospital Score:a calibrated prognostic model for patients with cirrhosis admitted to intensive care unit.Comparison with current models and CLIF-SOFA Score[J].Am J Gastroenterol, 2014, 109 (4) :554-562.
    [10]PAN XF, ZHANG K, YANG XA, et al.Interleukin-21 expression in serum of patients with acute-on-chronic liver failure and its significance[J].Chin J Exp Clin Virol, 2012, 26 (6) :477-479. (in Chinese) 潘兴飞, 张卡, 杨小安, 等.慢加急性肝衰竭患者外周血IL-21水平检测及其意义[J].中华实验和临床病毒学杂志, 2012, 26 (6) :477-479.
    [11]WANG LY, FAN YC, ZHAO J, et al.Elevated expression of tumour necrosis factor-alpha-induced protein 8 (TNFAIP8) -like 2 mRNA in peripheral blood mononuclear cells is associated with disease progression of acute-on-chronic hepatitis B liver failure[J].J Viral Hepat, 2014, 21 (1) :64-73.
    [12]YE H, WANG LY, ZHAO J, et al.Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure[J].World J Gastroenterol, 2013, 19 (18) :2818-2825.
    [13]WANG P, XU B, ZHANG LJ.Changes and clinical significances of Treg and Th17 cells in the peripheral blood of patients with different types of hepatitis B virus infection[J].Chin J Immunol, 2013, 29 (6) :618-624. (in Chinese) 王萍, 胥冰, 张丽君.不同类型HBV感染者外周血Treg/Th17细胞的变化及意义[J].中国免疫学杂志, 2013, 29 (6) :618-624.
    [14]ZHANG GL, XIE DY, LIN BL, et al.Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure[J].J Gastroenterol Hepatol, 2013, 28 (3) :513-521.
    [15]NIU YH, YIN DL, LIU HL, et al.Restoring the Treg cell to Th17cell ratio may alleviate HBV-related acute-on-chronic liver failure[J].World J Gastroenterol, 2013, 19 (26) :4146-4154.
    [16]SHI F, ZHANG JY, ZENG Z, et al.Skewed ratios between CD3+T cells and monocytes are associated with poor prognosis in patients with HBV-related acute-on-chronic liver failure[J].Biochem Biophys Res Commun, 2010, 402 (1) :30-36.
    [17] LIU XY, SHI F, ZHAO H, et al.Research of PD-1 expression in CD8+T cell of Peripheral blood with HBV-associated acute-onchronic liver failure[J].Chin J Exp Clin Virol, 2010, 24 (2) :125-127. (in Chinese) 刘晓燕, 石峰, 赵鸿, 等.PD-1受体在HBV-ACLF患者外周血CD8+T细胞上的表达研究[J].中华实验和临床病毒学杂志, 2010, 24 (2) :125-127.
    [18]CAO D, XU H, GUO G, et al.Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-onchronic liver failure[J].Inflammation, 2013, 36 (1) :110-120.
    [19]SHI WJ, WEI L, TIAN PF, et al.Serum levels of Th1/Th2 cytokines in HBV-related acute-on-chronic liver failure patients[J].Chin Hepatol, 2013, 18 (1) :27-29. (in Chinese) 施文娟, 魏丽, 田鹏飞, 等.HBV相关慢加急性肝衰竭患者血清Th1/Th2型细胞因子水平的研究[J].肝脏, 2013, 18 (1) :27-29.
    [20]CHEN R, HOU W, ZHANG Q, et al.Emerging role of highmobility group box 1 (HMGB1) in liver diseases[J].Mol Med, 2013, 19 (11) :357-366.
    [21]DUAN XZ, HU JH, LI C, et al.Relation between serum levels of high mobility group box 1 and hepatitis B virus-related acute-on-chronic liver failure[J].Chin J Hepatol, 2013, 21 (6) :434-437. (in Chinese) 段学章, 胡瑾华, 李晨, 等.血清高迁移率族蛋白1在乙型肝炎病毒相关慢加急性肝衰竭患者中的特点及其临床意义[J].中华肝脏病杂志, 2013, 21 (6) :434-437.
    [22]LI X, WANG LK, WANG LW, et al.Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats[J].Inflamm Res, 2013, 62 (7) :703-709.
    [23]OETTL K, BIRNER-GRUENBERGER R, SPINDELBOECK W, et al.Oxidative albumin damage in chronic liver failure:relation to albumin binding capacity, liver dysfunction and survival[J].J Hepatol, 2013, 59 (5) :978-983.
    [24]LIU H, HAN T, TIAN J, et al.Monitoring oxidative stress in acute-on-chronic liver failure by advanced oxidation protein products[J].Hepatol Res, 2012, 42 (2) :171-180.
    [25]ELFIMOVA N, SCHLATTJAN M, SOWA JP, et al.Circulating microRNAs:promising candidates serving as novel biomarkers of acute hepatitis[J].Front Physiol, 2012, 3 (12) :476.
    [26]YU DS, AN FM, GONG BD, et al.The regulatory role of microRNA-1187 in TNF-alpha-mediated hepatocyte apoptosis in acute liver failure[J].Int J Mol Med, 2012, 29 (4) :663-668.
    [27]NG R, SONG G, ROLL GR, et al.A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration[J].J Clin Invest, 2012, 122 (3) :1097-1108.
    [28]YUAN Q, LOYA K, RANI B, et al.MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration[J].Hepatology, 2013, 57 (1) :299-310.
    [29]YU ZY, BAI YN, LUO LX, et al.Expression of microRNA-150targeting vascular endothelial growth factor-A is downregulated under hypoxia during liver regeneration[J].Mol Med Rep, 2013, 8 (1) :287-293.
    [30]DAI XH, ZHANG P, XIAO MF, et al.Protective role ofα2HS-glycoprotein in HBV-associated liver failure[J].Int J Mol Sci, 2011, 12 (6) :3846-3856.
    [31]PENG L, LIU J, LI YM, et al.Serum proteomics analysis and comparisons using iTRAQ in the progression of hepatitis B[J].Exp Ther Med, 2013, 6 (5) :1169-1176.
    [32]HAN T, LIU Y, LIU H, et al.Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure[J].World J Gastroenterol, 2010, 16 (5) :625-630.
    [33]REN F, CHEN Y, WANG Y, et al.Comparative serum proteomic analysis of patients with acute-on-chronic liver failure:alpha-1-acid glycoprotein maybe a candidate marker for prognosis of hepatitis B virus infection[J].J Viral Hepat, 2010, 17 (11) :816-824.
    [34]WEN T, GOU CY, LU J, et al.Changes of extracellular histones in mice with acute liver failure and its therapeutic potential[J].Chin J Emerg Med, 2013, 22 (2) :148-152. (in Chinese) 温韬, 勾春燕, 卢静, 等.细胞外组蛋白在急性肝衰竭小鼠中的变化[J].中华急诊医学杂志, 2013, 22 (2) :148-152.
    [35]MAO Y, HUANG X, YU K, et al.Metabonomic analysis of hepatitis B virus-induced liver failure:identification of potential diagnostic biomarkers by fuzzy support vector machine[J].J Zhejiang Univ Sci B, 2008, 9 (6) :474-481.
    [36]NIE CY, HAN T, ZHANG L, et al.Cross-sectional and dynamic change of serum metabolite profiling for Hepatitis B-related acute-on-chronic liver failure by UPLC/MS[J].J Viral Hepat, 2014, 21 (1) :53-63.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2620) PDF downloads(1301) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return