2014 No. 10

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Editorial

The definition and natural history of severe exacerbation of hepatitis B

Guo Wei, Li WeiNa, Ning Qin

2014, 30(10): 967-969. DOI: 10.3969/j.issn.1001-5256.2014.10.001

Abstract(2373)

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Abstract:

Despite different opinions on its definition and classification in the past, a consensus has gradually been reached regarding the naming, classification, and clinical diagnosis of liver failure. The classification of liver failure is described, and the definition and natural history of severe exacer...

Therapeutic guidelines

Chinese consensus on pancreatic cancer diagnosis and treatment (2014 version)

The Chinese Society of Clinical Oncology Pancreatic Cancer Expert Committee;

2014, 30(10): 970-980. DOI: 10.3969/j.issn.1001-5256.2014.10.002

Abstract(267)

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Discussions by experts

Cytokine storm and liver failure

Chen Zhi, Zhu HaiHong, Yang Ying

2014, 30(10): 981-983. DOI: 10.3969/j.issn.1001-5256.2014.10.003

Abstract(3402)

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Abstract:
Cytokine storm plays an important role in the pathogenesis of liver failure. It is closely related to hepatocyte necrosis in the clinical course and the prognosis of this disease. With Kupffer cells as a clue, it is elucidated that related cells and cytokines influence each other and jointly functio...

Immune-mediated liver failure

Wang XiaoJing, Zhang XiaoPing, Ning Qin

2014, 30(10): 984-991. DOI: 10.3969/j.issn.1001-5256.2014.10.004

Abstract(3193)

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Abstract:
The primary causative factors of liver failure include direct damage and immune-mediated liver injury. Increasing evidence suggests that immune-mediated injury plays a pivotal role in the pathogenesis of liver failure. The new concepts concerning the mechanisms of immune-mediated liver injury in liv...

Original articles_Liver failure

Logistic regression analysis of prognostic factors in 106 acute-on-chronic liver failure patients with hepatic encephalopathy

Cui YanPing, Liu FengHua, Shi QingFeng, Zhao HongKui, Wang SiKui

2014, 30(10): 992-995. DOI: 10.3969/j.issn.1001-5256.2014.10.005

Abstract(3005)

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Abstract:

Objective To analyze the prognostic factors in acute-on-chronic liver failure ( ACLF) patients with hepatic encephalopathy ( HE) and to explore the risk factors for prognosis. Methods A retrospective analysis was performed on106 ACLF patients with HE who were hospitalized in our hospital from Januar...

A simple scoring system for evaluating severity of HBV-related acute-on-chronic liver failure

Li XinYan, Huang ShuLin, Fang Liang, Lei RuiXiang, Ke WeiMin

2014, 30(10): 996-999. DOI: 10.3969/j.issn.1001-5256.2014.10.006

Abstract(2910)

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Abstract:

Objective To establish a simple scoring system for evaluating the severity of hepatitis B virus ( HBV) -related acute-on-chronic liver failure ( HBV-ACLF) . Methods A retrospective analysis was performed on the clinical data of 620 patients with HBV-ACLF who were divided into group I ( 500 patients)...

Predictive value of Glasgow Prognostic Score system for mortality in patients with acute-on-chronic liver failure associated with hepatitis B

Li ShaoJun, Cheng JiaXi, Lu XiaoBo, Zhang LiJuan, Zhang YueXin

2014, 30(10): 1000-1004. DOI: 10.3969/j.issn.1001-5256.2014.10.007

Abstract(3320)

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Abstract:

Objective To assess the predictive value of Glasgow Prognostic Score ( GPS) system for mortality in patients with acute-on-chronic liver failure associated with hepatitis B ( HBV-ACLF) . Methods The clinical data of 437 patients who were diagnosed with HBV-ACLF and admitted to the Department of Infe...

Association of ERα gene polymorphism at position 29 with HBV-related acute-on-chronic liver failure

Zhou Ning, Zhang YueRong, Wei ShiFang, Wu LiYang, Li XiangLin, Sun MeiYing

2014, 30(10): 1005-1008. DOI: 10.3969/j.issn.1001-5256.2014.10.008

Abstract(2878)

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Abstract:

Objective To investigate the relationship between estrogen receptor alpha ( ERα) gene polymorphism at position 29 and hepatitis B virus ( HBV) -related acute-on-chronic liver failure ( HBV-ACLF) and the genetic pathogenesis of HBV-ACLF. Methods A total of 61HBV-ACLF patients, 79 patients with chroni...

Meta-analysis of risk factors for posthepatectomy liver failure in patients with hepatocellular carcinoma

Yin TianSheng, Yi YaYang, Mao XiXian, Li DeWei

2014, 30(10): 1009-1014. DOI: 10.3969/j.issn.1001-5256.2014.10.009

Abstract(3220)

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Abstract:

Objective To investigate the risk factors for posthepatectomy liver failure ( PHLF) in patients with hepatocellular carcinoma ( HCC) and to provide a theoretical basis for the prediction and prevention of PHLF. Methods A meta-analysis was performed on the studies on risk factors for PHLF in HCC pati...

Clinical efficacy of plasma exchange therapy in treatment of liver failure

Zhang Lin, Zhao ShouSong

2014, 30(10): 1015-1019. DOI: 10.3969/j.issn.1001-5256.2014.10.010

Abstract(3211)

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Abstract:

Objective To investigate the clinical efficacy of plasma exchange ( PE) in the treatment of liver failure. Methods A retrospective analysis was performed on the clinical data of patients with liver failure who were treated from January 2012 to June 2013 in our hospital. Thirty-three patients in PE g...

Clinical effect of artificial liver support system on serum hs-CRP level in patients with hepatic failure

Dong DanDan, Yan YouQin

2014, 30(10): 1020-1022. DOI: 10.3969/j.issn.1001-5256.2014.10.011

Abstract(2374)

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Objective To evaluate the clinical effect of artificial liver support system ( ALSS) on serum high-sensitivity C-reactive protein ( hs-CRP) level and investigate the influence of the change in hs-CRP level on clinical prognosis among patients with hepatic failure.Methods Patients were recruited into...

Changes in distribution of cholinergic and nitrergic nerves in antrum of rats with liver failure

Zhu JinZhao, Rao JunWei, Lu: Yong, Li Huan

2014, 30(10): 1023-1026. DOI: 10.3969/j.issn.1001-5256.2014.10.012

Abstract(2244)

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Abstract:

Objective To observe the changes in gastric emptying and distribution of cholinergic and nitrergic nerves in the myenteric plexus of the antrum of rats with liver failure. Methods Forty Wistar rats were randomly divided into control group and liver failure model group. The gastric emptying of rats w...

Functional study on two artificial liver bioreactors with collagen gel

Xu Bing, Wu LinLan, Wei JianWei, Huang SuQin, Chen Yi, Zhao ZhiPing, Jiang XiaoZhi, Zheng DengZi, Yang MeiYu

2014, 30(10): 1027-1030. DOI: 10.3969/j.issn.1001-5256.2014.10.013

Abstract(2244)

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Objective To improve the hollow fiber bioreactor of artificial liver. Methods Rat hepatocytes mixed with collagen solution were injected into the external cavity of a hollow fiber reactor to construct a bioreactor of hepatocytes suspended in collagen gel ( group Ⅰ) .Other rat hepatocytes suspended i...

Original articles_Viral hepatitis

Clinical efficacy of combined treatment with entecavir and adefovir dipivoxil for lamivudine-resistant chronic hepatitis B

Bao Jun, Liang JunCai, Gong Li, Chen XiaoXiao

2014, 30(10): 1031-1034. DOI: 10.3969/j.issn.1001-5256.2014.10.014

Abstract(3690)

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Abstract:

Objective To evaluate the efficacy and safety of the combined therapy with entecavir ( ETV) and adefovir dipivoxil ( ADV) in patients with lamivudine ( LAM) -resistant chronic hepatitis B ( CHB) . Methods A total of 45 patients who were diagnosed with LAM-resistant CHB and admitted to the Kunshan Pe...

Zhang Ying, Jia JiDong

2014, 30(10): 1035-1038. DOI: 10.3969/j.issn.1001-5256.2014.10.015

Abstract(2818)

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Abstract:
Objective To investigate the changes in serum leptin and adiponectin levels and their significance in patients with chronic hepatitis B virus ( HBV) infection. Methods One hundred and twenty-five patients with chronic HBV infection ( 44 HBeAg-positive cases, 31 HBeAg-negative cases of chronic hepati...

HBV genotype distribution and its relationship with serum HBV DNA level and HBeAg expression among patients with chronic hepatitis B in southern Zhejiang Province, China

Zhou LianLian, Shen Mo, Zhou Ping, Zhou Wu, Lin XiangYang

2014, 30(10): 1039-1041. DOI: 10.3969/j.issn.1001-5256.2014.10.016

Abstract(2831)

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Abstract:
Objective To analyze the hepatitis B virus ( HBV) genotype distribution among chronic hepatitis B patients in southern Zhejiang Province, China, and to explore the relationship of HBV genotype with serum HBV DNA level and HBeAg expression. Methods Serum samples were collected from 161 patients posit...

Evaluation and selection of indirect ELISA and sandwich ELISA kits for anti-HCV detection

Li YongZhen, Zhen ZhiJun

2014, 30(10): 1042-1044. DOI: 10.3969/j.issn.1001-5256.2014.10.017

Abstract(3166)

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Abstract:
Objective To compare the sensitivity and specificity between indirect enzyme-linked immunosorbent assay ( ELISA) and double-antibody sandwich ELISA kits produced in China and to select the best ELISA kit. Methods Samples for evaluation included 60 serum plates and 40 serum samples positive or weakly...

Original articles_Liver fibrosis and liver cirrhosis

A comparative study of FibroScan and B ultrasound in diagnosis of liver fibrosis

Liu LingFeng, Lu HaiYing, Yu YanYan, Wu ChiHong, Tian XiuLan

2014, 30(10): 1045-1049. DOI: 10.3969/j.issn.1001-5256.2014.10.018

Abstract(3650)

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Abstract:

Objective To compare the diagnostic performances of FibroScan ( FS) and B ultrasound for liver fibrosis and assess the relationship between the two methods. Methods The clinical data of 432 patients who were admitted to our institution between October 2012 and February 2014 were retrospectively anal...

Strengthening self-management improves treatment compliance and outcome in hepatitis B patients with decompensated cirrhosis treated with entecavir

Cui YuHua, Wei XiaoJuan, Lin HuiMei

2014, 30(10): 1050-1052. DOI: 10.3969/j.issn.1001-5256.2014.10.019

Abstract(2855)

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Abstract:
Objective To investigate the effect of strengthening self-management on the treatment compliance and outcome in hepatitis B patients with decompensated cirrhosis treated with entecavir. Methods A total of 120 hepatitis B patients with decompensated cirrhosis, who received antiviral therapy with ente...

Proteome analysis of liver nonparenchymal cells from rats with alcoholic liver fibrosis

Zhang LiJun, Jia XiaoFang, Wu DaGe, Liu XiaoQian, Huang Yan, Zhang JiaoLi, Cheng NengNeng

2014, 30(10): 1053-1059. DOI: 10.3969/j.issn.1001-5256.2014.10.020

Abstract(2591)

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Abstract:
Objective The development of alcoholic liver fibrosis ( ALF) is a complex process involving both parenchymal and nonparenchymal cells. The knowledge about the proteome of liver nonparenchymal cells ( NPCs) in response to ethanol is limited. This paper aims to investigate the regulatory effect of alc...

Original articles_Hepatopancreatobiliary tumor

Application of hepatectomy without hepatic blood flow occlusion in treatment of primary liver cancer

Chen Kai, Qiu FuNan, Tian YiFeng, Lai ZhiDe, Zhou SongQiang, Yan MaoLin, Wang YaoDong

2014, 30(10): 1060-1063. DOI: 10.3969/j.issn.1001-5256.2014.10.021

Abstract(2741)

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Abstract:

Objective To investigate the effects of hepatectomy without hepatic blood flow occlusion ( HBFO) on the liver function and postoperative recovery in patients with primary liver cancer. Methods Eighty patients with primary liver cancer who underwent hepatectomy in our hospital from June 2010 to June ...

Values of serum AFP, GGTⅡ and GP73 in diagnosis of primary hepatocellular carcinoma

Zhu Chen, Sun YuanYuan, Jin Yan

2014, 30(10): 1064-1066. DOI: 10.3969/j.issn.1001-5256.2014.10.022

Abstract(2927)

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Abstract:

Objective To explore the early diagnostic values of serum alpha-fetoprotein ( AFP) , gamma-glutamyltransferase Ⅱ ( GGTⅡ) , and Golgi protein 73 ( GP73) in patients with primary hepatocellular carcinoma ( PHC) . Methods The serum specimens of 100 patients with liver diseases ( 50 cases of hepatitis a...

Original articles_Others

Clinical efficacy of puerarin combined with compound ammonium glycyrrhetate S in treatment of alcoholic hepatitis

Ji HuiChun, Liu QingDe, Wang HongQi, Li Juan, Zhu Yun, Sun Yang, Zhou ZhongHai, Liu JunQuan

2014, 30(10): 1067-1070. DOI: 10.3969/j.issn.1001-5256.2014.10.023

Abstract(2650)

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Abstract:

Objective To investigate the clinical efficacy of puerarin combined with compound ammonium glycyrrhetate S in the treatment of alcoholic hepatitis. Methods A total of 92 patients with alcoholic hepatitis who were admitted to our hospital from February 2011 to February 2014 were recruited in this stu...

Anxiety in mice with acute hepatic encephalopathy induced by thioacetamide

Chen QiMing, Yuan Hong, Dai LiRong, Jiang Ni, Ren WenTing, Chen QingFeng

2014, 30(10): 1071-1075. DOI: 10.3969/j.issn.1001-5256.2014.10.024

Abstract(3040)

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Abstract:

Objective To evaluate the mental disorders in mice with thioacetamide ( TAA) -induced acute hepatic encephalopathy ( AHE) .Methods Thirty male Kunming mice were equally and randomly divided into two groups ( treatment group and control group) . Mice in the treatment group received an intraperitoneal...

Case reports

One case of hepatomegaly due to primary hepatic amyloidosis accompanied by hyperuricemia

Tang ShanHong, Cheng ShuangPing, Qin JianPing, Wu XiaoLing, Chen YiHua, Liang Yan, Ceng WeiZheng, Jiang MingDe

2014, 30(10): 1076-1077. DOI: 10.3969/j.issn.1001-5256.2014.10.025

Abstract(2078)

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Abstract:

Reviews

Research progress in prognostic markers of acute-on-chronic liver failure

Zhang YuLing, Han Tao, Zhang Min, Zhang Qian

2014, 30(10): 1078-1081. DOI: 10.3969/j.issn.1001-5256.2014.10.026

Abstract(2669)

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Abstract:
Acute-on-chronic liver failure ( ACLF) is a clinical entity encompassing an acute deterioration of liver function and failure of one or more organs, which results in high short-term mortality rate. In recent years, a number of novel prognostic markers of ACLF have emerged and provided a basis for th...

Analysis of prognostic models for liver failure

Liu JieYu, Feng YiChao

2014, 30(10): 1082-1086. DOI: 10.3969/j.issn.1001-5256.2014.10.027

Abstract(2769)

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Abstract:

Liver failure progresses rapidly, and patients with this disease are usually in a critical condition. The medical treatment of liver failure has unsatisfactory results, leading to a high mortality. How to accurately judge the prognosis of patients with liver failure according to their clinical manif...

Research advances in associations between IL28B polymorphisms and chronic hepatitis B /C virus infection

Shen WenJuan, Ha MingHao

2014, 30(10): 1087-1090. DOI: 10.3969/j.issn.1001-5256.2014.10.028

Abstract(2664)

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Abstract:
Chronic infection with hepatitis B/C virus ( HBV/HCV) is a widespread epidemic in China. The single nucleotide polymorphisms ( SNPs) in interleukin 28B ( IL28B) gene have been associated with chronic HBV/HCV infection and response to interferon therapy. The biological functions and characteristics o...

Research advances in serum biomarkers for early diagnosis of hepatocellular carcinoma

Zhu MingYu, Chen Jie, Zhang XinXin

2014, 30(10): 1091-1093. DOI: 10.3969/j.issn.1001-5256.2014.10.029

Abstract(2729)

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Abstract:
Hepatocellular carcinoma ( HCC) is a disease with high incidence and mortality and has become a serious threat to human health.So far, none of the available markers can be used alone for early diagnosis of HCC. Recently identified serum markers with potential clinical value for early diagnosis of HC...

Treatment of minimal hepatic encephalopathy

Zhao Kai, Zhang YueXin

2014, 30(10): 1094-1096. DOI: 10.3969/j.issn.1001-5256.2014.10.030

Abstract(2812)

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Abstract:
Minimal hepatic encephalopathy ( MHE) is defined as early hepatic encephalopathy without grossly evident neurologic abnormalities, but with cognitive deficits that can be revealed by psychometric testing. However, numerous studies have shown a lack of obvious clinical manifestations in MHE patients,...