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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2014
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Article Contents

Recent advances in pathogenesis and management of pruritus in cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2014.11.031
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  • Received Date: 2014-01-28
  • Published Date: 2014-11-20
  • Pruritus is one of the common clinical manifestations of cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis, and intrahepatic cholestasis of pregnancy. Potential incentives of itching include bile salts, histamine, progesterone metabolites, endogenous opioid substances, and lysophosphatidic acid, according to previous studies. However, the exact pathogenesis of cholestatic pruritus remains unclear, and the current treatment can only alleviate the symptoms in some of the patients. Novel methods for treating pruritus have been proposed and /or are being studied. The recent experimental and clinical studies on the pathogenesis and treatment of pruritus in cholestatic hepatitis are reviewed, in order to improve the understanding and management of cholestatic pruritus.

     

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