|
[1]KAWANO Y, COHEN DE.Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease[J].J Gastroenterol, 2013, 48 (4) :434-441.
|
|
[2]YOUNOSSI ZM, REYES MJ, MISHRA A, et al.Systematic review with meta‐analysis:non‐alcoholic steatohepatitis‐a case for personalised treatment based on pathogenic targets[J].Aliment pharmacol Ther, 2014, 39 (1) :3-14.
|
|
[3]HOTAMISLIGIL GS.Endoplasmic reticulum stress and the inflammatory basis of metabolic disease[J].Cell, 2010, 140 (6) :900-917.
|
|
[4]FU S, YANG L, LI P, et al.Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity[J].Nature, 2011, 473 (7348) :528-531.
|
|
[5]OZCAN L, TABAS I.Role of endoplasmic reticulum stress in metabolic disease and other disorders[J].Annu Rev Med, 2012, 63:317-328.
|
|
[6]ZHANG XQ, XU CF, YU CH, et al.Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease[J].World J Gastroenterol, 2014, 20 (7) :1768-1776.
|
|
[7]HETZ C, CHEVET E, HARDING HP.Targeting the unfolded protein response in disease[J].Nat Rev Drug Discov, 2013, 12 (9) :703-719.
|
|
[8]CHO H, WU M, ZHANG L, et al.Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells[J].BMC Syst Biol, 2013, 7 (1) :9.
|
|
[9]WU S, TAN M, HU Y, et al.Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis[J].J Biol Chem, 2004, 279 (33) :34898-34902.
|
|
[10]LI Y, XU S, GILES A, et al.Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver[J].FASEB J, 2011, 25 (5) :1664-1679.
|
|
[11]LOGUE SE, CLEARY P, SAVELJEVA S, et al.New directions in ER stress-induced cell death[J].Apoptosis, 2013, 18 (5) :537-546.
|
|
[12]MALHI H, KAUFMAN RJ.Endoplasmic reticulum stress in liver disease[J].J Hepatol, 2011, 54 (4) :795-809.
|
|
[13]XU C, BAILLY-MAITRE B, REED JC.Endoplasmic reticulum stress:cell life and death decisions[J].J Clin Invest, 2005, 115 (10) :2656-2664.
|
|
[14]KIM I, XU W, REED JC.Cell death and endoplasmic reticulum stress:disease relevance and therapeutic opportunities[J].Nat Rev Drug Discov, 2008, 7 (12) :1013-1030.
|
|
[15] HOTAMISLIGIL GS.Endoplasmic reticulum stress and the inflammatory basis of metabolic disease[J].Cell, 2010, 140 (6) :900-917.
|
|
[16]SHORE GC, PAPA FR, OAKES SA.Signaling cell death from the endoplasmic reticulum stress response[J].Curr Opin Cell Biol, 2011, 23 (2) :143-149.
|
|
[17]FABBRINI E, SULLIVAN S, KLEIN S.Obesity and nonalcoholic fatty liver disease:biochemical, metabolic, and clinical implications[J].Hepatology, 2010, 51 (2) :679-689.
|
|
[18]WANG S, CHEN Z, LAM V, et al.IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis[J].Cell Metab, 2012, 16 (4) :473-486.
|
|
[19] LEE AH, SCAPA EF, COHEN DE, et al.Regulation of hepatic lipogenesis by the transcription factor XBP1[J].Science, 2008, 320 (5882) :1492-1496.
|
|
[20]SO JS, HUR KY, TARRIO M, et al.Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice[J].Cell Metab, 2012, 16 (4) :487-499.
|
|
[21] BOBROVNIKOVA-MARJON E, HATZIVASSILIOU G, GRIGORIADOU C, et al.PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation[J].Proc Natl Acad Sci U S A, 2008, 105 (42) :16314-16319.
|
|
[22]LI H, MENG Q, XIAO F, et al.ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis[J].Biochem J, 2011, 438 (2) :283-289.
|
|
[23]OYADOMARI S, HARDING HP, ZHANG Y, et al.Dephosphorylation of translation initiation factor 2αenhances glucose tolerance and attenuates hepatosteatosis in mice[J].Cell Metab, 2008, 7 (6) :520-532.
|
|
[24]ZENG L, LU M, MORI K, et al.ATF6 modulates SREBP2-mediated lipogenesis[J].EMBO J, 2004, 23 (4) :950-958.
|
|
[25]HAN J, MURTHY R, WOOD B, et al.ER stress signalling through eIF2αand CHOP, but not IRE1α, attenuates adipogenesis in mice[J].Diabetologia, 2013, 56 (4) :911-924.
|
|
[26]RUTKOWSKI DT, WU J, BACK SH, et al.UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators[J].Dev Cell, 2008, 15 (6) :829-840.
|
|
[27]JOHNSON GL, NAKAMURA K.The c-jun kinase/stress-activated pathway:regulation, function and role in human disease[J].Biochim Biophys Acta, 2007, 1773 (8) :1341-1348.
|
|
[28]IBRAHIM SH, GORES GJ.Who pulls the trigger:JNK activation in liver lipotoxicity?[J].J Hepatol, 2012, 56 (1) :17-19.
|
|
[29]KODAMA Y, KISSELEVA T, IWAISAKO K, et al.c-Jun Nterminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice[J].Gastroenterology, 2009, 137 (4) :1467-1477.
|
|
[30]SRIVASTAVA RK, SOLLOTT SJ, KHAN L, et al.Bcl-2 and Bcl-XL block thapsigargin-induced nitric oxide generation, c-Jun NH2-terminal kinase activity, and apoptosis[J].Mol Cell Biol, 1999, 19 (8) :5659-5674.
|
|
[31]URANO F, WANG X, BERTOLOTTI A, et al.Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1[J].Science, 2000, 287 (5453) :664-666.
|
|
[32]RIBEIRO PS, CORTEZ-PINTO H, SOLS, et al.Hepatocyte apoptosis, expression of death receptors, and activation of NFkappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients[J].Am J Gastroenterol, 2004, 99 (9) :1708-1717.
|
|
[33]HE G, KARIN M.NF-κB and STAT3–key players in liver inflammation and cancer[J].Cell Res, 2011, 21 (1) :159-168.
|
|
[34]COHEN JC, HORTON JD, HOBBS HH.Human fatty liver disease:old questions and new insights[J].Science, 2011, 332 (6037) :1519-1523.
|
|
[35]DARA L, JI C, KAPLOWITZ N.The contribution of endoplasmic reticulum stress to liver diseases[J].Hepatology, 2011, 53 (5) :1752-1763.
|
|
[36]PUTHALAKATH H, O'REILLY L A, GUNN P, et al.ER stress triggers apoptosis by activating BH3-only protein Bim[J].Cell, 2007, 129 (7) :1337-1349.
|
|
[37]JI C, MEHRIAN-SHAI R, CHAN C, et al.Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding[J].Alcohol Clin Exp Res, 2005, 29 (8) :1496-1503.
|
|
[38]CAO J, DAI DL, YAO L, et al.Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway[J].Mol Cell Biochem, 2012, 364 (1-2) :115-129.
|
|
[39]KODAMA T, HIKITA H, KAWAGUCHI T, et al.The Bcl-2 homology domain 3 (BH3) -only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver[J].J Biol Chem, 2013, 288 (42) :30009-30018.
|
|
[40]LEI K, DAVIS RJ.JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis[J].Proc Natl Acad Sci U S A, 2003, 100 (5) :2432-2437.
|
|
[41]PANASIUK A, DZIECIOL J, PANASIUK B, et al.Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease[J].World J Gastroenterol, 2006, 12 (38) :6198-6202.
|
|
[42]LIU J, LI WP, SHI JM, et al.Endoplasmic reticulum stress participated in fatty degeneration induced by free fatty acids in vitro hepatic steatosis model[J].J Med Res, 2012, 41 (12) :122-125. (in Chinese) 刘江, 李伟平, 施杰民, 等.内质网应激参与细胞脂肪变性的研究[J].医学研究杂志, 2012, 41 (12) :122-125.
|
|
[43]WANG D, WEI Y, PAGLIASSOTTI MJ.Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis[J].Endocrinology, 2006, 147 (2) :943-951.
|
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