Schistosomiasis is a dangerous infectious disease,and advanced schistosomiasis is a serious harm to people' s lives and health.Anthelmintic treatment alone cannot effectively prevent the development and progression of advanced schistosomiasis,especially liver fibrosis.This article introduces the pathogenesis,clinical manifestations,and integrated traditional Chinese and Western medicine therapy for advanced schistosomiasis.It is pointed out that integrated traditional Chinese and Western medicine therapy is an effective approach to the control of disease progression in patients with liver fibrosis.