Interventional therapy has become the first choice of non-surgical treatment for hepatocellular carcinoma(HCC) due to its advantages such as little trauma and marked local effect.However,the clinical efficiency is less than expected.One of the possibilities is the resistance of cancer cells to anti-cancer drugs.Increasing attention has been paid to the combination of traditional Chinese medicine(TCM) and interventional therapy in HCC treatment.This paper reviews the progress in TCM combined with interventional therapy for HCC at animal experiment and clinical study levels in recent ten years.It is pointed out that the combination therapy with TCM and intervention for HCC has a unique advantage.